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Browse our AlkB, Alkylation Repair Homolog 1 (E. Coli) Proteins (ALKBH)

Full name:
AlkB, Alkylation Repair Homolog 1 (E. Coli) Proteins (ALKBH)
On www.antibodies-online.com are 5 AlkB, Alkylation Repair Homolog 1 (E. Coli) (ALKBH) Proteins from 4 different suppliers available. Additionally we are shipping AlkB, Alkylation Repair Homolog 1 (E. Coli) Antibodies (45) and AlkB, Alkylation Repair Homolog 1 (E. Coli) Kits (1) and many more products for this protein. A total of 56 AlkB, Alkylation Repair Homolog 1 (E. Coli) products are currently listed.
Synonyms:
2700073G19Rik, Abh, ABH1, alkB, ALKBH, hABH
list all proteins Gene Name GeneID UniProt
Rat ALKBH ALKBH 362766  
ALKBH 8846 Q13686
ALKBH 211064 P0CB42

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AlkB, Alkylation Repair Homolog 1 (E. Coli) Proteins (ALKBH) by Origin

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Human AlkB, Alkylation Repair Homolog 1 (E. Coli) (ALKBH) interaction partners

  1. AlkB has a wide variety of substrates, including monoalkyl and exocyclic bridged adducts. (Review)

  2. ALKBH1's role in class switch recombination and abasic site cleavage during base excision repair

  3. Primary and secondary lysine residues of ALKBH1 are involved in lyase reactions and form a covalent adduct with the 5'DNA product, demonstrating two plausible chemical mechanisms to account for the covalent attachment.

  4. Homology modeling and different tertiary structure based study were performed on human AlkB homolog hABH1.

  5. show that ABH1 unexpectedly has a second activity, cleaving DNA at abasic (AP) sites such as those arising spontaneously from alkylation-dependent depurination reactions.

  6. AlkB homologues, hABH2 and hABH3, also are oxidative DNA demethylases; AlkB and hABH3, but not hABH2, also repair RNA

  7. hABH1 is a functional mitochondrial AlkB homolog that repairs 3-methylcytosine in single-stranded DNA and RNA.

Mouse (Murine) AlkB, Alkylation Repair Homolog 1 (E. Coli) (ALKBH) interaction partners

  1. ALKBH1's role in class switch recombination and abasic site cleavage during base excision repair

  2. Results suggest that ALKBH1 is involved in neural development by modifying the methylation status of histone H2A.

  3. The study reports a remarkable >1000-fold upregulation of individual piRNAs in pachytene spermatocytes isolated from Alkbh1-deficient murine testes.

  4. Data suggest that Alkbh1 mediates gene regulation in spermatogenesis, and that Alkbh1 is essential for normal sex-ratio distribution and embryonic development.

  5. Alkbh1 performs important functions in placental trophoblast lineage differentiation and participates in mechanisms of transcriptional regulation.

AlkB, Alkylation Repair Homolog 1 (E. Coli) (ALKBH) Protein Profile

Protein Summary

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine.

Alternative names and synonyms associated with AlkB, Alkylation Repair Homolog 1 (E. Coli) (ALKBH)

  • alkB, alkylation repair homolog 1 (E. coli) (Alkbh1)
  • alkB, alkylation repair homolog 1 (E. coli) (ALKBH1)
  • 2700073G19Rik protein
  • Abh protein
  • ABH1 protein
  • alkB protein
  • ALKBH protein
  • hABH protein

Protein level used designations for ALKBH

alkylated DNA repair protein alkB homolog 1 , DNA lyase ABH1 , DNA oxidative demethylase ALKBH1 , alkylation repair, alkB homolog , alpha-ketoglutarate-dependent dioxygenase ABH1

GENE ID SPECIES
362766 Rattus norvegicus
8846 Homo sapiens
211064 Mus musculus
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