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Human Monoclonal MCM7 Primary Antibody for IF, IHC (p) - ABIN561764
Köhler, Kreuter, Rozynkowski, Rahmel, Uhl, Tannapfel, Schmidt, Meier: Validation of different replication markers for the detection of beta-cell proliferation in human pancreatic tissue. in Regulatory peptides 2010
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Human Polyclonal MCM7 Primary Antibody for ChIP, ICC - ABIN441356
Hubbi, Luo, Baek, Semenza: MCM proteins are negative regulators of hypoxia-inducible factor 1. in Molecular cell 2011
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Human Polyclonal MCM7 Primary Antibody for PLA, WB - ABIN151719
Nash, Chen, Muzyczka: Complete in vitro reconstitution of adeno-associated virus DNA replication requires the minichromosome maintenance complex proteins. in Journal of virology 2008
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Human Polyclonal MCM7 Primary Antibody for IP, WB - ABIN440771
Panneerselvam, Pickering, Han, Li, Zheng, Zhang, Zhang, Fei: Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate. in Oncotarget 2014
Human Polyclonal MCM7 Primary Antibody for IF, IP - ABIN2452047
Fujita, Kiyono, Hayashi, Ishibashi: hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase. in The Journal of biological chemistry 1996
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Human Monoclonal MCM7 Primary Antibody for FACS, IF - ABIN5583309
Koonin: A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication. in Nucleic acids research 1993
The MCM7 directly binds to the centrosomal linker protein (show LAT Antibodies) Cep68 in vitro and complexes with Cep68 and VHL (show VHL Antibodies) in vivo.
The results clearly demonstrate 7q21-22 amplification, MCM7, and its intronic miR (show MLXIP Antibodies)-25 are the major molecular switches involved in the complex oncogenic circuits of gastric cancer.
High MCM7 expression is associated with non-small cell lung cancer.
MCM4 (show MCM4 Antibodies) and MCM7 expression is significantly correlated with Ki-67 (show MKI67 Antibodies), Bmi1 (show BMI1 Antibodies), and cyclin E (show CCNE1 Antibodies) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.
Data suggest that interaction of Mcm10 (show MCM10 Antibodies) with Mcm2-7 (show MCM2 Antibodies) multimer requires Mcm10 (show MCM10 Antibodies) domain that contains amino acids 530-655, which overlaps with domain required for stable retention of Mcm10 (show MCM10 Antibodies) on chromatin; Mcm10 (show MCM10 Antibodies) conserved domain (amino acids 200-482) is essential for DNA replication; both conserved domain and Mcm2-7 (show MCM2 Antibodies)-binding domain are required for full activity of Mcm10 (show MCM10 Antibodies).
Results show that the expression of MCM7 gene and its microRNA, miR (show MLXIP Antibodies)-106b-25 cluster is reduced under hypoxia.
This MCM4 (show MCM4 Antibodies) mutation affected human MCM4 (show MCM4 Antibodies)/6/7 complex formation, since the complex containing the mutant MCM4 (show MCM4 Antibodies) protein is unstable and the mutant MCM4 (show MCM4 Antibodies) protein is tend to be degraded.
Authors found that MCM7 highly expressed in K562 cells rather than that in normal neutrophils. Thus, lentivirus-mediated shRNA targeting MCM7 was used to suppress its endogenous expression in K562 cells and develop a novel therapeutic strategy for leukemia.
MCM7 polymorphisms were associated with survival rate and prognosis in acute myeloid leukemia (show BCL11A Antibodies) patients.
The BCL2 (show BCL2 Antibodies), MCM7, and CCNE1 (show CCNE1 Antibodies) genes might play distinctive roles in cisplatin resistance in bladder cancer.
Mcm2-7 (show MCM2 Antibodies) associate with Cdc45 (show CDC45 Antibodies) and GINS to form a relatively stable CMG (show CASK Antibodies) (Cdc45 (show CDC45 Antibodies)-MCM-GINS) complex.
Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
cyclin D1 (show CCND1 Antibodies)/CDK4 (show CDK4 Antibodies) complexes play a direct role in altering an inhibitory RB.MCM7 complex possibly allowing for setting of the origin in preparation for DNA replication
MCM7 may be a highly informative biomarker for cervical cancer.
Substrate preference and helicase (show DNA2 Antibodies) actions of mouse MCM4 (show MCM4 Antibodies)/6/7 helicase (show DNA2 Antibodies) complexes.
Accumulation and dynamics of Mcm7 are described during oogenesis and the first embryonic cell cycle.
cellular DNA replication factor (show CDT1 Antibodies) MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by green tea catechins
DNA binding and helicase (show DNA2 Antibodies) activities of Mcm4 (show MCM4 Antibodies)/6/7 are significantly stimulated by Cdt1 (show CDT1 Antibodies)
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, minichromosome maintenance 7
, minichromosome maintenance-PCR1
, hypothetical protein
, minichromosome maintenance complex component 7
, minichromosome maintenance protein 2
, minichromosome maintenance protein 7
, minichromosome maintenance complex component 2
, DNA replication licensing factor MCM7-like
, DNA replication licensing factor MCM7
, CDC47 homolog
, homolog of S. cerevisiae Cdc47
, minichromosome maintenance deficient 7
, CDC47 homolog B
, DNA replication licensing factor mcm7-B
, minichromosome maintenance protein 7-B
, MCM7 minichromosome maintenance deficient 7
, mini chromosome maintenance deficient 7