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anti-Mouse (Murine) MUS81 Antibodies:
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Human Monoclonal MUS81 Primary Antibody for FACS, IP - ABIN108570
Nomura, Adachi, Koyama: Human Mus81 and FANCB independently contribute to repair of DNA damage during replication. in Genes to cells : devoted to molecular & cellular mechanisms 2007
Show all 11 references for ABIN108570
Human Monoclonal MUS81 Primary Antibody for IHC (p), IHC - ABIN151532
Rodrigue, Coulombe, Jacquet, Gagné, Roques, Gobeil, Poirier, Masson: The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy. in Journal of cell science 2013
Show all 2 references for ABIN151532
Human Polyclonal MUS81 Primary Antibody for ICC, IF - ABIN442031
Sun, Brieño-Enríquez, Cornelius, Modzelewski, Maley, Campbell-Peterson, Holloway, Cohen: FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. in Chromosoma 2016
spontaneous mitotic crossovers that occur when FANCM is missing are dependent on MUS312 and either MUS81 or SLX1.
did not find any role for MUS81-MMS4 in meiotic crossing over
Data show that DNA polymerase zeta catalytic subunit REV3 (show REV3L Antibodies) cooperates with ATP-dependent DNA helicase RECQ4A and e ndonuclease MUS81 to repair DNA interstrand cross links.
RECQ4A and MUS81 define RAD5A-independent pathways of DNA repair. RECQ4A and MUS81 act in parallel pathways presumably to resolve replication-associated DNA intermediates.
The role of AtMUS81 in meiotic and mitotic recombination.
AtMUS81 is involved in a secondary subset of meiotic crossovers that are interference insensitive.
The role of MUS81 in the reproduction and growth of A. thaliana, via its expression and metabolism during meiosis, is reported.
Both MUS81-EME1 (show EME1 Antibodies) endonuclease complexes are involved in DNA recombination and repair processes in Arabidopsis.
Mus81 knockdown improves the chemosensitivity of HCC (show FAM126A Antibodies) cells by inducing S-phase arrest and promoting apoptosis through CHK1 (show CHEK1 Antibodies) pathway, suggesting Mus81 as a novel therapeutic target for HCC (show FAM126A Antibodies).
Using mice deficient in both Mus81 and the FA pathway protein FancC (show FANCC Antibodies), we show both proteins cooperate in parallel pathways, as concomitant loss of FancC (show FANCC Antibodies) and Mus81 triggered cell-type-specific proliferation arrest, apoptosis and DNA damage accumulation in utero.
Data indicate that SLX1 and MUS81-EME1 (show EME1 Antibodies) nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4 (show BTBD12 Antibodies).
FBH1 (show FBXO18 Antibodies) helicase (show DNA2 Antibodies) activity is required to eliminate cells with excessive replication stress through the generation of MUS81-induced DNA double-strand breaks.
data indicate that an important role for Chk2 (show CHEK2 Antibodies) is maintaining lymphocyte development and that dual inactivation of Chk2 (show CHEK2 Antibodies) and Mus81 remarkably inhibits cancer
studies demonstrate a critical role for the proper biallelic expression of the mammalian Mus81 in the maintenance of genomic integrity and tumor suppression
Mus81 acts at a late step in the repair of cross-link-induced lesions
Mus81-Eme1 (show EME1 Antibodies)- and Rad54 (show RAD54L Antibodies)-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway
Data suggest that Mus81 suppresses chromosomal instability by converting potentially detrimental replication-associated DNA structures into intermediates that are more amenable to DNA repair.
Analysis of meiotic progression in Mus81-nullizygous mice, and our results implicate the MUS81 pathway as a regulator of crossover frequency and placement in mammals.
Mus81 regulates the rate of DNA replication during normal growth by promoting replication fork progression while reducing the frequency of replication initiation events.
Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 (show BTBD12 Antibodies) scaffold protein.MUS81 function in DNA interstrand crosslinks repair requires interaction with SLX4 (show BTBD12 Antibodies).
The data highlight the importance of Mus81 and Blm in DNA double-strand repair pathways, fertility, development and cancer.
Authors confirmed that HIV-1 Vpr induces degradation of Mus81 although, surprisingly, degradation is independent and genetically separable from Vprs ability to induce G2 arrest.
Results define distinct and temporal roles for MUS81-EME1 (show EME1 Antibodies) and MUS81-EME2 (show EME2 Antibodies) in the maintenance of genome stability.
Our findings reveal a novel RAD52 (show RAD52 Antibodies)/MUS81-dependent mechanism that promotes cell viability and genome integrity in checkpoint-deficient cells, and disclose the involvement of MUS81 to multiple processes after replication stress
While Mus81-Eme1 (show EME1 Antibodies) shares several common features with members of the 5' flap (show ALOX5AP Antibodies) nuclease (show DCLRE1C Antibodies) family, the combined structural, biochemical, and biophysical analyses explain why Mus81-Eme1 (show EME1 Antibodies) preferentially cleaves 3' flap (show ALOX5AP Antibodies) DNA substrates with 5' nicked ends.
In vivo HJ resolution depends on both SLX4 (show BTBD12 Antibodies)-associated MUS81-EME1 (show EME1 Antibodies) and SLX1, suggesting that they are acting in concert in the context of SLX4 (show BTBD12 Antibodies).
The presence of a 5' phosphate terminus at nicks and gaps rendered DNA significantly less susceptible to the cleavage by MUS81-EME2 (show EME2 Antibodies) than its absence.
Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
, crossover junction endonuclease MUS81
, MUS81 endonuclease homolog (S. cerevisiae)
, MUS81 endonuclease homolog
, MUS81 protein
, crossover junction endonuclease MUS81-like
, SLX3 structure-specific endonuclease subunit homolog
, hypothetical protein