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the MGMT promoter homozygous rs1625649 (AA genotype) was found to correlate with a better PFS in patients with MGMT methylated glioblastoma
Using a large cohort of newly diagnosed adult gliomas with precise clinical information, study demonstrated that molecular classification using IDH (show IDH1 Proteins) and TERT (show TERT Proteins) statuses is a strong prognostic marker of adult gliomas. Results emphasize the importance of combining molecular markers such as IDH (show IDH1 Proteins), 1p/19q, TERT (show TERT Proteins), and MGMT for accurate molecular diagnosis, prognostication, and the choice of treatment.
Review/Meta-analysis: MGMT promoter methylation was associated with longer overall survival in glioblastoma patients.
Low MGMT expression is associated with pituitary adenoma tumor recurrence.
According to our results, albeit aberrant methylation of MGMT gene promoter can be observed in in vitro propagated Merkel cell carcinoma (MCC (show MCC Proteins))cell lines, it seems to be absent or very rare in MCC (show MCC Proteins) lesions in situ
Nitrogen mustard-induced MGMT-DNA crosslinking in 16HBE cells.
Results show that allelic frequencies of the MGMT promoter region locus rs1625649 between patients and healthy control groups were statistically significantly different suggesting an association with the occurrence of laryngeal cancer.
Combination of MGMTmethylation/IDH1 (show IDH1 Proteins) mutation is associated with considerably longer overall survival of chemoradiotherapy-treated glioblastoma patients.
MGMT protein expression assessed by immunohistochemistry did not play an important role as a predictive marker for alkylating agents.
Glioblastoma patients with high IFIT1 (show IFIT1 Proteins) and low MGMT expression have an improved prognosis.
Snell, GHKRO, and PAPPA (show PAPPA Proteins)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1 (show NDRG1 Proteins)).
This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG (show C16orf35 Proteins), as a key node in determining a carcinogenic threshold.
Findings suggest that O6-methylguanine-DNA methyltransferase (MGMT)-mediated temozolomide resistance is associated with increased histone acetylation.
Loss of MGMT expression and high Ezrin (show EZR Proteins) protein expression leads to esophageal cancer.
Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.
ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.
Roles of MGMT and MLH1 (show MLH1 Proteins) proteins in alkylation-induced apoptosis and mutagenesis.
Repression of MGMT is associated with precancerous conditions in hyperplastic mucosa adjacent to colon cancer
GAMT (show GAMT Proteins) and AGAT (show GATM Proteins) mRNA are up-regulated 5.4- and 1.9-fold respectively in adult mdx (show DMD Proteins) muscle compared to C57
MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a
, O6-methylguanine-DNA methyltransferase
, methylated-DNA--protein-cysteine methyltransferase
, methylguanine-DNA methyltransferase
, O-6-alkylguanine-DNA alkyltransferase
, 0-6-methylguanine-DNA methyltransferase
, O(6)-alkylguanine-DNA alkyltransferase
, O6-alkylguanine-DNA alkyltransferase
, O6-methylguanine-DNA methyltranferase