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Study found that a Gen1 mutation alone did not affect DNA repair or meiotic recombination in mice; it caused synthetic lethality when combined with Eme1 mutations at an early embryonic stage. Also, combination of Gen1 and Eme1 mutations makes embryonic fibroblasts more sensitive to DNA damage & mice less capable of meiotic recombination. These results indicate that Gen1 and Eme1 are functionally redundant in mice.
indicate that SLX1 and MUS81-EME1 nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4.
Mus81 (show MUS81 Proteins)-Eme1- and Rad54 (show RAD54L Proteins)-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway
These findings link Eme1 with the replication-associated chromatin modifier functions of Np95 (show UHRF1 Proteins) in the cellular response to DNA damage.
While Mus81 (show MUS81 Proteins)-Eme1 shares several common features with members of the 5' flap (show ALOX5AP Proteins) nuclease (show DCLRE1C Proteins) family, the combined structural, biochemical, and biophysical analyses explain why Mus81 (show MUS81 Proteins)-Eme1 preferentially cleaves 3' flap (show ALOX5AP Proteins) DNA substrates with 5' nicked ends.
Data show that three structure-selective endonucleases, SLX1-SLX4, MUS81-EME1, and GEN1, define two pathways of Holliday junctions (HJs) resolution in HeLa cells.
Data show that Mus81 (show MUS81 Proteins)/Eme1-dependent DNA damage--rather than a global increase in replication-fork stalling--is the cause of incomplete replication in Chk1 (show CHEK1 Proteins)-deficient cells.
Results demonstrate a novel role of Wee1 (show WEE1 Proteins) in controlling Mus81 (show MUS81 Proteins)-Eme1 and DNA replication in human cells.
EME-1 deficiency affects cell cycle progression and promotes DNA rereplication.
Mus81 (show MUS81 Proteins)-Eme1 can ensure coordinate, bilateral cleavage of Holliday junction-like structures.
the crystal structure of the Mus81 (show MUS81 Proteins)-Eme1 complex
results demonstrate a link between branch migration activity of hRad54 (show RAD54L Proteins) and structure-specific endonuclease activity of hMus81-Eme1, suggesting that the Rad54 (show ATRX Proteins) and Mus81 (show MUS81 Proteins)-Eme1 proteins may cooperate in the processing of Holliday junction-like intermediates
Low Eme1 levels were more sensitive to the drug than tumors with high levels.
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.
essential meiotic endonuclease 1 homolog 1 (S. pombe)
, essential meiotic endonuclease 1 homolog 2
, probable crossover junction endonuclease EME2
, crossover junction endonuclease EME1
, MMS4 homolog
, SLX2 structure-specific endonuclease subunit homolog A
, essential meiotic endonuclease 1 homolog 1
, homolog of yeast EME1 endonuclease