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ERCC1 and XPF (show ERCC4 ELISA Kits) protect short telomeres from homologous recombination.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b (show BUB1B ELISA Kits)(H/H) mice, which have a faulty mitotic checkpoint (show BUB3 ELISA Kits), and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand crosslink repair. we found that Bub1b (show BUB1B ELISA Kits)(H/H), but not Ercc1(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
these results establish USP45 as a new regulator of XPF (show ERCC4 ELISA Kits)-ERCC1 crucial for efficient DNA repair
ERCC1 is critical for protecting chondrocytes from catabolic stress and is associated with the pathophysiology of osteoarthritis.
SLX4 (show BTBD12 ELISA Kits) is a tumor suppressor, which activates XPF (show ERCC4 ELISA Kits)-ERCC1 nuclease (show DCLRE1C ELISA Kits) specificity in DNA crosslink repair.
ERCC1 is essential for melanoma growth and resistance to cisplatin.
Smad4 (show SMAD4 ELISA Kits) loss-associated Snail (show SNAI1 ELISA Kits) reduction compromises Ercc1-mediated DNA repair, contributing to increased UV-induced skin carcinogenesis.
analysis of accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(delta/-) mouse
This study demonistrated that the ERCC1 deficiency-associated downregulation of the cholesterol biosynthesis pathway is at least in part due to lowered expression of its master transcription factor SREBF2 (show SREBF2 ELISA Kits)
we have identified a novel skin-specific Ercc1 transcript in mice that originates from a promoter approximately 400 bp upstream of the normal promoter, rather than from more distant potential transcriptional start sites.
Ercc1(Delta/-) mice develop widespread astrocytosis and microgliosis, and motor neuron loss and denervation of skeletal muscle fibers.
ERCC1 expression was identified as a prognostic marker for overall survival in the patient cohort with operable lesions. Taken together, our data identify ERCC1 as a disease marker in lung adenoma patients from Xuanwei and confirm the significance of resection for the subsequent effect of platinum treatment in these patients
ERCC1 is expressed in a significant proportion of upper tract urothelial carcinoma and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy.
RRM1 (show RRM1 ELISA Kits) and ERCC1 expression levels did not show any relationship with overall survival.
ERCC1 and BRCA1 were overexpressed in A549/DDP (show TIMM8A ELISA Kits) compared with A549 (P<0.05). ERCC1 and BRCA1siRNA transfection can significantly reduce ERCC1 and BRCA1 mRNA and protein expression (P<0.05). Downregulating ERCC1 and BRCA1 expression obviously inhibited cell proliferation and increased caspase 3 (show CASP3 ELISA Kits) activity (P<0.05). Downregulating ERCC1 and BRCA1 significantly decreased PI3K (show PIK3CA ELISA Kits) and AKT (show AKT1 ELISA Kits) phosphorylation levels (P<0.05).
RRM1 (show RRM1 ELISA Kits) and ERCC wild type alleles are risk-reducing factor for Coronary artery disease (CAD (show CAD ELISA Kits)). Also, carrying RRM1 (show RRM1 ELISA Kits) A allele might have a protective effect for smokers.
The genetic polymorphisms of ERCC1-8092 are associated with the risk of hepatocellular carcinoma in Guangxi Zhuang population of China
Immunohistochemical expression of ERCC1 and XRCC1 (show XRCC1 ELISA Kits) has some predictive and prognostic values in patients with biliary tract cancer. Nuclear expression of ERCC1 and XRCC1 (show XRCC1 ELISA Kits) may be used to predict therapeutic response in patients undergoing gemcitabine monotherapy.
ERCC1 rs3212986 gene polymorphism has a significant effect on the pharmacokinetics and treatment outcome of gastric cancer. No association was found between ERCC1 rs11615 and overall survival of gastric cancer.
study finds that ERCC1 and RRM1 (show RRM1 ELISA Kits) are not independent prognostic factors of recurrence in stage I non-small cell lung cancer patients
High ERCC1 expression is associated with poor Response to Platinum-Based Induction Chemotherapy in Head and Neck Cancer.
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
DNA excision repair protein ERCC-1
, excision repair cross-complementing 1
, excision repair 1