Browse our DCLRE1C (DCLRE1C) ELISA Kits

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DNA Cross-Link Repair 1C ELISA Kits (DCLRE1C)
On are 0 DNA Cross-Link Repair 1C (DCLRE1C) ELISA Kits from different suppliers available. Additionally we are shipping DCLRE1C Antibodies (89) and DCLRE1C Proteins (5) and many more products for this protein. A total of 102 DCLRE1C products are currently listed.
9930121L06Rik, A-SCID, AI661365, Art, artemis, DCLREC1C, hSNM1C, nuclease, RS-SCID, SCIDA, SNM1C, Snm1l
list all ELISA KIts Gene Name GeneID UniProt
Human DCLRE1C DCLRE1C 64421 Q96SD1
Mouse DCLRE1C DCLRE1C 227525 Q8K4J0

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More ELISA Kits for DCLRE1C Interaction Partners

Human DNA Cross-Link Repair 1C (DCLRE1C) interaction partners

  1. Data suggest that stimulation of Artemis nuclease/DCLRE1C activity by XRCC4 (show XRCC4 ELISA Kits)-DNA ligase IV (show LIG4 ELISA Kits) hetero-complex and efficiency of blunt-end ligation are determined by structural configurations at the DNA ends. (XRCC4 (show XRCC4 ELISA Kits) = X-ray repair cross complementing 4)

  2. An N-terminal fragment comprising the catalytic domain can interact both with itself and with a C-terminal fragment. Amino acid exchanges N456A+S457A+E458Q in the C terminus of full-length SCIDA resulted in unmasking of the N terminus and in increased SCIDA activity in cellular V(D)J recombination assays.

  3. Data demonstrate that DCLRE1C mutations can cause a phenotype presenting as only antibody deficiency.

  4. DCLRE1C and NCF1 (show NCF1 ELISA Kits) mutations have been found by whole-genome sequencing to cause primary immunodeficiency in unrelated patients.

  5. the nature and location of mutations correlate with the clinical phenotype of severe combined immunodeficiency (show PRKDC ELISA Kits)

  6. uncovered a nuclease, Artemis, as a PTIP (show PAXIP1 ELISA Kits)-binding protein

  7. the 5'-exonuclease (show EXO1 ELISA Kits) is intrinsic to ARTEMIS, making it relevant to the role of ARTEMIS in nonhomologous DNA end joining

  8. DNA ligase IV (show LIG4 ELISA Kits) and Artemis act cooperatively to promote nonhomologous end-joining

  9. 2 siblings are described with combined immunodeficiency (CID (show CENPA ELISA Kits)) and immunodysregulation caused by compound heterozygous Artemis mutations.

  10. Artemis levels significantly influence radiation toxicity in human cells

Mouse (Murine) DNA Cross-Link Repair 1C (DCLRE1C) interaction partners

  1. ATM (show ATM ELISA Kits) phosphorylates DNA-PKcs (show PRKDC ELISA Kits) to recruit Artemis and promote end-processing.

  2. we present T(-)B(-)NK(+) severe combined immunodeficiency (SCID (show PRKDC ELISA Kits)) phenotype after spontaneously occurring modification of Artemis gene in mice.

  3. deficient mice have a phenotype similar to that of DNA-PKcs (show PRKDC ELISA Kits)-deficient mice-including severe combined immunodeficiency (show PRKDC ELISA Kits) associated with defects in opening and joining V(D)J coding hairpin ends and increased cellular ionizing radiation sensitivity (artemis)

  4. Data show that Artemis appears to be required for a subset of nonhomologous DNA end joining reactions that require end processing [Artemis].

  5. Artemis/p53 (show TP53 ELISA Kits)-deficient mouse tumors lacked der(12 (show SLC29A2 ELISA Kits))t(12;15) translocations and c-myc (show MYC ELISA Kits) amplification.

  6. V(D)J and DNA repair defects seen in this Artemis-deficient mouse model are direct evidence that defective Artemis is the pathologic mechanism for the immunodeficiency phenotype of SCID (show PRKDC ELISA Kits) in Athabascan-speaking Native Americans.

  7. DNA-PK has Artemis-independent functions in class switch recombination and normal development

  8. Since Art deficient mice represent a model for radiation-sensitive severe combined immunodeficiency (show PRKDC ELISA Kits), we suggest that these patients may be at risk for both lymphoid and non-lymphoid cancers.

  9. DNA-PKcs (show PRKDC ELISA Kits) and Artemis open AAV inverted terminal repeat (ITR (show GPR180 ELISA Kits)) hairpin loops in a tissue-dependent manner.

  10. both DNA-PKcs (show PRKDC ELISA Kits) and, unexpectedly, Artemis are necessary for joining a subset of activation-induced cytidine deaminase (show AICDA ELISA Kits) (AID)-dependent DNA double-strand breaks

DCLRE1C Antigen Profile

Antigen Summary

This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity\; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA).

Alternative names and synonyms associated with DCLRE1C

  • DNA cross-link repair 1C (DCLRE1C) Elisa Kit
  • DNA cross-link repair 1C (Dclre1c) Elisa Kit
  • DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) (Dclre1c) Elisa Kit
  • 9930121L06Rik Elisa Kit
  • A-SCID Elisa Kit
  • AI661365 Elisa Kit
  • Art Elisa Kit
  • artemis Elisa Kit
  • DCLREC1C Elisa Kit
  • hSNM1C Elisa Kit
  • nuclease Elisa Kit
  • RS-SCID Elisa Kit
  • SCIDA Elisa Kit
  • SNM1C Elisa Kit
  • Snm1l Elisa Kit

Protein level used designations for DCLRE1C

DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) , artemis protein , protein artemis , DNA cross-link repair 1C , protein artemis-like , DNA cross-link repair 1C protein , PSO2 homolog , SNM1 homolog C , SNM1-like protein , severe combined immunodeficiency, type a (Athabascan) , chSNM1C , Artemis protein , DNA cross-link repair 1A, PSO2 homolog , artemis , mArt

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100579542 Nomascus leucogenys
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430764 Gallus gallus
100173437 Pongo abelii
227525 Mus musculus
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