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Browse our MGMT Proteins (MGMT)

Full name:
O6-Methylguanine-DNA-Methyltransferase Proteins (MGMT)
On www.antibodies-online.com are 21 O6-Methylguanine-DNA-Methyltransferase (MGMT) Proteins from 9 different suppliers available. Additionally we are shipping MGMT Antibodies (178) and MGMT Kits (26) and many more products for this protein. A total of 237 MGMT products are currently listed.
Synonyms:
Agat, AGT, AI267024
list all proteins Gene Name GeneID UniProt
MGMT 4255  
MGMT 17314 P26187
MGMT 25332 P24528

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MGMT Proteins (MGMT) by Origin

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Top referenced MGMT Proteins

  1. Human MGMT Protein expressed in Escherichia coli (E. coli) - ABIN666723 : Esteller, Gaidano, Goodman, Zagonel, Capello, Botto, Rossi, Gloghini, Vitolo, Carbone, Baylin, Herman: Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. in Journal of the National Cancer Institute 2002 (PubMed)
    Show all 2 references for ABIN666723

More Proteins for MGMT Interaction Partners

Human O6-Methylguanine-DNA-Methyltransferase (MGMT) interaction partners

  1. MLH1 (show MLH1 Proteins) and MGMT methylation correlated inversely when the tumor was located in the lower third of the stomach

  2. SFN (show SFN Proteins) effectively inhibited activity of NF-kappaB (show NFKB1 Proteins) signaling pathway and then reduced MGMT expression.

  3. review the current role of MGMT methylation and other epigenetic alterations as potential treatment targets in GI tumors

  4. The combined use of IDH1 (show IDH1 Proteins) mutation and MGMT methylation status can be used as prognostic markers for long-term survival of patients with cerebral low-grade glioma.

  5. our studies prove a novel function of ERp29 (show ERP29 Proteins)\MGMT in cancer cell survival against radiation. Targeting ERp29 (show ERP29 Proteins)\MGMT axis may be useful for providing better treatment efficacy in combination with radiotherapy in breast cancer.

  6. Inhibition of DNA-repair genes Ercc1 (show ERCC1 Proteins) and Mgmt enhances temozolomide efficacy in glioma treatment.

  7. Five-miRNA signature is an independent risk predictor for GBM with MGMT promoter methylation and can be used to identify patients at high risk of unfavorable outcome and resistant to alkylating chemotherapy.

  8. the presence of only the A allele at the rs34180180 single nucleotide polymorphism in malignant glioma was significantly associated with shorter overall survival, independently of the MGMT methylation status

  9. BO-1055 can be used for treating tumors that with deficient NER (show NR1H2 Proteins), HR, and MGMT DNA repair genes.

  10. These data support the use of both MGMT methylation and MGMT IHC but not allelic methylation data as prognostic markers in patients with temozolomide-treated glioblastoma.

Mouse (Murine) O6-Methylguanine-DNA-Methyltransferase (MGMT) interaction partners

  1. This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG (show C16orf35 Proteins), as a key node in determining a carcinogenic threshold.

  2. Findings suggest that O6-methylguanine-DNA methyltransferase (MGMT)-mediated temozolomide resistance is associated with increased histone acetylation.

  3. Loss of MGMT expression and high Ezrin (show EZR Proteins) protein expression leads to esophageal cancer.

  4. Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.

  5. ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.

  6. Roles of MGMT and MLH1 (show MLH1 Proteins) proteins in alkylation-induced apoptosis and mutagenesis.

  7. Repression of MGMT is associated with precancerous conditions in hyperplastic mucosa adjacent to colon cancer

  8. GAMT (show GAMT Proteins) and AGAT (show GATM Proteins) mRNA are up-regulated 5.4- and 1.9-fold respectively in adult mdx (show DMD Proteins) muscle compared to C57

  9. MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

  10. Mgmt suppresses intestinal cancer associated with exogenous alkylating agents.

MGMT Protein Profile

Protein Summary

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a

Alternative names and synonyms associated with MGMT

  • O-6-methylguanine-DNA methyltransferase (MGMT)
  • O-6-methylguanine-DNA methyltransferase (Mgmt)
  • Agat protein
  • AGT protein
  • AI267024 protein

Protein level used designations for MGMT

6-O-methylguanine-DNA methyltransferase , O-6-methylguanine-DNA-alkyltransferase , O6-methylguanine-DNA methyltransferase , methylated-DNA--protein-cysteine methyltransferase , methylguanine-DNA methyltransferase , O-6-alkylguanine-DNA alkyltransferase , 0-6-methylguanine-DNA methyltransferase , O(6)-alkylguanine-DNA alkyltransferase , O6-alkylguanine-DNA alkyltransferase , O6-methylguanine-DNA methyltranferase , O6-alkylguanine-DNA-alkyltransferase , O6-methylguanine-DNA-methyltransferase

GENE ID SPECIES
4255 Homo sapiens
17314 Mus musculus
25332 Rattus norvegicus
100733185 Cavia porcellus
100155050 Sus scrofa
616091 Bos taurus
442978 Canis lupus familiaris
423965 Gallus gallus
101106897 Ovis aries
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