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Minichromosome Maintenance Complex Component 2 ELISA Kits (MCM2)
On www.antibodies-online.com are 14 Minichromosome Maintenance Complex Component 2 (MCM2) ELISA Kits from 10 different suppliers available. Additionally we are shipping Minichromosome Maintenance Complex Component 2 Antibodies (264) and Minichromosome Maintenance Complex Component 2 Proteins (8) and many more products for this protein. A total of 295 Minichromosome Maintenance Complex Component 2 products are currently listed.
Synonyms:
AA959861, AW476101, BM28, cb737, CCNL1, cdc19, CDCL1, CG7538, chunp6905, D3S3194, dMCM2, Dmel\\CG7538, DmeMCM2, DmMcm2, l(3)rL074, McM2, MCM2-7, MCM2_DROME, MCM7, Mcmd2, MITOTIN, mKIAA0030, PCR3, XMcm2
list all ELISA KIts Gene Name GeneID UniProt
MCM2 4171 P49736
Rat MCM2 MCM2 312538  
MCM2 17216 P97310

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More ELISA Kits for Minichromosome Maintenance Complex Component 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. Data show the structure of the Cdc45/Mcm2-7/Psf1 (show GINS1 ELISA Kits) GINS (CMG (show CASK ELISA Kits)) helicase (show DNA2 ELISA Kits) in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.

Zebrafish Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. the foxn1 (show FOXN1 ELISA Kits)-mcm2 axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish

Human Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. these findings suggest that lnc-FTX may act as a tumor suppressor in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) through physically binding miR (show MLXIP ELISA Kits)-374a and MCM2. It may also be one of the reasons for HCC (show FAM126A ELISA Kits) gender disparity and may potentially contribute to HCC (show FAM126A ELISA Kits) treatment

  2. Data suggest that interaction of Mcm10 (show MCM10 ELISA Kits) with Mcm2-7 multimer requires Mcm10 (show MCM10 ELISA Kits) domain that contains amino acids 530-655, which overlaps with domain required for stable retention of Mcm10 (show MCM10 ELISA Kits) on chromatin; Mcm10 (show MCM10 ELISA Kits) conserved domain (amino acids 200-482) is essential for DNA replication; both conserved domain and Mcm2-7-binding domain are required for full activity of Mcm10 (show MCM10 ELISA Kits).

  3. MCM2-MCM6 (show MCM6 ELISA Kits) complex is required for CHK2 (show CHEK2 ELISA Kits) chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells.

  4. BD ProExtrade mark C assay containing MCM2 and TOP2A (show TOP2A ELISA Kits) antibodies showed strong specific nuclear staining that correlated with increased cervical dysplasia and lesion severity.

  5. these data suggest that positive MCM2 and negative TIP30 (show HTATIP2 ELISA Kits) expression are closely correlated with the clinical, pathological and biological parameters, in addition to poor prognosis in patients with gallbladder cancer.

  6. knockdown of MCM2 or MCM6 could significantly inhibit foci forming of MDC1 in TE-1 nuclei in response to bleomycin-induced DNA damage (p < 0.001). This study indicates the direct interaction between MDC1 and MCMs in TE-1 nuclei.

  7. PTEN regulates DNA replication through MCM2 and loss of PTEN function leads to replication defects and genomic instability.

  8. MCM2 expression is higher in ovarian and endometrial high-grade serous carcinomas (HGSC) than in ovarian or endometrial endometrioid carcinoma. Knockdown in ovarian HGSC cell line decreased cell proliferation.

  9. quaternary complex of histone H3 (show HIST3H3 ELISA Kits)-H4 heterodimer with chaperone ASF1 (show SRSF1 ELISA Kits) and the replicative helicase subunit MCM2

  10. MCM2 is a novel gene responsible for nonsyndromic hearing loss of autosomal dominant inheritance in a Chinese family.

Xenopus laevis Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. Data show that MRE11 (show MRE11A ELISA Kits)- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG (show CASK ELISA Kits)) helicase (show DNA2 ELISA Kits) complex.

