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Browse our anti-NTH1 (NTHL1) Antibodies

Full name:
anti-NTH1 Antibodies (NTHL1)
On www.antibodies-online.com are 0 NTH1 (NTHL1) Antibodies from different suppliers available. A total of 0 NTH1 products are currently listed.
Synonyms:
NTH1, OCTS3
list all antibodies Gene Name GeneID UniProt
Anti-Mouse NTHL1 NTHL1 18207  
Anti-Rat NTHL1 NTHL1 29541  
Anti-Human NTHL1 NTHL1 4913 P78549

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More Antibodies against NTH1 Interaction Partners

Mouse (Murine) NTH1 (NTHL1) interaction partners

  1. Toxicity, induced by tert (show TERT Antibodies)-butyl-hydroperoxide and potassium bromate, differs in base excision repair proficient (Mpg (show MPG Antibodies) (+/+), Nth1 (+/+)) and deficient (Mpg (show MPG Antibodies) (-/-), Nth1 (-/-)) mouse embryonic fibroblasts following Msh2 (show MSH2 Antibodies) knockdown, was examined.

  2. These results suggest that Nth1 plays an important role in telomere maintenance and base repair against oxidative stress-induced (show SQSTM1 Antibodies) base modifications.

  3. deficiencies in Ogg1 (show OGG1 Antibodies) and/or Nth1 do not lead to decreased DNA double strand breaks

  4. To determine the significance of thymine glycol repair in mammals, a mouse model with mutated mNth1, a homolog of nth (show APEX1 Antibodies), was made by gene targeting. Mutant mouse liver, instead of mNTH1 activity, had at least 2 novel DNA glycosylase activities against Tg.

  5. To determine the role of murine Nth1 in protecting genomic integrity, a knockout strain was created. No phenotypic changes from wild type were noted due to a novel AP endonuclease DNA repair system.

  6. NEIL1 (show NEIL1 Antibodies) is a back-up glycosylase for NTH1 with unique substrate specificity and tissue-specific expression

  7. ability of nth1 to discriminate between thymine glycol stereoisomers

  8. results indicated that 8-oxoguanine DNA-glycosylase (OGG1 (show OGG1 Antibodies)) and nth (endonuclease III)-like 1(NTH1) are the major DNA glycosylases for the removal of 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA)

  9. The high incidence of tumors in Nth1-/-Neil1 (show NEIL1 Antibodies)-/- mice together with the activating mutation in the K-ras (show HRAS Antibodies) gene of their pulmonary tumors, reveal for the first time, the existence of mutagenic and carcinogenic oxidative damage to DNA which is not 8-OH-Gua (show DDX21 Antibodies).

Human NTH1 (NTHL1) interaction partners

  1. This study extends the description of biallelic mutations in NTHL1 beyond the single c.268C-->T,p.Q90* mutation that was observed previously.

  2. A homozygous loss-of-function germline mutation in the NTHL1 gene predisposes to a new subtype of BER-associated adenomatous polyposis and colorectal cancer.

  3. NTH1 is involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA

  4. substrate selectivity of mammalian NTH1 and the concomitant selective stimulation of activity by APE1 (show APEX1 Antibodies) are indicative of selective repair of oxidative damage in different regions of the genome

  5. search for the factors interacting with NTH1 shows GST (show SLCO6A1 Antibodies)-NTH1 fusion protein precipitates proliferating cell nuclear antigen (PCNA (show PCNA Antibodies)) and p53 (show TP53 Antibodies) as well as XPG (show ERCC5 Antibodies) from human cell-free extracts

  6. NTH1 is a DNA glycosylase that excise 5-formyluracil, 5-hydroxymethyluracil and Thymine glycol in human cells.

  7. Nth1 released 5R,6S 2'-deoxyribonucleoside diastereoisomer (Tg2 (show TGM2 Antibodies)) much more rapidly than cis (show CISH Antibodies) 5S,6R-deoxyribonucleoside diastereoisomer (Tg1) regardless of the opposing purine. Neil1 (show NEIL1 Antibodies) released Thymine glycol non-stereoselectively.

  8. The damage specificity of human homologues of Endo III (hNTHl) and Endo VIII (show COX8A Antibodies) (hNEIL1 and hNEIL2) is compared to elucidate the repair role in cells.

  9. YB-1 (show YBX1 Antibodies) binds specifically to the auto-inhibitory domain of hNTH1, providing a mechanism by which YB-1 (show YBX1 Antibodies) stimulates hNTH1 activity.

  10. Downregulation of NTH1 is associated with gastric cancer.

NTH1 (NTHL1) Antigen Profile

Antigen Summary

The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity.

Alternative names and synonyms associated with NTH1 (NTHL1)

  • nth (endonuclease III)-like 1 (E.coli) (Nthl1) antibody
  • nth endonuclease III-like 1 (E. coli) (NTHL1) antibody
  • NTH1 antibody
  • OCTS3 antibody

Protein level used designations for anti-NTH1 (NTHL1) Antibodies

endonuclease III-like protein 1 , thymine glycol DNA glycosylase/AP lyase , nth endonuclease III-like 1

GENE ID SPECIES
18207 Mus musculus
29541 Rattus norvegicus
4913 Homo sapiens
535203 Bos taurus
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