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Browse our MGMT Proteins (MGMT)

Full name:
O6-Methylguanine-DNA-Methyltransferase Proteins (MGMT)
On www.antibodies-online.com are 27 O6-Methylguanine-DNA-Methyltransferase (MGMT) Proteins from 11 different suppliers available. Additionally we are shipping MGMT Antibodies (211) and MGMT Kits (28) and many more products for this protein. A total of 278 MGMT products are currently listed.
Synonyms:
Agat, AGT, AI267024
list all proteins Gene Name GeneID UniProt
MGMT 4255  
MGMT 17314 P26187
MGMT 25332 P24528

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MGMT Proteins (MGMT) by Origin

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Top referenced MGMT Proteins

  1. Human MGMT Protein expressed in Escherichia coli (E. coli) - ABIN666723 : Esteller, Gaidano, Goodman, Zagonel, Capello, Botto, Rossi, Gloghini, Vitolo, Carbone, Baylin, Herman: Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. in Journal of the National Cancer Institute 2002 (PubMed)
    Show all 2 references for ABIN666723

More Proteins for MGMT Interaction Partners

Human O6-Methylguanine-DNA-Methyltransferase (MGMT) interaction partners

  1. Eleven studies were included to evaluate the relationship between the status of MGMT promoter methylation and glioblastoma patients' survival. [meta-analysis]

  2. Experimental analysis showed that the edema/necrosis volume ratio, tumor/necrosis volume ratio, edema volume, and tumor location and enhancement characteristics were the most significant variables in respect to the status of MGMT promoter methylation in GBM

  3. Data show that patients with MGMT protein promoter methylation and isocitrate dehydrogenase 1 (IDH1 (show IDH1 Proteins)) somatic mutation had a better prognosis than those with MGMT methylation alone.

  4. Methylation was common in the laryngeal cancer specimens, but there was not a significant relationship between the methylation status of MGMT and clinicopathological parameters.

  5. Hypermethylation rate in MGMT gene promoter of cancer tissue was statistical higher than autologous controls which indicated that MGMT may play an important in the cancer development.

  6. MGMT promoter methylation is associated with pseudoprogression and predicts a longer median survival in GBM patients after TMZ-based chemoradiotherapy.

  7. The study confirmed the importance of the IDH1 (show IDH1 Proteins)/2 mutation and hypermethylation of the MGMT gene promoter being present in brain Glioma tissue.

  8. Results suggest that methylation at CpG islands of MGMT may be responsible for the downregulation of MGMT protein expression in gastrointestinal cancers.

  9. MGMT was an important in vitro predictor of temozolomide activity in colorectal cancer

  10. MGMT gene hypermethylation is associated with gliomas.

Mouse (Murine) O6-Methylguanine-DNA-Methyltransferase (MGMT) interaction partners

  1. This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG (show C16orf35 Proteins), as a key node in determining a carcinogenic threshold.

  2. Findings suggest that O6-methylguanine-DNA methyltransferase (MGMT)-mediated temozolomide resistance is associated with increased histone acetylation.

  3. Loss of MGMT expression and high Ezrin (show EZR Proteins) protein expression leads to esophageal cancer.

  4. Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.

  5. ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.

  6. Roles of MGMT and MLH1 (show MLH1 Proteins) proteins in alkylation-induced apoptosis and mutagenesis.

  7. Repression of MGMT is associated with precancerous conditions in hyperplastic mucosa adjacent to colon cancer

  8. GAMT (show GAMT Proteins) and AGAT (show GATM Proteins) mRNA are up-regulated 5.4- and 1.9-fold respectively in adult mdx (show DMD Proteins) muscle compared to C57

  9. MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

  10. Mgmt suppresses intestinal cancer associated with exogenous alkylating agents.

MGMT Protein Profile

Protein Summary

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a

Alternative names and synonyms associated with MGMT

  • O-6-methylguanine-DNA methyltransferase (MGMT)
  • O-6-methylguanine-DNA methyltransferase (Mgmt)
  • Agat protein
  • AGT protein
  • AI267024 protein

Protein level used designations for MGMT

6-O-methylguanine-DNA methyltransferase , O-6-methylguanine-DNA-alkyltransferase , O6-methylguanine-DNA methyltransferase , methylated-DNA--protein-cysteine methyltransferase , methylguanine-DNA methyltransferase , O-6-alkylguanine-DNA alkyltransferase , 0-6-methylguanine-DNA methyltransferase , O(6)-alkylguanine-DNA alkyltransferase , O6-alkylguanine-DNA alkyltransferase , O6-methylguanine-DNA methyltranferase , O6-alkylguanine-DNA-alkyltransferase , O6-methylguanine-DNA-methyltransferase

GENE ID SPECIES
4255 Homo sapiens
17314 Mus musculus
25332 Rattus norvegicus
100733185 Cavia porcellus
100155050 Sus scrofa
616091 Bos taurus
442978 Canis lupus familiaris
423965 Gallus gallus
101106897 Ovis aries
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