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Browse our Minichromosome Maintenance Complex Component 2 Proteins (MCM2)

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Minichromosome Maintenance Complex Component 2 Proteins (MCM2)
On www.antibodies-online.com are 4 Minichromosome Maintenance Complex Component 2 (MCM2) Proteins from 3 different suppliers available. Additionally we are shipping Minichromosome Maintenance Complex Component 2 Antibodies (269) and Minichromosome Maintenance Complex Component 2 Kits (11) and many more products for this protein. A total of 293 Minichromosome Maintenance Complex Component 2 products are currently listed.
Synonyms:
AA959861, AW476101, BM28, cb737, CCNL1, cdc19, CDCL1, CG7538, chunp6905, D3S3194, dMCM2, Dmel\\CG7538, DmeMCM2, DmMcm2, l(3)rL074, McM2, MCM2-7, MCM2_DROME, MCM7, Mcmd2, MITOTIN, mKIAA0030, PCR3, XMcm2
list all proteins Gene Name GeneID UniProt
MCM2 4171 P49736
Rat MCM2 MCM2 312538  
MCM2 17216 P97310

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Minichromosome Maintenance Complex Component 2 Proteins (MCM2) by Origin

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Top referenced Minichromosome Maintenance Complex Component 2 Proteins

  1. Human MCM2 Protein expressed in Wheat germ - ABIN1310547 : Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011 (PubMed)

More Proteins for Minichromosome Maintenance Complex Component 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. Data show the structure of the Cdc45/Mcm2-7/Psf1 GINS (CMG) helicase in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.

Zebrafish Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. the foxn1 (show FOXN1 Proteins)-mcm2 axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish

Human Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. PTEN regulates DNA replication through MCM2 and loss of PTEN function leads to replication defects and genomic instability.

  2. MCM2 expression is higher in ovarian and endometrial high-grade serous carcinomas (HGSC) than in ovarian or endometrial endometrioid carcinoma. Knockdown in ovarian HGSC cell line decreased cell proliferation.

  3. quaternary complex of histone H3 (show HIST3H3 Proteins)-H4 heterodimer with chaperone ASF1 (show SRSF1 Proteins) and the replicative helicase subunit MCM2

  4. MCM2 is a novel gene responsible for nonsyndromic hearing loss of autosomal dominant inheritance in a Chinese family.

  5. The findings indicated that Mcm-2 could be a useful marker for early detection of oral squamous cell carcinoma

  6. MCM2 may be a novel therapeutic target of lovastatin treatment in NSCLCs.

  7. minichromosome maintenance protein-2 may serve as a useful marker in the screening of cervical carcinoma and precancerous lesions and improve the diagnosis of atypical squamous cell of undetermined significance

  8. Data indicate that minichromosome maintenance protein 2 (MCM2) binding is not required for incorporation of histone H3.1 (show HIST1H3A Proteins)-H4 into chromatin but is important for stability of H3.1-H4.

  9. The data suggest that MCM2 is not a good biomarker when comparing the different clinical stages of cervical cancer.

  10. Thermodynamic analysis of the quaternary complex together with structural modeling support that ASF1 (show SRSF1 Proteins) and MCM2 could form a chaperoning module for histones H3 and H4 protecting them from promiscuous interactions.

Xenopus laevis Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.

  2. Mcm2-7 associate with Cdc45 (show CDC45 Proteins) and GINS to form a relatively stable CMG (show CASK Proteins) (Cdc45 (show CDC45 Proteins)-MCM-GINS) complex.

  3. ATM (show ATM Proteins) and ATR phosphorylate the functionally critical replication protein Mcm2 during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  4. MCM2-7 is the replicative helicase, dispensable for chromatin loading and pre-replicative complex (pre-RC) assembly, but required for origin unwinding during DNA replication

Mouse (Murine) Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. MCM2 deficiency reduces DNA replication initiation in gene-rich regions of the genome.

  2. these data demonstrate that active MCM2-7 repression is a physiologically important mechanism for RS-induced cell cycle arrest and genome maintenance on an organismal level.

  3. Hematopoietic cells originally express higher levels MCM 2 protein and undergo more frequent apoptosis following doxorubicin-induced DNA-damage in the presence of the FLV envelope protein gp70 (show EMB Proteins).

  4. Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.

  5. Accumulation and dynamics of Mcm2 are described during oogenesis and the first embryonic cell cycle.

  6. gp70 (show EMB Proteins) enhances cellular DNA-damage-induced signaling in association with host-specific cellular proteins including acinus (show ACIN1 Proteins) and MCM2 resulting in the activation of DNA-PK to phosphorylate P53 (show TP53 Proteins).

Minichromosome Maintenance Complex Component 2 (MCM2) Protein Profile

Protein Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.

Alternative names and synonyms associated with Minichromosome Maintenance Complex Component 2 (MCM2)

  • Minichromosome maintenance 2 (Mcm2)
  • minichromosome maintenance complex component 2 (mcm2)
  • MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) (mcm2)
  • minichromosome maintenance complex component 2 (MCM2)
  • minichromosome maintenance complex component 2 (Mcm2)
  • minichromosome maintenance deficient 2 mitotin (S. cerevisiae) (Mcm2)
  • AA959861 protein
  • AW476101 protein
  • BM28 protein
  • cb737 protein
  • CCNL1 protein
  • cdc19 protein
  • CDCL1 protein
  • CG7538 protein
  • chunp6905 protein
  • D3S3194 protein
  • dMCM2 protein
  • Dmel\\CG7538 protein
  • DmeMCM2 protein
  • DmMcm2 protein
  • l(3)rL074 protein
  • McM2 protein
  • MCM2-7 protein
  • MCM2_DROME protein
  • MCM7 protein
  • Mcmd2 protein
  • MITOTIN protein
  • mKIAA0030 protein
  • PCR3 protein
  • XMcm2 protein

Protein level used designations for MCM2

CG7538-PA , Mcm2-PA , minichromosome maintenance 2 , DNA replication licensing factor mcm2 , MCM2 minichromosome maintenance deficient 2, mitotin , minichromosome maintenance protein 2 , DNA replication licensing factor MCM2 , cell devision cycle-like 1 , cyclin-like 1 , minichromosome maintenance deficient 2 (mitotin) , minichromosome maintenance protein 2 homolog , nuclear protein BM28 , minichromosome maintenance deficient 2 mitotin , BM28-homolog , p112 , xMCM2 , minichromosome maintenance complex component 7 , mini chromosome maintenance deficient 2

GENE ID SPECIES
40973 Drosophila melanogaster
448458 Xenopus (Silurana) tropicalis
192338 Danio rerio
4171 Homo sapiens
312538 Rattus norvegicus
380451 Xenopus laevis
416027 Gallus gallus
484622 Canis lupus familiaris
510120 Bos taurus
17216 Mus musculus
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