Browse our anti-DCLRE1C (DCLRE1C) Antibodies

On www.antibodies-online.com are 89 DNA Cross-Link Repair 1C (DCLRE1C) Antibodies from 17 different suppliers available. Additionally we are shipping DCLRE1C Proteins (5) and many more products for this protein. A total of 102 DCLRE1C products are currently listed.
Synonyms:
9930121L06Rik, A-SCID, AI661365, Art, artemis, DCLREC1C, hSNM1C, nuclease, RS-SCID, SCIDA, SNM1C, Snm1l
list all antibodies Gene Name GeneID UniProt
DCLRE1C 64421 Q96SD1
DCLRE1C 259171 Q5XIX3
DCLRE1C 227525 Q8K4J0

Most Popular Reactivities for anti-DCLRE1C (DCLRE1C) Antibodies

anti-Human DCLRE1C Antibodies:

anti-Rat (Rattus) DCLRE1C Antibodies:

anti-Mouse (Murine) DCLRE1C Antibodies:

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More Antibodies against DCLRE1C Interaction Partners

Human DNA Cross-Link Repair 1C (DCLRE1C) interaction partners

  1. Data suggest that stimulation of Artemis nuclease/DCLRE1C activity by XRCC4 (show XRCC4 Antibodies)-DNA ligase IV (show LIG4 Antibodies) hetero-complex and efficiency of blunt-end ligation are determined by structural configurations at the DNA ends. (XRCC4 (show XRCC4 Antibodies) = X-ray repair cross complementing 4)

  2. An N-terminal fragment comprising the catalytic domain can interact both with itself and with a C-terminal fragment. Amino acid exchanges N456A+S457A+E458Q in the C terminus of full-length SCIDA resulted in unmasking of the N terminus and in increased SCIDA activity in cellular V(D)J recombination assays.

  3. Data demonstrate that DCLRE1C mutations can cause a phenotype presenting as only antibody deficiency.

  4. DCLRE1C and NCF1 (show NCF1 Antibodies) mutations have been found by whole-genome sequencing to cause primary immunodeficiency in unrelated patients.

  5. the nature and location of mutations correlate with the clinical phenotype of severe combined immunodeficiency (show PRKDC Antibodies)

  6. uncovered a nuclease, Artemis, as a PTIP (show PAXIP1 Antibodies)-binding protein

  7. the 5'-exonuclease (show EXO1 Antibodies) is intrinsic to ARTEMIS, making it relevant to the role of ARTEMIS in nonhomologous DNA end joining

  8. DNA ligase IV (show LIG4 Antibodies) and Artemis act cooperatively to promote nonhomologous end-joining

  9. 2 siblings are described with combined immunodeficiency (CID (show CENPA Antibodies)) and immunodysregulation caused by compound heterozygous Artemis mutations.

  10. Artemis levels significantly influence radiation toxicity in human cells

Mouse (Murine) DNA Cross-Link Repair 1C (DCLRE1C) interaction partners

  1. ATM (show ATM Antibodies) phosphorylates DNA-PKcs (show PRKDC Antibodies) to recruit Artemis and promote end-processing.

  2. we present T(-)B(-)NK(+) severe combined immunodeficiency (SCID (show PRKDC Antibodies)) phenotype after spontaneously occurring modification of Artemis gene in mice.

  3. deficient mice have a phenotype similar to that of DNA-PKcs (show PRKDC Antibodies)-deficient mice-including severe combined immunodeficiency (show PRKDC Antibodies) associated with defects in opening and joining V(D)J coding hairpin ends and increased cellular ionizing radiation sensitivity (artemis)

  4. Data show that Artemis appears to be required for a subset of nonhomologous DNA end joining reactions that require end processing [Artemis].

  5. Artemis/p53 (show TP53 Antibodies)-deficient mouse tumors lacked der(12 (show SLC29A2 Antibodies))t(12;15) translocations and c-myc (show MYC Antibodies) amplification.

  6. V(D)J and DNA repair defects seen in this Artemis-deficient mouse model are direct evidence that defective Artemis is the pathologic mechanism for the immunodeficiency phenotype of SCID (show PRKDC Antibodies) in Athabascan-speaking Native Americans.

  7. DNA-PK has Artemis-independent functions in class switch recombination and normal development

  8. Since Art deficient mice represent a model for radiation-sensitive severe combined immunodeficiency (show PRKDC Antibodies), we suggest that these patients may be at risk for both lymphoid and non-lymphoid cancers.

  9. DNA-PKcs (show PRKDC Antibodies) and Artemis open AAV inverted terminal repeat (ITR (show GPR180 Antibodies)) hairpin loops in a tissue-dependent manner.

  10. both DNA-PKcs (show PRKDC Antibodies) and, unexpectedly, Artemis are necessary for joining a subset of activation-induced cytidine deaminase (show AICDA Antibodies) (AID)-dependent DNA double-strand breaks

DCLRE1C Antigen Profile

Antigen Summary

This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity\; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA).

Alternative names and synonyms associated with DCLRE1C

  • DNA cross-link repair 1C (DCLRE1C) antibody
  • DNA cross-link repair 1C (Dclre1c) antibody
  • DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) (Dclre1c) antibody
  • 9930121L06Rik antibody
  • A-SCID antibody
  • AI661365 antibody
  • Art antibody
  • artemis antibody
  • DCLREC1C antibody
  • hSNM1C antibody
  • nuclease antibody
  • RS-SCID antibody
  • SCIDA antibody
  • SNM1C antibody
  • Snm1l antibody

Protein level used designations for DCLRE1C

DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) , artemis protein , protein artemis , DNA cross-link repair 1C , protein artemis-like , DNA cross-link repair 1C protein , PSO2 homolog , SNM1 homolog C , SNM1-like protein , severe combined immunodeficiency, type a (Athabascan) , chSNM1C , Artemis protein , DNA cross-link repair 1A, PSO2 homolog , artemis , mArt

GENE ID SPECIES
697493 Macaca mulatta
100056337 Equus caballus
100085149 Ornithorhynchus anatinus
100469797 Ailuropoda melanoleuca
100579542 Nomascus leucogenys
64421 Homo sapiens
517886 Bos taurus
259171 Rattus norvegicus
487123 Canis lupus familiaris
430764 Gallus gallus
100173437 Pongo abelii
227525 Mus musculus
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