  2. Mcm2-7 associate with Cdc45 and GINS to form a relatively stable CMG (Cdc45-MCM-GINS) complex.

  3. ATM (show ATM ELISA Kits) and ATR (show ATR ELISA Kits) phosphorylate the functionally critical replication protein Mcm2 during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  4. MCM2-7 is the replicative helicase (show DNA2 ELISA Kits), dispensable for chromatin loading and pre-replicative complex (pre-RC) assembly, but required for origin unwinding during DNA replication

Mouse (Murine) Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. MCM2 is dynamically expressed in both proliferative and differentiated stromal cells during mouse periimplantation uterus. expression of Mcm2 is induced by progesterone action in the mouse uterine stroma. siRNA-mediated silencing of MCM2 arrests the cell cycle at G1-S transition during stromal cell proliferation. downregulation of Mcm2 could also compromise stromal cell differentiation.

  2. MCM2 deficiency reduces DNA replication initiation in gene-rich regions of the genome.

  3. these data demonstrate that active MCM2-7 repression is a physiologically important mechanism for RS-induced cell cycle arrest and genome maintenance on an organismal level.

  4. Hematopoietic cells originally express higher levels MCM 2 protein and undergo more frequent apoptosis following doxorubicin-induced DNA-damage in the presence of the FLV envelope protein gp70 (show EMB ELISA Kits).

  5. Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.

  6. Accumulation and dynamics of Mcm2 are described during oogenesis and the first embryonic cell cycle.

  7. gp70 (show EMB ELISA Kits) enhances cellular DNA-damage-induced signaling in association with host-specific cellular proteins including acinus (show ACIN1 ELISA Kits) and MCM2 resulting in the activation of DNA-PK to phosphorylate P53 (show TP53 ELISA Kits).

Minichromosome Maintenance Complex Component 2 (MCM2) Antigen Profile

Antigen Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.

Alternative names and synonyms associated with Minichromosome Maintenance Complex Component 2 (MCM2)

  • Minichromosome maintenance 2 (Mcm2) Elisa Kit
  • minichromosome maintenance complex component 2 (mcm2) Elisa Kit
  • MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) (mcm2) Elisa Kit
  • minichromosome maintenance complex component 2 (MCM2) Elisa Kit
  • minichromosome maintenance complex component 2 (Mcm2) Elisa Kit
  • minichromosome maintenance deficient 2 mitotin (S. cerevisiae) (Mcm2) Elisa Kit
  • AA959861 Elisa Kit
  • AW476101 Elisa Kit
  • BM28 Elisa Kit
  • cb737 Elisa Kit
  • CCNL1 Elisa Kit
  • cdc19 Elisa Kit
  • CDCL1 Elisa Kit
  • CG7538 Elisa Kit
  • chunp6905 Elisa Kit
  • D3S3194 Elisa Kit
  • dMCM2 Elisa Kit
  • Dmel\\CG7538 Elisa Kit
  • DmeMCM2 Elisa Kit
  • DmMcm2 Elisa Kit
  • l(3)rL074 Elisa Kit
  • McM2 Elisa Kit
  • MCM2-7 Elisa Kit
  • MCM2_DROME Elisa Kit
  • MCM7 Elisa Kit
  • Mcmd2 Elisa Kit
  • MITOTIN Elisa Kit
  • mKIAA0030 Elisa Kit
  • PCR3 Elisa Kit
  • XMcm2 Elisa Kit

Protein level used designations for MCM2

CG7538-PA , Mcm2-PA , minichromosome maintenance 2 , DNA replication licensing factor mcm2 , MCM2 minichromosome maintenance deficient 2, mitotin , minichromosome maintenance protein 2 , DNA replication licensing factor MCM2 , cell devision cycle-like 1 , cyclin-like 1 , minichromosome maintenance deficient 2 (mitotin) , minichromosome maintenance protein 2 homolog , nuclear protein BM28 , minichromosome maintenance deficient 2 mitotin , BM28-homolog , p112 , xMCM2 , minichromosome maintenance complex component 7 , mini chromosome maintenance deficient 2

GENE ID SPECIES
40973 Drosophila melanogaster
448458 Xenopus (Silurana) tropicalis
192338 Danio rerio
4171 Homo sapiens
312538 Rattus norvegicus
380451 Xenopus laevis
416027 Gallus gallus
484622 Canis lupus familiaris
510120 Bos taurus
17216 Mus musculus
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