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Human ALKBH3 Protein expressed in Escherichia coli (E. coli) - ABIN667398
Duncan, Trewick, Koivisto, Bates, Lindahl, Sedgwick: Reversal of DNA alkylation damage by two human dioxygenases. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Results show that PCA1 (show ENPP1 Proteins) expression was positively correlated with advanced stages in renal cell carcinoma (show MOK Proteins) and strongly suggest that PCA-1 (show ENPP1 Proteins) may be functionally important and a novel molecular target for human renal cell carcinoma (show MOK Proteins).
It was shown for first time that DNA glycosylase ALKBH3 can repair DNA adduct 3,N4-ethenocytosine from single-stranded DNA.
ALKBH3 contributes to development of urothelial carcinomas by accelerating their survival, angiogenesis, and invasion
ALKBH3 gene silencing markedly induces apoptosis in hormone-independent prostate cancer cell line DU145.
Our results establish PCA-1/ALKBH3 as important gene in pancreatic cancer
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
ALKBH3 contributes significantly to cancer cell survival and may be a therapeutic target for human adenocarcinoma of the lung.
This work has provided a detailed understanding of the structural features of the single-stranded DNA and double-stranded DNA preferences of ABH2 (show ALKBH2 Proteins) and ABH3.
Divergent sequences outside of the active site determine substrate specificities of ABH3.
Crystallographic study reveals beta-strand jelly-roll fold of hABH3 that coordinates a catalytically active iron center by a conserved His1 (show HTN1 Proteins)-X-Asp (show ASIP Proteins)/Glu (show DCTN1 Proteins)-X(n)-His2 (show HTN3 Proteins) motif [ABH3]
ALKBH2 (show ALKBH2 Proteins) and ALKBH3 provide cancer protection similar to that of the DNA glycosylase AAG (show C16orf35 Proteins) and display apparent epistasis with Aag (show C16orf35 Proteins)
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002
alkylated DNA repair protein alkB homolog 3
, alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
, prostate cancer antigen 1
, prostate cancer antigen-1
, AlkB homolog 3