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Browse our MGMT Proteins (MGMT)

Full name:
O6-Methylguanine-DNA-Methyltransferase Proteins (MGMT)
On www.antibodies-online.com are 25 O6-Methylguanine-DNA-Methyltransferase (MGMT) Proteins from 10 different suppliers available. Additionally we are shipping MGMT Antibodies (202) and MGMT Kits (29) and many more products for this protein. A total of 268 MGMT products are currently listed.
Synonyms:
Agat, AGT, AI267024
list all proteins Gene Name GeneID UniProt
MGMT 4255  
MGMT 17314 P26187
MGMT 25332 P24528

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MGMT Proteins (MGMT) by Origin

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Top referenced MGMT Proteins

  1. Human MGMT Protein expressed in Escherichia coli (E. coli) - ABIN666723 : Esteller, Gaidano, Goodman, Zagonel, Capello, Botto, Rossi, Gloghini, Vitolo, Carbone, Baylin, Herman: Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. in Journal of the National Cancer Institute 2002 (PubMed)
    Show all 2 references for ABIN666723

More Proteins for MGMT Interaction Partners

Human O6-Methylguanine-DNA-Methyltransferase (MGMT) interaction partners

  1. Efficacy of TMZ in adrenocortical carcinoma cells does not seem to be limited by low methylation of MGMT.

  2. MGMT is involved in gastric carcinogenesis via downregulation of MMP2 (show MMP2 Proteins).

  3. Study suggests that treatment effects of upfront radiotherapy plus concomitant and maintenance temozolomide might offset some of the beneficial effects of cytoreductive surgery in case of a methylated MGMT promoter whereas this unfortunately seems not be true for unmethylated tumors

  4. our results suggest that an aberrant messenger RNA expression may be the outcome of CpG, CHG, and CHH methylation in O(6)-methylguanine-DNA methyltransferase, whereas outcome of CHG and CHH methylation in runt-related transcription factor 3 promoters along with risk factors such as consumption of tobacco, betel nut, and smoking habits in esophageal cancer from Northeast India

  5. Loss of O-6-methylguanine-DNA methyltransferase protein was very frequent in the incidence of esophageal cancer from North Indian patients, and methylation of the promoter region of O-6-methylguanine-DNA methyltransferase was significantly associated in its downregulation

  6. Meta-analysis suggested that MGMT gene-promoter hypermethylation was significantly associated with an increased risk of gastric cancer, especially in Asians.

  7. The meta-analysis results demonstrated that the frequency of MGMT promoter methylation was higher in gastric cancer tissues compared with adjacent tissues and normal tissues (OR=4.06, 95% CI: 2.55-6.46, p<0.001; OR=8.85, 95% CI: 1.15-68.23, p=0.036; respectively). MGMT promoter hypermethylation was significantly associated with tumor-node-metastasis stage, lymph node metastasis, and distant metastasis.

  8. Eleven studies were included to evaluate the relationship between the status of MGMT promoter methylation and glioblastoma patients' survival. [meta-analysis]

  9. Experimental analysis showed that the edema/necrosis volume ratio, tumor/necrosis volume ratio, edema volume, and tumor location and enhancement characteristics were the most significant variables in respect to the status of MGMT promoter methylation in GBM

  10. Data show that patients with MGMT protein promoter methylation and isocitrate dehydrogenase 1 (IDH1 (show IDH1 Proteins)) somatic mutation had a better prognosis than those with MGMT methylation alone.

Mouse (Murine) O6-Methylguanine-DNA-Methyltransferase (MGMT) interaction partners

  1. Snell, GHKRO, and PAPPA (show PAPPA Proteins)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1 (show NDRG1 Proteins)).

  2. This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG (show C16orf35 Proteins), as a key node in determining a carcinogenic threshold.

  3. Findings suggest that O6-methylguanine-DNA methyltransferase (MGMT)-mediated temozolomide resistance is associated with increased histone acetylation.

  4. Loss of MGMT expression and high Ezrin (show EZR Proteins) protein expression leads to esophageal cancer.

  5. Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.

  6. ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.

  7. Roles of MGMT and MLH1 (show MLH1 Proteins) proteins in alkylation-induced apoptosis and mutagenesis.

  8. Repression of MGMT is associated with precancerous conditions in hyperplastic mucosa adjacent to colon cancer

  9. GAMT (show GAMT Proteins) and AGAT (show GATM Proteins) mRNA are up-regulated 5.4- and 1.9-fold respectively in adult mdx (show DMD Proteins) muscle compared to C57

  10. MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

MGMT Protein Profile

Protein Summary

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a

Alternative names and synonyms associated with MGMT

  • O-6-methylguanine-DNA methyltransferase (MGMT)
  • O-6-methylguanine-DNA methyltransferase (Mgmt)
  • Agat protein
  • AGT protein
  • AI267024 protein

Protein level used designations for MGMT

6-O-methylguanine-DNA methyltransferase , O-6-methylguanine-DNA-alkyltransferase , O6-methylguanine-DNA methyltransferase , methylated-DNA--protein-cysteine methyltransferase , methylguanine-DNA methyltransferase , O-6-alkylguanine-DNA alkyltransferase , 0-6-methylguanine-DNA methyltransferase , O(6)-alkylguanine-DNA alkyltransferase , O6-alkylguanine-DNA alkyltransferase , O6-methylguanine-DNA methyltranferase , O6-alkylguanine-DNA-alkyltransferase , O6-methylguanine-DNA-methyltransferase

GENE ID SPECIES
4255 Homo sapiens
17314 Mus musculus
25332 Rattus norvegicus
100733185 Cavia porcellus
100155050 Sus scrofa
616091 Bos taurus
442978 Canis lupus familiaris
423965 Gallus gallus
101106897 Ovis aries
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