Browse our BTB (POZ) Domain Containing 12 (BTBD12) ELISA Kits

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BTB (POZ) Domain Containing 12 ELISA Kits (BTBD12)
On are 0 BTB (POZ) Domain Containing 12 (BTBD12) ELISA Kits from different suppliers available. Additionally we are shipping BTB (POZ) Domain Containing 12 Antibodies (28) and and many more products for this protein. A total of 32 BTB (POZ) Domain Containing 12 products are currently listed.
AI256635, AI426760, BTBD12, D16Bwg1016e, FANCP, MUS312, RGD1566009
list all ELISA KIts Gene Name GeneID UniProt
Rat BTBD12 BTBD12 302953  
Human BTBD12 BTBD12 84464 Q8IY92
Mouse BTBD12 BTBD12 52864 Q6P1D7

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More ELISA Kits for BTB (POZ) Domain Containing 12 Interaction Partners

Human BTB (POZ) Domain Containing 12 (BTBD12) interaction partners

  1. Data suggest that dimeric GEN1 binds with high affinity/selectivity to Holliday junctions, introducing two symmetrical hydrolytic cleavages of phosphodiester backbone; at present, less is known about SLX1-SLX4-MUS81 (show MUS81 ELISA Kits)-EME1 (show EME1 ELISA Kits) resolving enzyme complex. (GEN1 = Holliday junction 5' flap (show ALOX5AP ELISA Kits) endonuclease; SLX = structure-specific endonuclease subunit; MUS81 (show MUS81 ELISA Kits) = MUS81 (show MUS81 ELISA Kits) endonuclease; EME1 (show EME1 ELISA Kits) = essential meiotic endonuclease 1) [REVIEW]

  2. These data also indicate that HIV-1 and HIV-2 Vpr activate the DNA damage response through an SLX4-independent mechanism that remains uncharacterized.

  3. The functioning of SLX4 is dependent on its dimerization via an oligomerization motif called the BTB domain.

  4. SLX4-SLX1 Protein-independent Down-regulation of MUS81 (show MUS81 ELISA Kits)-EME1 (show EME1 ELISA Kits) Protein by HIV-1 Viral Protein R (Vpr).

  5. Results identified homozygous mutations in FANCA (show FANCA ELISA Kits) and FANCP/SLX4 genes, both located on chromosome 16, were the affected recessive FA genes in three and one family respectively. Genotyping with short tandem repeat markers and SNP arrays revealed uniparental disomy of the entire mutation-carrying chromosome 16 in all four patients.

  6. SLX4 (FANCP) and XPF (show ERCC4 ELISA Kits) (FANCQ) proteins interact with each other and play a vital role in the Fanconi anemia (show PALB2 ELISA Kits) (FA) DNA repair pathway. Study has revealed that the global minor allele, SLX4(Y546C), is defective in this interaction.

  7. SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.

  8. Identification and characterization of MUS81 (show MUS81 ELISA Kits) point mutations that abolish interaction with the SLX4 scaffold protein (show HOMER1 ELISA Kits).

  9. Vpr recruits the SLX4 endonuclease complex and Vpr-induced inappropriate activation of this complex leads to cell cycle arrest at the G2 phase.

  10. FANCP has versatile functions in genome maintenance, its mutations result in Fanconi anemia (show PALB2 ELISA Kits). (Review)

Mouse (Murine) BTB (POZ) Domain Containing 12 (BTBD12) interaction partners

  1. Data shed light on SLX4 recruitment, and they point to the existence of currently unidentified ubiquitylated ligands and E3 ligases that are crucial for ICL repair.

  2. SLX4 is a tumor suppressor, which activates XPF (show ERCC4 ELISA Kits)-ERCC1 (show ERCC1 ELISA Kits) nuclease (show DCLRE1C ELISA Kits) specificity in DNA crosslink repair.

  3. Data indicate that SLX1 and MUS81 (show MUS81 ELISA Kits)-EME1 (show EME1 ELISA Kits) nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4.

  4. these data indicate that BTBD12 functions throughout gametogenesis to maintain genome stability, possibly by co-ordinating repair processes and/or by linking DNA repair events to the cell cycle via ATM (show ATM ELISA Kits)

  5. mouse Slx4, a regulator of structure-specific nucleases, disruption phenocopies Fanconi anemia (show PALB2 ELISA Kits)

BTB (POZ) Domain Containing 12 (BTBD12) Antigen Profile

Antigen Summary

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.

Alternative names and synonyms associated with BTB (POZ) Domain Containing 12 (BTBD12)

  • SLX4 structure-specific endonuclease subunit (Slx4) Elisa Kit
  • SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (SLX4) Elisa Kit
  • SLX4 structure-specific endonuclease subunit (SLX4) Elisa Kit
  • SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (Slx4) Elisa Kit
  • AI256635 Elisa Kit
  • AI426760 Elisa Kit
  • BTBD12 Elisa Kit
  • D16Bwg1016e Elisa Kit
  • FANCP Elisa Kit
  • MUS312 Elisa Kit
  • RGD1566009 Elisa Kit

Protein level used designations for BTBD12

BTB (POZ) domain containing 12 , SLX4 structure-specific endonuclease subunit homolog , structure-specific endonuclease subunit SLX4 , BTB/POZ domain-containing protein 12

302953 Rattus norvegicus
453866 Pan troglodytes
416665 Gallus gallus
512193 Bos taurus
84464 Homo sapiens
52864 Mus musculus
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