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Browse our PMS2 Proteins (PMS2)

Full name:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) Proteins (PMS2)
On www.antibodies-online.com are 6 PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) Proteins from 4 different suppliers available. Additionally we are shipping PMS2 Antibodies (101) and many more products for this protein. A total of 114 PMS2 products are currently listed.
Synonyms:
AW555130, HNPCC4, PMS2CL, Pmsl2
list all proteins Gene Name GeneID UniProt
PMS2 5395 P54278
PMS2 18861  
Rat PMS2 PMS2 288479  

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PMS2 Proteins (PMS2) by Origin

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Human PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) interaction partners

  1. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 (show MLH1 Proteins) in 40%, MSH2 (show MSH2 Proteins) in 36%, MSH6 (show MSH6 Proteins) in 18% and PMS2 in 6% of the families.

  2. molecular mechanisms linking MMR (show MRC1 Proteins) with chemoresistance and suggest that stabilization of PMS2 expression may be useful in overcoming the cisplatin resistance in EOC.

  3. PMS2 mutation carriers with retention of RNA expression developed CRC (show CALR Proteins) 9 years later than those with loss of RNA expression. If confirmed, this finding would justify a delay in surveillance for these cases. Cancer risk was not influenced by a parent-of-origin effect

  4. Individuals who carry a MMR (show MRC1 Proteins) gene (MLH1 (show MLH1 Proteins), MSH2 (show MSH2 Proteins), PMS2 or MSH6 (show MSH6 Proteins)) mutation are at an increased risk of developing cancers at multiple sites, most notably colorectal and endometrial carcinomas.

  5. Germline mutations in MLH1 (show MLH1 Proteins), MSH2 (show MSH2 Proteins), MSH6 (show MSH6 Proteins) and PMS2 have been shown to cause Lynch syndrome. A total of 234 monoallelic PMS2 mutation carriers from 170 families were included.

  6. Loss of MLH-1 (show MLH1 Proteins)/PMS-2 expression was associated with right-colon location, poor and mucinous differentiation and dense lymphocytic infiltration in colorectal adenocarcinoma.

  7. Heterozygous germline mutations in any of the mismatch repair (MMR (show MRC1 Proteins)) genes, MLH1 (show MLH1 Proteins), MSH2 (show MSH2 Proteins), MSH6 (show MSH6 Proteins), and PMS2, cause Lynch syndrome (LS), an autosomal dominant cancer predisposition syndrome.

  8. A reliable tool for accurate molecular analysis of genes containing multiple copies of highly homologous sequences and improved PMS2 molecular analysis for patients with Lynch syndrome.

  9. These results demonstrate a functional role for PMS2 to protect against prostate cancer progression by enhancing apoptosis of prostate cancer cells and by inhibiting cell proliferation, migration, and invasion in vitro as well as tumor growth in vivo.

  10. MutSalpha, proliferating cell nuclear antigen (show PCNA Proteins), and replication factor C activate MutLalpha endonuclease to remove the 1-nucleotide Okazaki fragment flaps

Mouse (Murine) PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) interaction partners

  1. Primary function of Pms2 during spermatogenesis is to stabilize Mlh1 levels prior to its critical crossing over function with Mlh3. An intact Pms2 ATPase domain is not essential for male fertility.

  2. Pms2 specifically suppresses large expansions of a pathogenic trinucleotide repeat sequence in neuronal tissues, possibly acting independently of the canonical mismatch repair pathway.

  3. Down-regulation of PMS2 is associated with initiation and growth of neuroblastoma (show ARHGEF16 Proteins) and brain tumour multicellular spheroids.

  4. the integrity of the MLH1 ATPase domain is more critical than the PMS2 ATPase domain for normal DNA mismatch repair functions

  5. Data show that the PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance and tumor suppression.

  6. Role for mismatch repair proteins Msh2 (show MSH2 Proteins), Mlh1 (show MLH1 Proteins), and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions.

  7. We found that MLH1 (show MLH1 Proteins) and PMS2 have functional nuclear localization signals (NLS (show ALDH1A2 Proteins)) and nuclear export sequences, yet nuclear import depended on their C-terminal dimerization to form MutLalpha

  8. Pms2 has a role in the prevention of tandem CC --> TT substitutions induced by ultraviolet radiation and oxidative stress.

  9. Data show partial functional redundancy between MLH3 and PMS2 orthologues for mutation avoidance and show a role for Mlh3 in gastrointestinal and extragastrointestinal tumor suppression.

  10. In order to determine the effect of Pms2-deficiency on mutation, mutant frequencies in the endogenous Hprt (show HPRT1 Proteins) gene of lymphocytes from male Pms2(-/-), Pms2(+/-), and Pms2(+/+) mice, was measured.

PMS2 Protein Profile

Protein Summary

This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with PMS2

  • PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2)
  • mismatch repair endonuclease PMS2 (Tsp_08837)
  • postmeiotic segregation increased 2 (S. cerevisiae) (Pms2)
  • AW555130 protein
  • HNPCC4 protein
  • PMS2CL protein
  • Pmsl2 protein

Protein level used designations for PMS2

mismatch repair endonuclease PMS2 , DNA mismatch repair protein PMS2 , H_DJ0042M02.9 , PMS1 protein homolog 2 , PMS2 postmeiotic segregation increased 2

GENE ID SPECIES
479751 Canis lupus familiaris
100514342 Sus scrofa
10897854 Trichinella spiralis
5395 Homo sapiens
463257 Pan troglodytes
101752182 Gallus gallus
527039 Bos taurus
18861 Mus musculus
288479 Rattus norvegicus
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