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Browse our Poly (ADP-Ribose) Polymerase 2 Proteins (PARP2)

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Poly (ADP-Ribose) Polymerase 2 Proteins (PARP2)
On are 7 Poly (ADP-Ribose) Polymerase 2 (PARP2) Proteins from 4 different suppliers available. Additionally we are shipping Poly (ADP-Ribose) Polymerase 2 Antibodies (81) and Poly (ADP-Ribose) Polymerase 2 Kits (3) and many more products for this protein. A total of 98 Poly (ADP-Ribose) Polymerase 2 products are currently listed.
Adprt2, Adprtl2, ADPRTL3, ARTD2, Aspartl2, ATPARP1, C78626, cb996, F16D14.16, F16D14_16, pADPRT-2, PARP-2, poly(ADP-ribose) polymerase 1
list all proteins Gene Name GeneID UniProt
PARP2 10038 Q9UGN5
Rat PARP2 PARP2 290027  
PARP2 11546 O88554

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Poly (ADP-Ribose) Polymerase 2 Proteins (PARP2) by Origin

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Top referenced Poly (ADP-Ribose) Polymerase 2 Proteins

  1. Human PARP2 Protein expressed in Escherichia coli (E. coli) - ABIN1098789 : Karlberg, Hammarström, Schütz, Svensson, Schüler: Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888. in Biochemistry 2010 (PubMed)
    Show all 2 references for ABIN1098789

More Proteins for Poly (ADP-Ribose) Polymerase 2 Interaction Partners

Human Poly (ADP-Ribose) Polymerase 2 (PARP2) interaction partners

  1. The initial affinity between the PARP1 (show PARP1 Proteins), PARP2 and the DNA damaged site appears to influence both the size of the Poly(ADP-Ribose) synthesized and the time of residence of PARylated PARP1 (show PARP1 Proteins) and PARP2 on DNA damages.

  2. Our data suggest for the first time that a SNP in PARP2, rs878156, may together with other genetic variants modulate cancer specific survival in breast cancer patients depending on chemotherapy

  3. Our study differentiates the functions of PARP-2 domains from those of PARP-1 (show PARP1 Proteins), the other major DDR (show DDR1 Proteins)-PARP, and highlights the specialization of the multi-domain architectures of DDR (show DDR1 Proteins)-PARPs.

  4. Interaction of PARP-2 with AP site containing DNA

  5. Identification of ADP-ribosylation sites in PARP2 and the determination of the extent ofpoly(ADP-ribosyl)ated residues in this protein was performed.

  6. Nuclear Smad function is negatively regulated by PARP-1 that is assisted by PARP-2 and positively regulated by PARG during the course of TGFB signaling.

  7. the depletion of PARP-2 leads to lower HDL (show HSD11B1 Proteins) levels which represent a risk factor to cardiovascular diseases.

  8. these findings propose a novel mechanism of PARP-2 in transcriptional regulation involving specific protein-protein interactions and highlight the importance of PARP-2 in the regulation of cell cycle progression.

  9. PARP-1 (show PARP1 Proteins) (but not PARP-2) poly(ADP) ribosylates Snail1 (show SNAI1 Proteins), both in vivo and in vitro, and interacts with Snail1 (show SNAI1 Proteins), an association that is sensitive to PARP inhibitors.

  10. In complex with its inhibitor, the crystal structure of PARP2 alpha-helix 5 that contains glutamate (show GRIN1 Proteins) residue Glu335 is closer to the active site than in both PARP1 (show PARP1 Proteins) and PARP3 (show PARP3 Proteins) and suggests a mechanism for a weak bias toward PARP2.

Mouse (Murine) Poly (ADP-Ribose) Polymerase 2 (PARP2) interaction partners

  1. PARP-2 has an essential role in erythropoiesis by limiting replicative stress in erythroid progenitors.

  2. PARP-1 (show PARP1 Proteins) and -2 play a role in cancer-induced cachexia, thus selective pharmacological inhibition of PARP-1 (show PARP1 Proteins) and -2 may be of interest in clinical settings

  3. the depletion of PARP-2 leads to lower HDL (show HSD11B1 Proteins) levels which represent a risk factor to cardiovascular diseases.

