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The g.29661G>A and g.29059C>T polymorphisms of LIG3 may play a role in the keratoconus and Fuchs endothelial corneal dystrophy pathogenesis and can be considered as markers in these diseases.
A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 (show XRCC1 Proteins) gene on binding interaction of XRCC1 (show XRCC1 Proteins) protein with ligase III.
In the context of tyrosine kinase (show TXK Proteins)-activated leukemias, c-MYC (show MYC Proteins) contributes to aberrant DNA repair through downstream targets LIG3 and PARP1 (show PARP1 Proteins) up-regulation.
there is an absolute requirement for fully functional DNA ligase III (LIG3), but not ligase IV (LIG4 (show LIG4 Proteins)), to facilitate the escape from a telomere-driven crisis.
Results show that overexpression of DNA ligase III in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress.
data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM (show ATM Proteins) in regulating DNA Lig3 stability and consequently mtDNA repair
Human Mre11 (show MRE11A Proteins)/human Rad50 (show RAD50 Proteins)/Nbs1 (show NBN Proteins) and DNA ligase IIIalpha/XRCC1 (show XRCC1 Proteins) protein complexes act together in an alternative nonhomologous end joining pathway.
Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy.
results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1 (show XRCC1 Proteins)
The collective results support a "jackknife model" in which the ZnF loads ligase III onto nicked DNA and conformational changes deliver DNA into the active site.
Lig3 has an essential role in mtDNA maintenance but is dispensable for the viability of cultured cells
data reveal that the critical biological role of Lig3 is to maintain mtDNA integrity and not Xrcc1 (show XRCC1 Proteins)-dependent DNA repair
Early embryonic lethality is due to targeted inactivation of DNA ligase III.
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ligase III, DNA, ATP-dependent
, DNA ligase 3
, DNA ligase (ATP) 3
, DNA ligase 3 isoform alpha
, DNA ligase III
, DNA ligase 3-like
, ligase II, DNA, ATP-dependent
, polydeoxyribonucleotide synthase [ATP] 3