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Browse our Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) Proteins (EME1)

Full name:
Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) Proteins (EME1)
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Synonyms:
6820428D13, EME1, fc30c07, MMS4L, SLX2A, wu:fc30c07
list all proteins Gene Name GeneID UniProt
Mouse EME1 EME1 268465 Q8BJW7
Human EME1 EME1 146956 Q96AY2
Rat EME1 EME1 287634  

Show all synonyms

More Proteins for Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) Interaction Partners

Mouse (Murine) Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1) interaction partners

  1. indicate that SLX1 and MUS81-EME1 nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4.

  2. Mus81 (show MUS81 Proteins)-Eme1- and Rad54 (show RAD54L Proteins)-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway

  3. These findings link Eme1 with the replication-associated chromatin modifier functions of Np95 (show UHRF1 Proteins) in the cellular response to DNA damage.

Human Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1) interaction partners

  1. While Mus81 (show MUS81 Proteins)-Eme1 shares several common features with members of the 5' flap (show ALOX5AP Proteins) nuclease (show DCLRE1C Proteins) family, the combined structural, biochemical, and biophysical analyses explain why Mus81 (show MUS81 Proteins)-Eme1 preferentially cleaves 3' flap (show ALOX5AP Proteins) DNA substrates with 5' nicked ends.

  2. Data show that three structure-selective endonucleases, SLX1-SLX4, MUS81-EME1, and GEN1, define two pathways of Holliday junctions (HJs) resolution in HeLa cells.

  3. Data show that Mus81 (show MUS81 Proteins)/Eme1-dependent DNA damage--rather than a global increase in replication-fork stalling--is the cause of incomplete replication in Chk1 (show CHEK1 Proteins)-deficient cells.

  4. Results demonstrate a novel role of Wee1 (show WEE1 Proteins) in controlling Mus81 (show MUS81 Proteins)-Eme1 and DNA replication in human cells.

  5. EME-1 deficiency affects cell cycle progression and promotes DNA rereplication.

  6. Mus81 (show MUS81 Proteins)-Eme1 can ensure coordinate, bilateral cleavage of Holliday junction-like structures.

  7. the crystal structure of the Mus81 (show MUS81 Proteins)-Eme1 complex

  8. results demonstrate a link between branch migration activity of hRad54 (show RAD54L Proteins) and structure-specific endonuclease activity of hMus81-Eme1, suggesting that the Rad54 (show ATRX Proteins) and Mus81 (show MUS81 Proteins)-Eme1 proteins may cooperate in the processing of Holliday junction-like intermediates

  9. Low Eme1 levels were more sensitive to the drug than tumors with high levels.

Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1) Protein Profile

Protein Summary

This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1)

  • essential meiotic endonuclease 1 homolog 1 (S. pombe) (EME1)
  • essential meiotic endonuclease 1 homolog 1 (S. pombe) (eme1)
  • essential meiotic structure-specific endonuclease subunit 2 (eme2)
  • essential meiotic endonuclease 1 homolog 1 (S. pombe) (Eme1)
  • essential meiotic structure-specific endonuclease 1 (EME1)
  • essential meiotic structure-specific endonuclease 1 (Eme1)
  • essential meiotic structure-specific endonuclease 1 (eme1)
  • 6820428D13 protein
  • EME1 protein
  • fc30c07 protein
  • MMS4L protein
  • SLX2A protein
  • wu:fc30c07 protein

Protein level used designations for EME1

essential meiotic endonuclease 1 homolog 1 (S. pombe) , essential meiotic endonuclease 1 homolog 2 , probable crossover junction endonuclease EME2 , crossover junction endonuclease EME1 , MMS4 homolog , SLX2 structure-specific endonuclease subunit homolog A , essential meiotic endonuclease 1 homolog 1 , hMMS4 , homolog of yeast EME1 endonuclease

GENE ID SPECIES
422104 Gallus gallus
558350 Danio rerio
702273 Macaca mulatta
747125 Pan troglodytes
780321 Xenopus (Silurana) tropicalis
100056366 Equus caballus
491079 Canis lupus familiaris
100125299 Bos taurus
268465 Mus musculus
146956 Homo sapiens
287634 Rattus norvegicus
100137639 Xenopus laevis
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