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anti-Human Exonuclease 1 Antibodies:
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Human Polyclonal Exonuclease 1 Primary Antibody for IF, WB - ABIN389397
Tishkoff, Amin, Viars, Arden, Kolodner: Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination. in Cancer research 1998
Show all 4 references for ABIN389397
Human Polyclonal Exonuclease 1 Primary Antibody for EIA, WB - ABIN358056
Lee Bi, Nguyen, Barsky, Fernandes, Wilson: Molecular interactions of human Exo1 with DNA. in Nucleic acids research 2002
Show all 4 references for ABIN358056
Human Polyclonal Exonuclease 1 Primary Antibody for WB - ABIN374943
Kim, Roh, Yoon, Kim, Park: MLH3 and EXO1 alterations in familial colorectal cancer patients not fulfilling Amsterdam criteria. in Cancer genetics and cytogenetics 2007
has exonuclease properties that are similar to the human WRN protein
study concludes that Exo1 gene polymorphism Lys589Glu may be associated with an increased risk of colorectal cancer in the Polish population
Mutations within the EXO1 gene are not associated with premature ovarian failure in Han Chinese women.
EXO1 is more active on DNA at temperatures below 37 degrees C and this manifests as an increase in nuclease (show DCLRE1C Antibodies) activity.EXO1 preferentially cleaves one nucleotide inwards in a double stranded region of forked and nicked DNA flap (show ALOX5AP Antibodies) substrates.
CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent DNA repair resection.
MSH2 (show MSH2 Antibodies), MSH6 (show MSH6 Antibodies), and EXO1 genes were overexpressed in gastroesophageal cancers.
EXO1 and FEN1 (show FEN1 Antibodies) cleaved the substrate at the boundary between the single-stranded 5' flap (show ALOX5AP Antibodies) and the duplex, whereas FAN1 (show FSCN1 Antibodies) incised it three to four nucleotides in the double-stranded region.
In summary, phosphorylation of EXO1 by CDKs is a novel mechanism regulating repair pathway choice.
Our data present, for the first time, evidence that inherited MLH1 (show MLH1 Antibodies) c.-93G>A, MSH2 (show MSH2 Antibodies) c.211 + 9C>G, MSH3 (show MSH3 Antibodies) c.3133G>A, and EXO1 c.1765G>A abnormalities of DNA MMR (show MRC1 Antibodies) pathway are important determinants of head and neck squamous cell carcinoma
14-3-3 (show YWHAQ Antibodies) proteins restrain the Exo1 nuclease (show DCLRE1C Antibodies) to prevent over-resection in end joining
These studies establish that the Mlh1 (show MLH1 Antibodies)-Pms1 (show PMS1 Antibodies) endonuclease is required for MMR (show MRC1 Antibodies) in a previously uncharacterized Exo1-independent MMR (show MRC1 Antibodies) pathway.
The results establish a key role for EXO1 in modulating the severity of hypomorphic MRE11 (show MRE11A Antibodies) complex mutations.
Exo1-mediated HR is dispensable for stem cell function in quiescent HSC (show FUT1 Antibodies), whereas it is essential to HSC (show FUT1 Antibodies) response to DNA damage processing after cell cycle entry, and its loss is not compensated by intact NHEJ
In contrast to Exo1(null/null) mice, Exo1(E109K/E109K) knockin mice retain mismatch repair activity and display normal class switch recombination and meiosis.
RNAi-mediated EXO1 knockdown in mouse fibroblasts directly results in an alkylation-tolerant phenotype.
Exo1 contributes to the metabolism of DNA ends during DNA double-strand breaks repair in B lymphocytes.
Study documents the combinatorial action of Apollo (show DCLRE1B Antibodies), POT1b, CST (show CORT Antibodies), and the 5' exonuclease Exo1 in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.
EXO1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.
Apc (show APC Antibodies)(1638N) Exo1 Fen1 (show FEN1 Antibodies) mice survive longer (18 months)
EXO1 contributes to DNA damage signal induction in mammalian cells, and deletion of Exo1 can prolong survival in the context of telomere dysfunction.
Switch Junction Position Is Altered in Exo1-/- Mi
This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms.
, exonuclease I Exo1
, RNA exonuclease
, exonuclease 1
, rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
, exonuclease I
, exonuclease ExoI