Browse our anti-MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Antibodies

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anti-MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Antibodies (MSH2)
On www.antibodies-online.com are 5 MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Antibodies from 2 different suppliers available. Additionally we are shipping MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Proteins (8) and MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Kits (2) and many more products for this protein. A total of 17 MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) products are currently listed.
Synonyms:
AI788990, ATMSH2, CG7895, COCA1, Dmel\CG7895, DmNK-4, DROHOXHK4, DROHOXNK4, FCC1, HNPCC, HNPCC1, HOX, LCFS2, msh-2, msh2, MUTS homolog 2, NK-4, NK-4/msh-2, NK4, NK4/msh-2, NKX2.5, Tin, tin/NK4, wu:fc06b02, wu:fc13e09, zgc:55333
list all antibodies Gene Name GeneID UniProt
Anti-Mouse MSH2 MSH2 17685 P43247
Anti-Rat MSH2 MSH2 81709 P54275
MSH2 4436 P43246

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Top referenced anti-MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Antibodies

  1. Human Monoclonal MSH2 Primary Antibody for WB - ABIN306847 : Fishel, Lescoe, Rao, Copeland, Jenkins, Garber, Kane, Kolodner: The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. in Cell 1994 (PubMed)
    Show all 4 references for 306847

More Antibodies against MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Interaction Partners

Arabidopsis thaliana MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. The expression of AtMutSgamma (MSH7 and MSH2) in Saccharomyces cerevisiae suggest that AtMutSgamma affects yeast genomic stability by recognizing specific mismatches.

  2. The contribution of MutSalpha (MSH2-MSH6) to ultraviolet-induced DNA lesion repair and cell cycle regulation was investigated.

  3. reported that AtMSH2 has a broad range of anti-recombination effects: it suppresses recombination between divergent direct repeats in somatic cells or between homologues from different ecotypes during meiosis

Mouse (Murine) MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. Study shows that MSH2-/- mice develop spontaneous thymic lymphomas.

  2. Data show that in mutS homolog 2 protein Msh2(+/-) mice, azathioprine (Aza) induced a high incidence of microsatellite instability (MSI (show EBP Antibodies)) lymphomas in a dose-dependent manner.

  3. In Msh2-/- mice, red meat enhanced survival compared to control (p<0.01) and lowered total tumour burden compared to resistant starch (p<0.167).

  4. Angptl2 (show ANGPTL2 Antibodies)-induced inflammation increases susceptibility to microenvironmental changes, allowing increased oxidative stress and decreased Msh2 expression.

  5. Gut (show GUSB Antibodies) microbes did not induce colorectal cancer in APC (show APC Antibodies)(Min/+)MSH2(-/-) mice through an inflammatory response or the production of DNA mutagens but rather by providing carbohydrate-derived metabolites such as butyrate that fuel hyperproliferation of MSH2(-/-) colon epithelial cells.

  6. MSH2-MSH3 (show MSH3 Antibodies) suppresses chromosomal instability and modulates the tumor spectrum in p53 (show TP53 Antibodies)-deficient tumorigenesis.

  7. Results suggest that MSH2 is rate limiting for expansion in fragile X (show FMR1 Antibodies) premutation mouse model and that MSH2 levels may be a key factor that accounts for tissue-specific differences in expansion risk.

  8. Toxicity, induced by tert (show TERT Antibodies)-butyl-hydroperoxide and potassium bromate, differs in base excision repair proficient (Mpg (show MPG Antibodies) (+/+), Nth1 (show NTHL1 Antibodies) (+/+)) and deficient (Mpg (show MPG Antibodies) (-/-), Nth1 (show NTHL1 Antibodies) (-/-)) mouse embryonic fibroblasts following Msh2 knockdown, was examined.

  9. Medium-spiny striatal neurons-specific deletion of Msh2 was sufficient to eliminate the vast majority of striatal HTT (show HTT Antibodies) CAG expansions in HTT (show HTT Antibodies) CAG knock-in mice.

  10. Enhanced occupancy of Msh2 and Msh3 (show MSH3 Antibodies) proteins is detected downstream of the FXN (show FXN Antibodies) expanded GAA (show GAA Antibodies) repeat, suggesting a model in which Msh2/3 dimers are recruited to this region to repair mismatches.

Zebrafish MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 Antibodies) genes, mlh1 (show MLH1 Antibodies), msh2, and msh6 (show MSH6 Antibodies), in zebrafish that develop tumors at low frequencies.

Human MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. Genetic changes between MLH1 (show MLH1 Antibodies) and MSH2 were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 and DVL3 (show DVL3 Antibodies) genes (p = 0.034).

  2. Here we demonstrate that in silico saturation mutagenesis and biophysical calculations of the structural stability of the human mismatch repair protein MSH2 correlate with cellular protein levels, turnover and function. Of 24 different MSH2 variants, some of which are linked to Lynch syndrome, a destabilization of as little as 3 kcal/mol (show DUOXA1 Antibodies) is sufficient to cause rapid degradation via the ubiquitin-proteasome pathway.

