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there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function
In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport.
Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2.
Decreased placental mTOR (show FRAP1 ELISA Kits) activity causes down-regulation of placental system A activity by shifting SNAT-2 trafficking towards proteasomal degradation, thereby contributing to decreased fetal amino acid availability and restricted fetal growth in IUGR.
GADD34 (show PPP1R15A ELISA Kits) promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter (show SLC43A2 ELISA Kits) SNAT2.
Increased availability of unsaturated fatty acids can compromise the stress-induced induction/adaptation in SNAT2 expression.
SLC38A1 (show SLC38A1 ELISA Kits) and SLC38A2 transcript levels are altered in placental malaria with intervillositis.
SNAT2 mRNA levels were significantly decreased in intrauterine growth-restricted placentas with reduced umbilical blood flows.
Placental mRNA expression of system A transporter isoforms SLC38A1 (show SLC38A1 ELISA Kits) and -2 was lower in teenagers than in adults which may underlie their susceptibility to delivering small-for-gestational-age infants.
findings show methylation status of rRNA differentially influenced the mechanism of 80S complex formation on IRES elements from SNAT2)versus the hepatitis C virus mRNA
GADD34 (show PPP1R15A ELISA Kits) promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter (show SLC38A7 ELISA Kits) ATA2.
These data reveal an unexpected role for amino acid uptake and the amino acid transporter (show SLC38A7 ELISA Kits) SNAT2 in regulation of pluripotent cells in culture.
The inward current of Na(+) associated with the function of SNAT2 leads to membrane depolarization and activation of voltage-sensitive Ca(2 (show CA2 ELISA Kits)+) channels that mediate Ca(2 (show CA2 ELISA Kits)+) influx, thereby leading to an increase in the [Ca(2 (show CA2 ELISA Kits)+)](i) in enteroendocrine cells.
Insulin (show INS ELISA Kits) promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter (show SLC38A7 ELISA Kits) from an endosomal compartment in skeletal muscle cells. (ATA2 or SAT2 (show SAT2 ELISA Kits))
crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4 (show SLC38A4 ELISA Kits), Slc38a2, and Slc2a3 (show SLC2A3 ELISA Kits)) may be a component of the genetic control of nutrient supply and demand during mammalian development
ATA2 on the plasma membrane is subject to polyubiquitination by Nedd4-2 with consequent endocytotic sequestration and proteasomal degradation
the insulin (show INS ELISA Kits)-stimulated translocation pathways for ATA2 and GLUT4 (show SLC2A4 ELISA Kits) in adipocytes are distinct, involving different storage sites
SNAT2 not only regulates mTOR (show FRAP1 ELISA Kits) but also regulates proteolysis through PI3K and provides a link among acidosis, insulin (show INS ELISA Kits) resistance, and protein wasting in skeletal muscle cells.
Despite increased ATF4 (show ATF4 ELISA Kits) binding at the C/EBP (show CEBPA ELISA Kits)-ATF composite site following activation of the unfolded protein response, system A transporter 2 (show SLC38A1 ELISA Kits) (SNAT2) transcription activity is repressed
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1 (By similarity).
solute carrier family 38, member 2
, Amino acid transporter A2
, sodium-coupled neutral amino acid transporter 2
, sodium-coupled neutral amino acid transporter 2-like
, amino acid transporter A2
, system A amino acid transporter 2
, system A transporter 1
, system N amino acid transporter 2
, amino acid transporter 2
, protein 40-9-1
, solute carrier family 38 member 2
, amino acid system A transporter
, amino acid transporter cationic 2
, amino acid transporter system A2
, amino acid transporter, cationic 2 (low affinity)
, Sodium-coupled neutral amino acid transporter 2
, Solute carrier family 38 member 2
, System A amino acid transporter 2
, System A transporter 1
, System N amino acid transporter 2