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Browse our Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) ELISA Kits

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Damage-Specific DNA Binding Protein 1, 127kDa ELISA Kits (DDB1)
On www.antibodies-online.com are 0 Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) ELISA Kits from different suppliers available. A total of 0 Damage-Specific DNA Binding Protein 1, 127kDa products are currently listed.
Synonyms:
127kDa, AA408517, ddb1, DDBA, p127-Ddb1, UV-DDB1, XAP1, XPCE, XPE, XPE-BF
list all ELISA KIts Gene Name GeneID UniProt
Mouse DDB1 DDB1 13194 Q3U1J4
Human DDB1 DDB1 1642 Q16531
Rat DDB1 DDB1 64470  

Show all synonyms

More ELISA Kits for Damage-Specific DNA Binding Protein 1, 127kDa Interaction Partners

Mouse (Murine) Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) interaction partners

  1. uncovered a novel biological role for CUL4A (show CUL4A ELISA Kits)-DDB1-CDT2 E3 ligase that regulates molecular circadian behaviors via promoting ubiquitination-dependent degradation of CRY1 (show CRY1 ELISA Kits)

  2. UCH-L1 disrupts a complex between the DDB1-CUL4 ubiquitin ligase complex.

  3. In a constructive process, pM27 recruits DDB1 to exploit ubiquitin ligase (show RNF123 ELISA Kits) complexes catalyzing the obstruction of the STAT2 (show STAT2 ELISA Kits)-dependent antiviral state of cells to permit viral replication.

  4. Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis.

  5. These results indicate that DDB1 plays an essential role in maintaining viability and genomic integrity of dividing cells.

  6. DDB1 plays an important role in development by controlling levels of cell cycle regulators and thereby maintaining genomic stability.

Human Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) interaction partners

  1. Our data are consistent with the idea that the CUL4A (show CUL4A ELISA Kits)/B-DDB1-CRBN (show CRBN ELISA Kits) complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (show CLCN1 ELISA Kits) channels.

  2. These results revealed a novel role of DDB in H3K56Ac deacetylation during early step of NER (show NR1H2 ELISA Kits) and the existence of active functional cross-talk between DDB-mediated damage recognition and H3K56Ac deacetylation.

  3. The identification of Vpr mutants which associate with DCAF1 but only poorly with DDB1 suggests that DCAF1 is necessary but is not sufficient for the Vpr association with DDB1-containing E3 ligase complex.

  4. Data support a model wherein DDB1 and DDB2 (show DDB2 ELISA Kits) cooperate to repress Bcl-2 (show BCL2 ELISA Kits) transcription. DDB2 (show DDB2 ELISA Kits) recognizes and binds to the Bcl-2 (show BCL2 ELISA Kits) P1 promoter, and HDAC1 (show HDAC1 ELISA Kits) is recruited through the DDB1 subunit associated with DDB2 (show DDB2 ELISA Kits) to deacetylate histone H3K9.

  5. The study presents the crystal structure of human CRBN (show CRBN ELISA Kits) bound to DDB1 and the drug lenalidomide.

  6. CUL4A (show CUL4A ELISA Kits)-DDB1-Rbx1 E3 ligase controls the quality of the PTS2 receptor (show PEX7 ELISA Kits) Pex7p.

  7. structures of the DDB1-CRBN (show CRBN ELISA Kits) complex bound to thalidomide, lenalidomide and pomalidomide

  8. In the three intrinsically IMiD-resistant cell lines that clearly express detectable levels of cereblon (show CRBN ELISA Kits), the absence of CRBN (show CRBN ELISA Kits) and DDB1 mutations suggest that potential cereblon (show CRBN ELISA Kits)-independent mechanisms of resistance exist

  9. UV-DDB examines sites on DNA in discrete steps before forming long-lived, nonmotile UV-DDB dimers (DDB1-DDB2 (show DDB2 ELISA Kits))2 at sites of damage.

  10. p73 (show TP73 ELISA Kits) interacts with the CDL4A complex by binding directly to DDB1. The CDL4A complex is able to monoubiquitylate p73 (show TP73 ELISA Kits), negatively affecting its transcriptional function.

Cow (Bovine) Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) interaction partners

  1. Bovine herpesvirus-1 VP8 interacts with DDB1 and is monoubiquitinated during infection.

Caenorhabditis elegans (C. elegans) Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) interaction partners

  1. Caenorhabditis elegans DDB-1 is required for the degradation of CDT-1 (show CDT1 ELISA Kits) during S phase. DDB-1 interacts specifically with CUL-4 but not with other C. elegans cullins.

  2. Data show that SKN-1 protein levels, nuclear accumulation, and activity are repressed by the WD40 repeat protein WDR-23, which interacts with the CUL-4/DDB-1 ubiquitin ligase to presumably target the transcription factor for proteasomal degradation.

Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) Antigen Profile

Antigen Summary

The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

Alternative names and synonyms associated with Damage-Specific DNA Binding Protein 1, 127kDa (DDB1)

  • damage-specific DNA binding protein 1, 127kDa (DDB1) Elisa Kit
  • damage-specific DNA binding protein 1, 127kDa (ddb1) Elisa Kit
  • DNA damage-binding protein 1-like (LOC100187356) Elisa Kit
  • damage specific DNA binding protein 1 (Ddb1) Elisa Kit
  • damage-specific DNA binding protein 1, 127kDa (Ddb1) Elisa Kit
  • Protein DDB-1 (ddb-1) Elisa Kit
  • 127kDa Elisa Kit
  • AA408517 Elisa Kit
  • ddb1 Elisa Kit
  • DDBA Elisa Kit
  • p127-Ddb1 Elisa Kit
  • UV-DDB1 Elisa Kit
  • XAP1 Elisa Kit
  • XPCE Elisa Kit
  • XPE Elisa Kit
  • XPE-BF Elisa Kit

Protein level used designations for DDB1

damage-specific DNA binding protein 1, 127kDa , DNA damage-binding protein 1-like , DDB p127 subunit , DNA damage-binding protein 1 , DNA repair protein , UV-damaged DNA-binding factor , damage-specific DNA-binding protein 1 , damage-specific DNA-binding protein, DNA repair , damaged-DNA recognition protein 1 , DNA damage-binding protein a , HBV X-associated protein 1 , UV-DDB 1 , UV-damaged DNA-binding protein 1 , XAP-1 , XPE-binding factor , xeroderma pigmentosum group E-complementing protein , damage specific DNA binding protein 1

GENE ID SPECIES
100059606 Equus caballus
451234 Pan troglodytes
100135265 Xenopus (Silurana) tropicalis
100187356 Ciona intestinalis
100354475 Oryctolagus cuniculus
100468274 Ailuropoda melanoleuca
13194 Mus musculus
1642 Homo sapiens
476067 Canis lupus familiaris
511951 Bos taurus
64470 Rattus norvegicus
374050 Gallus gallus
100173610 Pongo abelii
178156 Caenorhabditis elegans
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