  3. human Pol alpha interacts with MSH2-MSH6 (show MSH6 Antibodies) complex

  4. In colorectal neoplasms, negative expression of the MMR (show MRC1 Antibodies) proteins MLH1 (show MLH1 Antibodies), MSH2 or MSH6 (show MSH6 Antibodies) was seen in 15% (47 of 313) of the patients. Defect MLH1 (show MLH1 Antibodies) was most common and detected in 12% of the cases. Defect MLH1 (show MLH1 Antibodies) and MSH2 were identified in each patient's normal adjacent mucosa.

  5. unlike MutSbeta, MutSalpha may also act to protect against repeat contractions in the Fmr1 (show FMR1 Antibodies) gene

  6. The expression of genes and proteins related to DNA repair mechanism MLH1 (show MLH1 Antibodies), MSH2 and ATM (show ATM Antibodies) in the normal oral mucosa of chronic smokers was reduced.

  7. The expression of genes and proteins related to DNA repair mechanism MLH1 (show MLH1 Antibodies), MSH2 and ATM (show ATM Antibodies) in the normal oral mucosa of chronic smokers was reduced.

  8. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 (show MLH1 Antibodies) in 40%, MSH2 in 36%, MSH6 (show MSH6 Antibodies) in 18% and PMS2 (show PMS2 Antibodies) in 6% of the families.

  9. There is a positive correlation between the expressions of hMSH2 and hMSH6 (show MSH6 Antibodies) between males (RHO=0.673 and p=0.001) and females with colorectal adenocarcinoma.

  10. Individuals with Lynch syndrome and double-mutants in MSH6 (show MSH6 Antibodies) and MSH2 had normal MSH2 expression, whereas MSH6 (show MSH6 Antibodies) immunoexpression was lost in all evaluable cases.

Fruit Fly (Drosophila melanogaster) MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. Overexpression of Tinman and Pannier resulted in 20% of embryos with ectopic Hand and Sur (show ABCC8 Antibodies) expression. By adding MEF2 (show MYEF2 Antibodies) alongside Tinman and Pannier, an expansion in expression of Hand and Sur (show ABCC8 Antibodies) was observed.

  2. Findings provide mechanistic insight into the brake on myogenesis that occurs during mesoderm specification: twist and tin expression at early stages in turn activate the myogenic inhibitor Him; yet, once Twist or Tin levels decline at mid-embryogenesis, Him is no longer expressed in the mesoderm, and MEF2 (show MYEF2 Antibodies)-dependent muscle differentiation can proceed.

  3. Plasticity in Hox/PBC (show DLAT Antibodies) interaction modes is a common molecular strategy for shaping Hox transcriptional activities.

  4. The enhancers active in the heart progenitor cells and the heart generally are dependent on tinman gene activity, whereas those active in non-cardiac mesoderm are often bound neutrally by Tinman

  5. Genetic interaction analysis shows that spir functionally interacts with Dorsocross, tin, and pannier to properly specify the cardiac fate.

  6. Tin is a direct regulator of midline in fly heart development.

  7. wg and dpp (show TGFb Antibodies) contribute progressively to the elaboration of the expression pattern of the mesoderm-specific homeobox (show PRRX1 Antibodies)-containing gene tinman (tin), and the overlap of wg and dpp (show TGFb Antibodies) in the presence of tin-expressing cells directs cardiac-specific differentiation

  8. We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman, but does not require a differentiated visceral mesoderm.

  9. one of the major functions of mid and H15 during cardioblast development is the re-activation of tin expression at a stage when the induction of tin by Dpp (show TGFb Antibodies) in the dorsal mesoderm has ceased

  10. dSUR is regulated by tinman and plays a protective role against hypoxic stress and pacing-induced heart failure

MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Antigen Profile

Antigen Summary

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2)

  • mismatch repair protein (MSH2) antibody
  • DNA mismatch repair protein Msh2 (MSH2) antibody
  • mutS homolog 2 (E. coli) (Msh2) antibody
  • mutS homolog 2 (E. coli) (msh2) antibody
  • mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2) antibody
  • tinman (tin) antibody
  • AI788990 antibody
  • ATMSH2 antibody
  • CG7895 antibody
  • COCA1 antibody
  • Dmel\CG7895 antibody
  • DmNK-4 antibody
  • DROHOXHK4 antibody
  • DROHOXNK4 antibody
  • FCC1 antibody
  • HNPCC antibody
  • HNPCC1 antibody
  • HOX antibody
  • LCFS2 antibody
  • msh-2 antibody
  • msh2 antibody
  • MUTS homolog 2 antibody
  • NK-4 antibody
  • NK-4/msh-2 antibody
  • NK4 antibody
  • NK4/msh-2 antibody
  • NKX2.5 antibody
  • Tin antibody
  • tin/NK4 antibody
  • wu:fc06b02 antibody
  • wu:fc13e09 antibody
  • zgc:55333 antibody

Protein level used designations for MSH2

mismatch repair protein , DNA mismatch repair protein Msh2 , mutS protein homolog 2 , mismatch repair protein Msh2 , hMSH2 , mutS-like protein 2 , MutS-like protein 2 , CG7895-PA , muscle-specific-homeodomain-2 , tin-PA

GENE ID SPECIES
100268052 Vitis vinifera
821383 Arabidopsis thaliana
17685 Mus musculus
81709 Rattus norvegicus
406845 Danio rerio
4436 Homo sapiens
378799 Gallus gallus
494002 Canis lupus familiaris
100337661 Sus scrofa
533115 Bos taurus
42536 Drosophila melanogaster
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