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Browse our anti-LIG3 (LIG3) Antibodies

Full name:
anti-Ligase III, DNA, ATP-Dependent Antibodies (LIG3)
On www.antibodies-online.com are 68 Ligase III, DNA, ATP-Dependent (LIG3) Antibodies from 18 different suppliers available. Additionally we are shipping LIG3 Proteins (5) and LIG3 Kits (3) and many more products for this protein. A total of 80 LIG3 products are currently listed.
Synonyms:
An02g06890, AO090003000668, D11Wsu78e, DDBDRAFT_0218523, DDBDRAFT_0232266, DDB_0218523, DDB_0232266, LIG2, LIG3, orf36, wu:fb12c02, wu:fd10b03, wu:fm79b09
list all antibodies Gene Name GeneID UniProt
LIG3 3980 P49916
LIG3 303369  
LIG3 16882  

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Top referenced anti-LIG3 Antibodies

  1. Dog (Canine) Monoclonal LIG3 Primary Antibody for IF, WB - ABIN968692 : Chen, Tomkinson, Ramos, Mackey, Danehower, Walter, Schultz, Besterman, Husain: Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination. in Molecular and cellular biology 1995 (PubMed)
    Show all 4 references for ABIN968692

  2. Human Polyclonal LIG3 Primary Antibody for EIA, WB - ABIN951931 : Cotner-Gohara, Kim, Hammel, Tainer, Tomkinson, Ellenberger: Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states. in Biochemistry 2010 (PubMed)

  3. Mouse (Murine) Polyclonal LIG3 Primary Antibody for IHC, WB - ABIN3022649 : Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. in Cell cycle (Georgetown, Tex.) 2015 (PubMed)

More Antibodies against LIG3 Interaction Partners

Human Ligase III, DNA, ATP-Dependent (LIG3) interaction partners

  1. The g.29661G>A and g.29059C>T polymorphisms of LIG3 may play a role in the keratoconus and Fuchs endothelial corneal dystrophy pathogenesis and can be considered as markers in these diseases.

  2. A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 (show XRCC1 Antibodies) gene on binding interaction of XRCC1 (show XRCC1 Antibodies) protein with ligase III.

  3. In the context of tyrosine kinase (show TXK Antibodies)-activated leukemias, c-MYC (show MYC Antibodies) contributes to aberrant DNA repair through downstream targets LIG3 and PARP1 (show PARP1 Antibodies) up-regulation.

  4. there is an absolute requirement for fully functional DNA ligase III (LIG3), but not ligase IV (LIG4 (show LIG4 Antibodies)), to facilitate the escape from a telomere-driven crisis.

  5. Results show that overexpression of DNA ligase III in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress.

  6. data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM (show ATM Antibodies) in regulating DNA Lig3 stability and consequently mtDNA repair

  7. Human Mre11 (show MRE11A Antibodies)/human Rad50 (show RAD50 Antibodies)/Nbs1 (show NBN Antibodies) and DNA ligase IIIalpha/XRCC1 (show XRCC1 Antibodies) protein complexes act together in an alternative nonhomologous end joining pathway.

  8. Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy.

  9. results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1 (show XRCC1 Antibodies)

  10. The collective results support a "jackknife model" in which the ZnF loads ligase III onto nicked DNA and conformational changes deliver DNA into the active site.

Mouse (Murine) Ligase III, DNA, ATP-Dependent (LIG3) interaction partners

  1. Results show that overexpression of DNA ligase III in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress.

  2. data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM (show ATM Antibodies) in regulating DNA Lig3 stability and consequently mtDNA repair

  3. Lig3 has an essential role in mtDNA maintenance but is dispensable for the viability of cultured cells

  4. data reveal that the critical biological role of Lig3 is to maintain mtDNA integrity and not Xrcc1 (show XRCC1 Antibodies)-dependent DNA repair

  5. results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1 (show XRCC1 Antibodies)

  6. Early embryonic lethality is due to targeted inactivation of DNA ligase III.

LIG3 Antigen Profile

Antigen Summary

This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with LIG3

  • ligase III, DNA, ATP-dependent (lig3) antibody
  • ligase III, DNA, ATP-dependent (LIG3) antibody
  • DNA ligase III (orf36) antibody
  • DNA ligase 3 (ANI_1_2644024) antibody
  • DNA ligase 3 (AOR_1_1174154) antibody
  • DNA ligase III (Bm1_22840) antibody
  • BRCT domain-containing protein (lig3) antibody
  • ligase III, DNA, ATP-dependent (Lig3) antibody
  • An02g06890 antibody
  • AO090003000668 antibody
  • D11Wsu78e antibody
  • DDBDRAFT_0218523 antibody
  • DDBDRAFT_0232266 antibody
  • DDB_0218523 antibody
  • DDB_0232266 antibody
  • LIG2 antibody
  • LIG3 antibody
  • orf36 antibody
  • wu:fb12c02 antibody
  • wu:fd10b03 antibody
  • wu:fm79b09 antibody

Protein level used designations for LIG3

ligase III, DNA, ATP-dependent , DNA ligase 3 , DNA ligase (ATP) 3 , DNA ligase 3 isoform alpha , DNA ligase III , DNA ligase 3-like , ligase II, DNA, ATP-dependent , polydeoxyribonucleotide synthase [ATP] 3

GENE ID SPECIES
336509 Danio rerio
417530 Gallus gallus
454581 Pan troglodytes
491145 Canis lupus familiaris
514719 Bos taurus
549105 Xenopus (Silurana) tropicalis
715181 Macaca mulatta
955080 Heliothis zea virus 1
4979178 Aspergillus niger CBS 513.88
5991803 Aspergillus oryzae RIB40
6099475 Brugia malayi
8624245 Dictyostelium discoideum AX4
100071671 Equus caballus
100344941 Oryctolagus cuniculus
100405358 Callithrix jacchus
100455958 Pongo abelii
100464510 Ailuropoda melanoleuca
100634887 Amphimedon queenslandica
3980 Homo sapiens
303369 Rattus norvegicus
16882 Mus musculus
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