Browse our PMS2 Proteins (PMS2)

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PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) Proteins (PMS2)
On are 6 PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) Proteins from 4 different suppliers available. Additionally we are shipping PMS2 Antibodies (108) and many more products for this protein. A total of 121 PMS2 products are currently listed.
AW555130, HNPCC4, PMS2CL, Pmsl2
list all proteins Gene Name GeneID UniProt
PMS2 5395 P54278
PMS2 18861  
Rat PMS2 PMS2 288479  

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PMS2 Proteins (PMS2) by Origin

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More Proteins for PMS2 Interaction Partners

Human PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) interaction partners

  1. A novel pathogenic PMS2 mutation in a mismatch repair deficiency patient

  2. High PMS2 expression is associated with the development of genetic instability and is linked to tumor aggressiveness and early PSA (show PLAG1 Proteins) recurrence in prostate cancer.

  3. Data suggest that yeast Mlh1 (show MLH1 Proteins)-Mlh3 heterodimer does not exhibit hallmarks of a canonical (structure-selective) Holliday junction resolvase/endonuclease; multiple Mlh1 (show MLH1 Proteins)-Mlh3 heterodimers appear to load onto DNA to form an activated polymer that cleaves DNA; human MLH1 (show MLH1 Proteins)-PMS2 exhibits similar characteristics. (MLH = mutL homolog protein; PMS2 = post meiotic segregation increased 2 protein)

  4. In an individual with mismatch repair deficiency syndrome, PMS2 was found to be homozygously inactivated by a complex chromosomal rearrangement.

  5. show that DNA repair genes (fan1 (show FSCN1 Proteins) and pms2) significantly modify age at onset in Huntington's Disease and Spinocerebellar Ataxias, suggesting a common pathogenic mechanism, which could operate through the observed somatic expansion of repeats

  6. The results of this case study indicated that although FOXL2 (show FOXL2 Proteins) 402C > G mutation determines the development of granulosa cell tumor, PMS2 mutation may be the initial driver of carcinogenesis. Immunohistochemistry-based tumor testing for mismatch repair gene expression may be necessary for granulosa cell tumors to determine their malignant potential or if they are part of Lynch syndrome.

  7. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 (show MLH1 Proteins) in 40%, MSH2 (show MSH2 Proteins) in 36%, MSH6 (show MSH6 Proteins) in 18% and PMS2 in 6% of the families.

  8. molecular mechanisms linking MMR (show MRC1 Proteins) with chemoresistance and suggest that stabilization of PMS2 expression may be useful in overcoming the cisplatin resistance in EOC.

  9. PMS2 mutation carriers with retention of RNA expression developed CRC (show CALR Proteins) 9 years later than those with loss of RNA expression. If confirmed, this finding would justify a delay in surveillance for these cases. Cancer risk was not influenced by a parent-of-origin effect

  10. Individuals who carry a MMR (show MRC1 Proteins) gene (MLH1 (show MLH1 Proteins), MSH2 (show MSH2 Proteins), PMS2 or MSH6 (show MSH6 Proteins)) mutation are at an increased risk of developing cancers at multiple sites, most notably colorectal and endometrial carcinomas.

Mouse (Murine) PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) interaction partners

  1. Pms2/Mlh1 (show MLH1 Proteins) and multiple uracil glycosylases act jointly, each one with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T bases.

  2. Primary function of Pms2 during spermatogenesis is to stabilize Mlh1 levels prior to its critical crossing over function with Mlh3. An intact Pms2 ATPase domain is not essential for male fertility.

  3. Pms2 specifically suppresses large expansions of a pathogenic trinucleotide repeat sequence in neuronal tissues, possibly acting independently of the canonical mismatch repair pathway.

  4. Down-regulation of PMS2 is associated with initiation and growth of neuroblastoma (show ARHGEF16 Proteins) and brain tumour multicellular spheroids.

  5. the integrity of the MLH1 ATPase domain is more critical than the PMS2 ATPase domain for normal DNA mismatch repair functions

  6. Data show that the PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance and tumor suppression.

  7. Role for mismatch repair proteins Msh2 (show MSH2 Proteins), Mlh1 (show MLH1 Proteins), and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions.

  8. We found that MLH1 (show MLH1 Proteins) and PMS2 have functional nuclear localization signals (NLS (show ALDH1A2 Proteins)) and nuclear export sequences, yet nuclear import depended on their C-terminal dimerization to form MutLalpha

  9. Pms2 has a role in the prevention of tandem CC --> TT substitutions induced by ultraviolet radiation and oxidative stress.

  10. Data show partial functional redundancy between MLH3 and PMS2 orthologues for mutation avoidance and show a role for Mlh3 in gastrointestinal and extragastrointestinal tumor suppression.

PMS2 Protein Profile

Protein Summary

This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with PMS2

  • PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2)
  • mismatch repair endonuclease PMS2 (Tsp_08837)
  • postmeiotic segregation increased 2 (S. cerevisiae) (Pms2)
  • AW555130 protein
  • HNPCC4 protein
  • PMS2CL protein
  • Pmsl2 protein

Protein level used designations for PMS2

mismatch repair endonuclease PMS2 , DNA mismatch repair protein PMS2 , H_DJ0042M02.9 , PMS1 protein homolog 2 , PMS2 postmeiotic segregation increased 2

479751 Canis lupus familiaris
100514342 Sus scrofa
10897854 Trichinella spiralis
5395 Homo sapiens
463257 Pan troglodytes
101752182 Gallus gallus
527039 Bos taurus
18861 Mus musculus
288479 Rattus norvegicus
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