  4. This study represents the first description of a significant role for PARP-2 in neuroinflammation and neurological dysfunction in Experimental autoimmune encephalomyelitis

  5. our data show that PARP-2 can directly regulate base excision repair proteins

  6. Our results show that Parp-2 plays essential roles in the surveillance of genome integrity of stem cell hematopoiesis by orchestrating DNA repair and restraining p53 (show TP53 Proteins)-induced and Puma (show BBC3 Proteins)-mediated apoptosis.

  7. PARP2 activity mobilizes intracellular TRPM2 (show TRPM2 Proteins) channels in a Parp1 (show PARP1 Proteins)-/- background.

  8. Identify PARP-2 as a mediator of doxorubicin toxicity by regulating vascular SIRT1 (show SIRT1 Proteins) activity and mitochondrial biogenesis.

  9. Inhibition of PARP1 (show PARP1 Proteins) and PARP2 (by genetic or pharmacological means) leads to increased TOP2B (show TOP2B Proteins) activity in elongating spermatids.

  10. PARP-2 deletion in mice increases SIRT1 (show SIRT1 Proteins) levels, promotes energy expenditure, and increases mitochondrial content.

Arabidopsis thaliana Poly (ADP-Ribose) Polymerase 2 (PARP2) interaction partners

  1. whilst all isoforms of PARP (show PARP1 Proteins) were localized to the nucleus they are also present in non-nuclear locations with parp1 and parp3 (show PARP3 Proteins) also localised in the cytosol, and parp2 also present in the mitochondria

  2. Studies indicate that a massive and rapid accumulation of a massive and rapid accumulation poly(ADP-ribose) polymerases AtPARP1 and AtPARP2 transcripts was observed upon treatment with ionizing radiation and reactive oxigen species (ROS (show ROS1 Proteins)).

  3. PARP (show PARP1 Proteins) isoforms play a minor role in telomere length maintenance in Arabidopsis.

  4. Evidence suggests a link between the glutathione pool and PARP (show PARP1 Proteins) expression and activity that is perhaps related to the distribution of intracellular glutathione between the cytoplasm and the nucleus. [PARP1]

  5. in PARP2-deficient Arabidopsis plants, the observed abiotic stress resistance can also be explained by alterations in abscisic acid levels that facilitate the induction of a wide set of defense-related genes

Poly (ADP-Ribose) Polymerase 2 (PARP2) Protein Profile

Protein Summary

This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.

Alternative names and synonyms associated with Poly (ADP-Ribose) Polymerase 2 (PARP2)

  • poly (ADP-ribose) polymerase family, member 2 (parp2)
  • poly (ADP-ribose) polymerase 2 (parp2)
  • poly (ADP-ribose) polymerase 2 (PARP2)
  • poly (ADP-ribose) polymerase 2 (Parp2)
  • poly (ADP-ribose) polymerase family, member 2 (Parp2)
  • poly [ADP-ribose] polymerase 2 (PARP1)
  • Adprt2 protein
  • Adprtl2 protein
  • ADPRTL3 protein
  • ARTD2 protein
  • Aspartl2 protein
  • ATPARP1 protein
  • C78626 protein
  • cb996 protein
  • F16D14.16 protein
  • F16D14_16 protein
  • pADPRT-2 protein
  • PARP-2 protein
  • poly(ADP-ribose) polymerase 1 protein

Protein level used designations for PARP2

poly (ADP-ribose) polymerase family, member 2 , ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2 , ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2 , poly [ADP-ribose] polymerase 2 , poly (ADP-ribose) polymerase 2 , poly [ADP-ribose] polymerase 2-like , ADP-ribosyltransferase diphtheria toxin-like 2 , ADPRT-2 , NAD(+) ADP-ribosyltransferase 2 , hPARP-2 , poly (ADP-ribosyl) transferase-like 2 , poly(ADP-ribose) synthetase , poly[ADP-ribose] synthase 2 , poly[ADP-ribose] synthetase 2 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 2 , mPARP-2 , pADPRT-2

386773 Danio rerio
446370 Xenopus laevis
465197 Pan troglodytes
701955 Macaca mulatta
100452137 Pongo abelii
10038 Homo sapiens
475392 Canis lupus familiaris
505828 Bos taurus
290027 Rattus norvegicus
11546 Mus musculus
817690 Arabidopsis thaliana
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