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Browse our LIG3 Proteins (LIG3)

Full name:
Ligase III, DNA, ATP-Dependent Proteins (LIG3)
On www.antibodies-online.com are 5 Ligase III, DNA, ATP-Dependent (LIG3) Proteins from 3 different suppliers available. Additionally we are shipping LIG3 Antibodies (68) and LIG3 Kits (3) and many more products for this protein. A total of 80 LIG3 products are currently listed.
Synonyms:
An02g06890, AO090003000668, D11Wsu78e, DDBDRAFT_0218523, DDBDRAFT_0232266, DDB_0218523, DDB_0232266, LIG2, LIG3, orf36, wu:fb12c02, wu:fd10b03, wu:fm79b09
list all proteins Gene Name GeneID UniProt
LIG3 3980 P49916
Rat LIG3 LIG3 303369  
LIG3 16882  

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LIG3 Proteins (LIG3) by Origin

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Human Ligase III, DNA, ATP-Dependent (LIG3) interaction partners

  1. The g.29661G>A and g.29059C>T polymorphisms of LIG3 may play a role in the keratoconus and Fuchs endothelial corneal dystrophy pathogenesis and can be considered as markers in these diseases.

  2. A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 (show XRCC1 Proteins) gene on binding interaction of XRCC1 (show XRCC1 Proteins) protein with ligase III.

  3. In the context of tyrosine kinase (show TXK Proteins)-activated leukemias, c-MYC (show MYC Proteins) contributes to aberrant DNA repair through downstream targets LIG3 and PARP1 (show PARP1 Proteins) up-regulation.

  4. there is an absolute requirement for fully functional DNA ligase III (LIG3), but not ligase IV (LIG4 (show LIG4 Proteins)), to facilitate the escape from a telomere-driven crisis.

  5. Results show that overexpression of DNA ligase III in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress.

  6. data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM (show ATM Proteins) in regulating DNA Lig3 stability and consequently mtDNA repair

  7. Human Mre11 (show MRE11A Proteins)/human Rad50 (show RAD50 Proteins)/Nbs1 (show NBN Proteins) and DNA ligase IIIalpha/XRCC1 (show XRCC1 Proteins) protein complexes act together in an alternative nonhomologous end joining pathway.

  8. Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy.

  9. results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1 (show XRCC1 Proteins)

  10. The collective results support a "jackknife model" in which the ZnF loads ligase III onto nicked DNA and conformational changes deliver DNA into the active site.

Mouse (Murine) Ligase III, DNA, ATP-Dependent (LIG3) interaction partners

  1. Results show that overexpression of DNA ligase III in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress.

  2. data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM (show ATM Proteins) in regulating DNA Lig3 stability and consequently mtDNA repair

  3. Lig3 has an essential role in mtDNA maintenance but is dispensable for the viability of cultured cells

  4. data reveal that the critical biological role of Lig3 is to maintain mtDNA integrity and not Xrcc1 (show XRCC1 Proteins)-dependent DNA repair

  5. results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1 (show XRCC1 Proteins)

  6. Early embryonic lethality is due to targeted inactivation of DNA ligase III.

LIG3 Protein Profile

Protein Summary

This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with LIG3

  • ligase III, DNA, ATP-dependent (lig3)
  • ligase III, DNA, ATP-dependent (LIG3)
  • DNA ligase III (orf36)
  • DNA ligase 3 (ANI_1_2644024)
  • DNA ligase 3 (AOR_1_1174154)
  • DNA ligase III (Bm1_22840)
  • BRCT domain-containing protein (lig3)
  • ligase III, DNA, ATP-dependent (Lig3)
  • An02g06890 protein
  • AO090003000668 protein
  • D11Wsu78e protein
  • DDBDRAFT_0218523 protein
  • DDBDRAFT_0232266 protein
  • DDB_0218523 protein
  • DDB_0232266 protein
  • LIG2 protein
  • LIG3 protein
  • orf36 protein
  • wu:fb12c02 protein
  • wu:fd10b03 protein
  • wu:fm79b09 protein

Protein level used designations for LIG3

ligase III, DNA, ATP-dependent , DNA ligase 3 , DNA ligase (ATP) 3 , DNA ligase 3 isoform alpha , DNA ligase III , DNA ligase 3-like , ligase II, DNA, ATP-dependent , polydeoxyribonucleotide synthase [ATP] 3

GENE ID SPECIES
336509 Danio rerio
417530 Gallus gallus
454581 Pan troglodytes
491145 Canis lupus familiaris
514719 Bos taurus
549105 Xenopus (Silurana) tropicalis
715181 Macaca mulatta
955080 Heliothis zea virus 1
4979178 Aspergillus niger CBS 513.88
5991803 Aspergillus oryzae RIB40
6099475 Brugia malayi
8624245 Dictyostelium discoideum AX4
100071671 Equus caballus
100344941 Oryctolagus cuniculus
100405358 Callithrix jacchus
100455958 Pongo abelii
100464510 Ailuropoda melanoleuca
100634887 Amphimedon queenslandica
3980 Homo sapiens
303369 Rattus norvegicus
16882 Mus musculus
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