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Human MRE11A Protein expressed in Wheat germ - ABIN1311266
Lee, Padget, Curtis, Cowell, Moiani, Sondka, Morris, Jackson, Cockell, Tainer, Austin: MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. in Biology open 2012
cyclin A2 (show CCNA2 Proteins) controlled Mre11 abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 transcripts to mediate polysome loading and translation.
MRE11 complex influences the elimination of oocytes with unrepaired meiotic double-strand breaks post-natally, in addition to its previously described role in double-strand break repair and homologous synapsis during female meiosis.
Inhibiting MRE11 by mirin during meiotic maturation results in anaphase bridges and also increases the number of gammaH2AX (show H2AFX Proteins) foci in metaphase II. Compromised DNA integrity in mirin-treated oocytes indicates a role for MRE11 in chromosome integrity during meiotic maturation.
The authors demonstrate that ATM (show ATM Proteins) can be activated by DNA double-strand breaks in the absence of the Mre11-Rad50 (show RAD50 Proteins)-NBS1 (show NBN Proteins) (MRN) sensor complex.
TRIP13 (show TRIP13 Proteins)-deficient spermatocytes also progress to an H1t (show HIST1H1T Proteins)-positive stage if ATM (show ATM Proteins) activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 (show NBN Proteins) or by elimination of the ATM (show ATM Proteins)-effector kinase CHK2 (show CHEK2 Proteins)
Impairment of Mre11 complex functions promotes the progression of mammary hyperplasias into invasive and metastatic breast cancers
results suggest that the MRE11-RAD50 (show RAD50 Proteins) complex plays important roles in recognition of dsDNA and initiation of STING-dependent signaling, in addition to its role in DNA-damage responses
The critical role of the MRE11 GAR motif in DSB repair is a mechanistic link between post-translational modifications at the MRE11 GAR motif and DSB processing, as well as the ATR/CHK1 (show CHEK1 Proteins) checkpoint signaling.
Mre11 is present in mitochondria where it binds to mtDNA and that the amount in mitochondria varies depending on cellular stress and differentiation.
Data show that CS-mediated SCC (show CYP11A1 Proteins) lethality was mitigated in irradiated gain-of-function Rad50 (show RAD50 Proteins)(s/s) mice, and epistasis studies order Rad50 (show RAD50 Proteins) upstream of Mre11.
although Mre11 is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.
The aim of this study was to assess the interaction between MRE11 and clinicopathologic variables in breast cancer.
The high expression of MRE11-RAD50 (show RAD50 Proteins)-NBS1 (show NBN Proteins) complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer
The expression of DSB repair proteins such as RAD51 (show RAD51 Proteins) and MRE11 was investigated by immunohistochemistry, and associations between RAD51 (show RAD51 Proteins) and MRE11 expression and clinicopathological factors or chemotherapeutic effect were assessed
The MRN complex is essential to restrain MYCN (show MYCN Proteins)-induced replication stress during neural cell proliferation.
This study found a significant trend indicating that the risk increases as the number of adverse alleles increase and significant three-locus interaction model involving NBS1 (show NBN Proteins) rs1805794, MRE11 rs10831234, and ATM (show ATM Proteins) rs227062.
a significant increase in DKC1, RAD50, MRE11 and RPA1 expression in MM cases with high bone marrow infiltration (p=0.03) and a tendency towards cases with advanced ISS stage
Rad51 (show RAD51 Proteins) recombinase (show RAG1 Proteins) prevents Mre11 nuclease (show DCLRE1C Proteins)-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation
The importance of the FGFR2 (show FGFR2 Proteins)-Mre11-DSBR link in cancer progression is suggested by the finding that genotypes of FGFR2 (show FGFR2 Proteins) and Mre11 are associated with survival of breast cancer patients
Loss of the MRE11 protein predicts sensitivity to PARP-inhibitor sensitivity in vitro, defining it as an additional synthetic lethal gene with PARP.
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog\; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
meiotic recombination 11 homolog A
, MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
, MRE11 homolog 1
, MRE11 homolog A
, double-strand break repair protein MRE11A
, meiotic recombination 11 homolog 1
, AT-like disease
, DNA recombination and repair protein
, endo/exonuclease Mre11
, meiotic recombination 11-like protein