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Browse our DDB2 (DDB2) ELISA Kits

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Damage-Specific DNA Binding Protein 2, 48kDa ELISA Kits (DDB2)
On are 5 Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) ELISA Kits from 2 different suppliers available. Additionally we are shipping DDB2 Antibodies (42) and DDB2 Proteins (9) and many more products for this protein. A total of 59 DDB2 products are currently listed.
2610043A19Rik, DDBB, si:dkey-45f10.3, UV-DDB2
list all ELISA KIts Gene Name GeneID UniProt
DDB2 107986 Q99J79
Rat DDB2 DDB2 100362121  
DDB2 1643 Q92466

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More ELISA Kits for DDB2 Interaction Partners

Mouse (Murine) Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) interaction partners

  1. Results indicate a transcriptional regulatory pathway of DDB2 that is directly linked to the mechanisms that suppress metastasis of colon cancer.

  2. Data indicate that poly(ADP-ribose) polymerase-1 (PARP-1 (show PARP1 ELISA Kits))collaborates with DNA-binding protein (show HSF4 ELISA Kits) 2 (DDB2) to increase the efficiency of the lesion recognition step of global genomic subpathway of NER (show NR1H2 ELISA Kits) (GG-NER (show NR1H2 ELISA Kits)).

  3. the anti-proliferative and the pro-senescence pathways of DDB2 and p21 are critical protection mechanisms against skin malignancies.

  4. Results show that, upon oxidative stress, DDB2 functions in a positive feedback loop by repressing the antioxidant genes to cause persistent accumulation of ROS (show ROS1 ELISA Kits) and induce premature senescence.

  5. These results demonstrate direct activation of the human DDB2 gene by p53 (show TP53 ELISA Kits). The corresponding region in the mouse DDB2 gene shared significant sequence identity with the human gene but was deficient for p53 (show TP53 ELISA Kits) binding and transcriptional activation.

  6. results demonstrate that DDB2 is well conserved between humans and mice and functions as a tumor suppressor, at least in part, by controlling p53 (show TP53 ELISA Kits)-mediated apoptosis after UV-irradiation

  7. DDB2-deficient mice developed spontaneous malignant tumors at a high rate between the ages of 20 and 25 months.

  8. DDB2 is involved in global repair in mouse epithelial cells.

  9. Ddb2 heterozygosity can facilitate tumor development as a haploinsufficient tumor suppressor

  10. results indicate the bulk of DDB2 interacts with lesions independent of XPC (show XPC ELISA Kits) & there is little interaction between the two recognition proteins on damaged DNA; propose a scenario in which DDB2 prepares UV-damaged chromatin for assembly of the NER (show NR1H2 ELISA Kits) complex

Human Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) interaction partners

  1. the release of NER (show NR1H2 ELISA Kits) components such as DNA damage binding protein 2 (DDB2) and Xeroderma Pigmentosum complementation group C (show XPC ELISA Kits) protein (XPC (show XPC ELISA Kits)) following oxidative stress might putatively involve their apoptotic role rather than DNA repair function.

  2. PKM2 interacts with DDB2 and reduces cell survival upon UV irradiation.

  3. DDB2 can bind to the promoter region of NEDD4L and recruit enhancer of zeste homolog 2 histone methyltransferase to repress NEDD4L transcription by enhancing histone H3 lysine 27 trimethylation at the NEDD4L promoter.

  4. data demonstrated that the DDB2 IRES activity was promoted during stress conditions. These results reveal a novel mechanism contributing to DDB2 expression

  5. DDB2 is involved in ubiquitination and degradation of PAQR3 in gastric cancer cells.

  6. DDB2 rs747650 is involved in androgen metabolism, inflammation processes and scar formation in severe acne.

  7. DDB2 plays an instrumental role in DNA damage induced ROS (show ROS1 ELISA Kits) accumulation, ROS (show ROS1 ELISA Kits) induced premature senescence and inhibition of skin tumorigenesis.

  8. DDB2 is protected by XPC (show XPC ELISA Kits) from ubiquitination and degradation in a stochastic manner; thus XPC (show XPC ELISA Kits) allows DDB2 to initiate multiple rounds of repair events, thereby contributing to the persistence of cellular DNA repair capacity

  9. DDB2 protein expression is low in ovarian tumor cells.

  10. Data support a model wherein DDB1 (show DDB1 ELISA Kits) and DDB2 cooperate to repress Bcl-2 (show BCL2 ELISA Kits) transcription. DDB2 recognizes and binds to the Bcl-2 (show BCL2 ELISA Kits) P1 promoter, and HDAC1 (show HDAC1 ELISA Kits) is recruited through the DDB1 (show DDB1 ELISA Kits) subunit associated with DDB2 to deacetylate histone H3K9.

DDB2 Antigen Profile

Antigen Summary

This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.

Alternative names and synonyms associated with DDB2

  • damage-specific DNA binding protein 2, 48kDa (DDB2) Elisa Kit
  • damage-specific DNA binding protein 2, 48kDa (ddb2) Elisa Kit
  • damage specific DNA binding protein 2 (Ddb2) Elisa Kit
  • damage-specific DNA binding protein 2 (ddb2) Elisa Kit
  • 2610043A19Rik Elisa Kit
  • DDBB Elisa Kit
  • si:dkey-45f10.3 Elisa Kit
  • UV-DDB2 Elisa Kit

Protein level used designations for DDB2

damage-specific DNA binding protein 2 (48kD) , damage-specific DNA binding protein 2, 48kDa , DNA damage-binding protein 2 , Damage-specific DNA-binding protein 2 , DNA damage-binding protein 2-like , damage-specific DNA-binding protein 2 , DDB p48 subunit , UV-DDB 2 , UV-damaged DNA-binding protein 2 , xeroderma pigmentosum group E protein

100051180 Equus caballus
451165 Pan troglodytes
483626 Canis lupus familiaris
493565 Xenopus (Silurana) tropicalis
713813 Macaca mulatta
100352386 Oryctolagus cuniculus
100390419 Callithrix jacchus
100454099 Pongo abelii
100605065 Nomascus leucogenys
107986 Mus musculus
100362121 Rattus norvegicus
100004133 Danio rerio
1643 Homo sapiens
519357 Bos taurus
423185 Gallus gallus
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