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MCM7-cyclin D1 (show CCND1 ELISA Kits) pathway may participate in cancer progression.
The MCM7 directly binds to the centrosomal linker protein (show LAT ELISA Kits) Cep68 in vitro and complexes with Cep68 and VHL (show VHL ELISA Kits) in vivo.
The results clearly demonstrate 7q21-22 amplification, MCM7, and its intronic miR (show MLXIP ELISA Kits)-25 are the major molecular switches involved in the complex oncogenic circuits of gastric cancer.
High MCM7 expression is associated with non-small cell lung cancer.
MCM4 (show MCM4 ELISA Kits) and MCM7 expression is significantly correlated with Ki-67 (show MKI67 ELISA Kits), Bmi1 (show BMI1 ELISA Kits), and cyclin E (show CCNE1 ELISA Kits) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.
Data suggest that interaction of Mcm10 (show MCM10 ELISA Kits) with Mcm2-7 (show MCM2 ELISA Kits) multimer requires Mcm10 (show MCM10 ELISA Kits) domain that contains amino acids 530-655, which overlaps with domain required for stable retention of Mcm10 (show MCM10 ELISA Kits) on chromatin; Mcm10 (show MCM10 ELISA Kits) conserved domain (amino acids 200-482) is essential for DNA replication; both conserved domain and Mcm2-7 (show MCM2 ELISA Kits)-binding domain are required for full activity of Mcm10 (show MCM10 ELISA Kits).
Results show that the expression of MCM7 gene and its microRNA, miR (show MLXIP ELISA Kits)-106b-25 cluster is reduced under hypoxia.
This MCM4 (show MCM4 ELISA Kits) mutation affected human MCM4 (show MCM4 ELISA Kits)/6/7 complex formation, since the complex containing the mutant MCM4 (show MCM4 ELISA Kits) protein is unstable and the mutant MCM4 (show MCM4 ELISA Kits) protein is tend to be degraded.
Authors found that MCM7 highly expressed in K562 cells rather than that in normal neutrophils. Thus, lentivirus-mediated shRNA targeting MCM7 was used to suppress its endogenous expression in K562 cells and develop a novel therapeutic strategy for leukemia.
MCM7 polymorphisms were associated with survival rate and prognosis in acute myeloid leukemia (show BCL11A ELISA Kits) patients.
Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
cyclin D1 (show CCND1 ELISA Kits)/CDK4 (show CDK4 ELISA Kits) complexes play a direct role in altering an inhibitory RB.MCM7 complex possibly allowing for setting of the origin in preparation for DNA replication
MCM7 may be a highly informative biomarker for cervical cancer.
Substrate preference and helicase (show DNA2 ELISA Kits) actions of mouse MCM4 (show MCM4 ELISA Kits)/6/7 helicase (show DNA2 ELISA Kits) complexes.
Accumulation and dynamics of Mcm7 are described during oogenesis and the first embryonic cell cycle.
cellular DNA replication factor (show CDT1 ELISA Kits) MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by green tea catechins
DNA binding and helicase (show DNA2 ELISA Kits) activities of Mcm4 (show MCM4 ELISA Kits)/6/7 are significantly stimulated by Cdt1 (show CDT1 ELISA Kits)
Mcm2-7 associate with Cdc45 and GINS to form a relatively stable CMG (Cdc45-MCM-GINS) complex.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, DNA replication licensing factor MCM7
, homolog of S. cerevisiae Cdc47
, minichromosome maintenance deficient 7
, hypothetical protein
, minichromosome maintenance protein 7
, minichromosome maintenance complex component 7
, minichromosome maintenance protein 2
, MCM7 minichromosome maintenance deficient 7
, minichromosome maintenance complex component 2
, DNA replication licensing factor MCM7-like
, mini chromosome maintenance deficient 7
, CDC47 homolog B
, DNA replication licensing factor mcm7-B
, minichromosome maintenance protein 7-B
, minichromosome maintenance 7
, minichromosome maintenance-PCR1
, CDC47 homolog A
, DNA replication licensing factor mcm7-A
, minichromosome maintenance protein 7-A
, Minichromosome maintenance protein 7