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anti-Rat (Rattus) LIG3 Antibodies:
anti-Human LIG3 Antibodies:
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Chicken Monoclonal LIG3 Primary Antibody for BP, ICC - ABIN445494
Leppard, Dong, Mackey, Tomkinson: Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair. in Molecular and cellular biology 2003
Show all 10 Pubmed References
Human Monoclonal LIG3 Primary Antibody for ICC, IF - ABIN151084
Klungland, Hoess, Gunz, Constantinou, Clarkson, Doetsch, Bolton, Wood, Lindahl: Base excision repair of oxidative DNA damage activated by XPG protein. in Molecular cell 1999
Show all 8 Pubmed References
Dog (Canine) Monoclonal LIG3 Primary Antibody for IF, WB - ABIN968692
Chen, Tomkinson, Ramos, Mackey, Danehower, Walter, Schultz, Besterman, Husain: Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination. in Molecular and cellular biology 1995
Show all 4 Pubmed References
Dog (Canine) Monoclonal LIG3 Primary Antibody for IF, WB - ABIN968693
Mackey, Niedergang, Murcia, Leppard, Au, Chen, de Murcia, Tomkinson: DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III. in The Journal of biological chemistry 1999
Show all 4 Pubmed References
Human Polyclonal LIG3 Primary Antibody for ICC, IF - ABIN4305495
Fan, Li, Small, Rassool: Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy. in Blood 2010
Show all 2 Pubmed References
Mouse (Murine) Polyclonal LIG3 Primary Antibody for IHC, WB - ABIN3022649
Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. in Cell cycle (Georgetown, Tex.) 2015
single-stranded break repair by human DNA ligase III isoforms reveal biochemical differences from DNA ligase I (show LIG1 Antibodies)
The g.29661G>A and g.29059C>T polymorphisms of LIG3 may play a role in the keratoconus and Fuchs endothelial corneal dystrophy pathogenesis and can be considered as markers in these diseases.
A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 (show XRCC1 Antibodies) gene on binding interaction of XRCC1 (show XRCC1 Antibodies) protein with ligase III.
In the context of tyrosine kinase (show TXK Antibodies)-activated leukemias, c-MYC (show MYC Antibodies) contributes to aberrant DNA repair through downstream targets LIG3 and PARP1 (show PARP1 Antibodies) up-regulation.
there is an absolute requirement for fully functional DNA ligase III (LIG3), but not ligase IV (LIG4 (show LIG4 Antibodies)), to facilitate the escape from a telomere-driven crisis.
Results show that overexpression of DNA ligase III in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress.
data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM (show ATM Antibodies) in regulating DNA Lig3 stability and consequently mtDNA repair
Human Mre11 (show MRE11A Antibodies)/human Rad50 (show RAD50 Antibodies)/Nbs1 (show NBN Antibodies) and DNA ligase IIIalpha/XRCC1 (show XRCC1 Antibodies) protein complexes act together in an alternative nonhomologous end joining pathway.
Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy.
results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1 (show XRCC1 Antibodies)
Telomere-internal double-strand breaks (DSBs) are also repaired by a PARP1- and Ligase3-dependent reaction, suggesting alternative non-homologous end-joining (alt-NHEJ), which relies on microhomology at DSBs.
Lig3 has an essential role in mtDNA maintenance but is dispensable for the viability of cultured cells
data reveal that the critical biological role of Lig3 is to maintain mtDNA integrity and not Xrcc1 (show XRCC1 Antibodies)-dependent DNA repair
Early embryonic lethality is due to targeted inactivation of DNA ligase III.
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
DNA ligase III
, ligase III, DNA, ATP-dependent
, DNA ligase (ATP) 3
, DNA ligase 3
, ligase II, DNA, ATP-dependent
, polydeoxyribonucleotide synthase [ATP] 3
, DNA ligase 3 isoform alpha
, DNA ligase 3-like
, DNA ligase III isoform alpha
, ligase III, DNA, ATP-dependent L homeolog