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These data support a model in which the interstrand crosslink repair-specific function of XPF-ERCC1 is dependent on recruitment, positioning and substrate recognition.
ERCC1 (show ERCC1 ELISA Kits) was not detectable in the nucleus of the XPF knockout cells indicating the necessity of a functional XPF/ERCC1 (show ERCC1 ELISA Kits) heterodimer to allow ERCC1 (show ERCC1 ELISA Kits) to enter the nucleus.
Strikingly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure. The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking reaction.
Based on structural models, NMR titrations, DNA-binding studies, site-directed mutagenesis, charge distribution, and sequence conservation, we propose that the HhH (show SLC25A15 ELISA Kits) domain of ERCC1 (show ERCC1 ELISA Kits) binds to dsDNA upstream of the damage, and XPF binds to the non-damaged strand within a repair bubble
silenced XPF significantly increased the sensitivity and survival following treatment with cisplatin in xenograft mice bearing renal cell tumor.
Polymorphisms in XPF gene is associated with gastrointestinal stromal tumours.
inherited abnormalities in DNA repair pathway related to XPF 30028C and TP53 (show TP53 ELISA Kits) Arg72Pro polymorphisms act as prognostic factors for progression free survival and overall survival of cutaneous melanoma patients.
Based on these results, we conclude that the XPF gene polymorphism Ser835Ser may be associated with a decreased risk of colorectal cancer.
Polymorphisms of ERCC4 gene are associated with HPV-positive cervical cancer.
Helicobacter Pylori introduces double-stranded DNA breaks by the nucleotide excision repair endonucleases XPF and XPG (show ERCC5 ELISA Kits), which, together with RelA (show NFkBP65 ELISA Kits), are recruited to chromatin in a highly coordinated, type IV secretion system-dependent manner.
SLX4 (FANCP (show BTBD12 ELISA Kits)) and XPF (FANCQ) proteins interact with each other and play a vital role in the Fanconi anemia (show PALB2 ELISA Kits) (FA) DNA repair pathway.
ERCC1 (show ERCC1 ELISA Kits)-XPF cooperates with CTCF (show CTCF ELISA Kits) and cohesin to facilitate the developmental silencing of imprinted genes and that persistent DNA damage triggers chromatin changes that affect gene expression programs associated with NER (show NR1H2 ELISA Kits) disorders.
these results establish USP45 as a new regulator of XPF-ERCC1 (show ERCC1 ELISA Kits) crucial for efficient DNA repair
SLX4 (show BTBD12 ELISA Kits) is a tumor suppressor, which activates XPF-ERCC1 (show ERCC1 ELISA Kits) nuclease (show DCLRE1C ELISA Kits) specificity in DNA crosslink repair.
Data reveal an unanticipated involvement of the ERCC1 (show ERCC1 ELISA Kits)/XPF NER (show NR1H2 ELISA Kits) endonuclease in the regulation of telomere integrity.
mitomycin C triggered sister chromatid exchanges in wild-type cells but chromatid fusions in Ercc1 (show ERCC1 ELISA Kits)(-/-) and Xpf mutant cells, indicating that in their absence, repair of double-strand breaks(DSBs)is prevented.
In mice with overexpressed TRF2 (show TERF2 ELISA Kits), telomere loss is mediated by Xpf.
These data support the conclusion that, as in yeast, ERCC1 (show ERCC1 ELISA Kits)-XPF facilitates double-strand breaks repair via an end-joining mechanism that is Ku86 (show XRCC5 ELISA Kits) independent.
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).
DNA repair endonuclease XPF
, excision repair cross-complementing rodent repair deficiency, complementation group 4
, DNA repair endonuclease XPF-like
, DNA excision repair protein ERCC-4
, DNA repair protein complementing XP-F cells
, excision-repair, complementing defective, in Chinese hamster
, xeroderma pigmentosum group F-complementing protein
, xeroderma pigmentosum, complementation group F
, DNA repair endonuclease subunit
, Ercc4 protein-like