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Browse our ERCC2 Proteins (ERCC2)

Full name:
Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 Proteins (ERCC2)
On www.antibodies-online.com are 4 Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) Proteins from 2 different suppliers available. Additionally we are shipping ERCC2 Antibodies (55) and many more products for this protein. A total of 64 ERCC2 products are currently listed.
Synonyms:
AA407812, AU020867, AW240756, CG9433, COFS2, CXPD, DhR3, DhXPD, Dmel\\CG9433, DmXPD, EM9, Ercc-2, ERCC2, l(2)SH2 2137, l(2)SH2137, MGC89573, TTD, xpd, XPD/ERCC2, zgc:56365
list all proteins Gene Name GeneID UniProt
Rat ERCC2 ERCC2 100361160  
ERCC2 2068 P18074
ERCC2 13871 O08811

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ERCC2 Proteins (ERCC2) by Origin

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Top referenced ERCC2 Proteins

  1. Human ERCC2 Protein expressed in Wheat germ - ABIN1353031 : Viau, Gastaldo, Bencokova, Joubert, Foray: Cadmium inhibits non-homologous end-joining and over-activates the MRE11-dependent repair pathway. in Mutation research 2008 (PubMed)

More Proteins for ERCC2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) interaction partners

  1. XPD expression significantly inhibited HepG2 cell proliferation, promoted HepG2 cell apoptosis, inhibited HepG2 colony formation, decreased HepG2 cells' migratory ability, and significantly lowered HepG2 cells' invasive capacity.

  2. A novel Crb-Galla-Xpd complex and its function for proper chromosome segregation.

  3. The multitask protein Xpd also plays an essential role in cell cycle regulation that appears to be independent of transcription or nucleotide excision repair.

  4. The variant genotypes of XPD Lys751Gln polymorphism are associated with a higher risk of esophageal adenocarcinoma.

Zebrafish Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) interaction partners

  1. the regulation and expression of XPD

  2. The zebrafish cDNA encoding xpd was isolated and examined its spatial-temporal expression during early development as well as its tissue distribution in adult zebrafish.

Human Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) interaction partners

  1. In conclusion, our study suggests that ERCC2 rs1799793 polymorphic variation could be used as a predictor for the prognosis of gastric cancer

  2. Data revealed the association of variant alleles of two polymorphisms, XRCC1 (show XRCC1 Proteins) rs25487 and ERCC2 rs1799793, with increased risk of breast cancer, providing evidence for their involvement in the etiology of breast cancer in ethnical Russians.

  3. Lys751Gln polymorphism of XPD gene can be used as one susceptibility factor for hepatocellular carcinoma

  4. study found that the ERCC2 Asn312Asp gene polymorphism likely plays an important role in influencing the chemotherapy response and overall survival of patients with osteosarcoma.

  5. The frequency of the XPD 312Asn allele was significantly higher in T >/= 2 high grade than in T >/= 2 low grade tumors (p = 0.036); the ERCC6 (show ERCC6 Proteins) 1097Val/Val genotype was strongly associated with muscle-invasive tumors.

  6. We aimed to conduct a meta-analysis to investigate the role of ERCC2 rs13181 on the risk of glioma

  7. There exists no obvious contribution of XPD genotypes to tumor size.

  8. XPD SNPs are not associated with acute coronary syndromes in patients from Pakistan.

  9. Structural insight into the mechanism of TFIIH (show GTF2H1 Proteins) recognition by the acidic string of the nucleotide excision repair factor XPC (show XPC Proteins) has been uncovered.

  10. It has been found that the genotype 751Gln/Gln and allele Gln of ERCC2 gene and allele Asp (show ASIP Proteins) of 312Asn/Asp (show ASIP Proteins) polymorphism of ERCC2 gene may be associated with an increased risk of colorectal cancer.

Mouse (Murine) Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) interaction partners

  1. Results describe a recessive cataract caused by a mutation in the Xpd/Ercc2 gene and demonstrate the importance of the gene not only for lens fiber cell differentiation, but also for the sensitivity to ionizing radiation.

  2. Compound TTD (show GTF2H5 Proteins)/XPCS heterozygosity partially rescues metabolic phenotype associated with homozygous XPD alleles. TTD (show GTF2H5 Proteins) allele dominates over XPCS allele in measures of UV-sensitivity.

  3. premature aging associated with XPD mutation in mice

  4. Mutations in XPD subunit of TFIIH (show GTF2H4 Proteins) result in transactivation defect of PPARs in the adipose tissue and the liver.

  5. New pathology features support the premature aging phenotype of Xpd(TTD) mutant mice and further strengthen the link between DNA damage, DNA repair and aging.

  6. XPCS with a G602D-encoding mutation in the Xpd helicase gene is the most skin cancer-prone NER (show NR1H2 Proteins) model to date, and it shows an unusual NER (show NR1H2 Proteins) dysfunction that is likely responsible for this susceptibility

  7. a variety of biallelic effects on organismal phenotype which attributes to combinations of recessive Xpd alleles

  8. results support a general model for premature aging in Xpd DNA repair deficient mice based on cellular responses to DNA damage that impair normal tissue homeostasis

  9. ERCC2 plays role in lung cancer development in a Chinese population.

ERCC2 Protein Profile

Protein Summary

The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with ERCC2

  • excision repair cross-complementing rodent repair deficiency, complementation group 2 (ERCC2)
  • Xeroderma pigmentosum D (Xpd)
  • excision repair cross-complementing rodent repair deficiency, complementation group 2 (ercc2)
  • excision repair cross-complementing rodent repair deficiency, complementation group 2 (LOC100361160)
  • excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2)
  • AA407812 protein
  • AU020867 protein
  • AW240756 protein
  • CG9433 protein
  • COFS2 protein
  • CXPD protein
  • DhR3 protein
  • DhXPD protein
  • Dmel\\CG9433 protein
  • DmXPD protein
  • EM9 protein
  • Ercc-2 protein
  • ERCC2 protein
  • l(2)SH2 2137 protein
  • l(2)SH2137 protein
  • MGC89573 protein
  • TTD protein
  • xpd protein
  • XPD/ERCC2 protein
  • zgc:56365 protein

Protein level used designations for ERCC2

DNA-repair protein complementing XP-D cells , excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D) , CG9433-PA , CG9433-PB , CG9433-PC , Xpd-PA , Xpd-PB , Xpd-PC , lethal (2) SH2137 , xeroderma pigmentosum D , TFIIH basal transcription factor complex helicase subunit , XPD , excision repair cross-complementing rodent repair deficiency, complementation group 2 protein , excision repair cross-complementing rodent repair deficiency, complementation group 2 , excision repair cross-complementing 2 , BTF2 p80 , CXPD , DNA excision repair protein ERCC-2 , DNA repair protein complementing XP-D cells , TFIIH 80 kDa subunit , TFIIH basal transcription factor complex 80 kDa subunit , TFIIH basal transcription factor complex helicase XPD subunit , TFIIH p80 , basic transcription factor 2 80 kDa subunit , xeroderma pigmentosum complementary group D , xeroderma pigmentosum group D-complementing protein , excision repair cross-complementing rodent repair deficiency, complementation group 6-like group 2

GENE ID SPECIES
100049685 Sus scrofa
37414 Drosophila melanogaster
393900 Danio rerio
456124 Pan troglodytes
493493 Xenopus (Silurana) tropicalis
493995 Canis lupus familiaris
100361160 Rattus norvegicus
2068 Homo sapiens
100125238 Bos taurus
13871 Mus musculus
308415 Rattus norvegicus
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