Browse our Polymerase (DNA Directed), eta (POLH) ELISA Kits

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Polymerase (DNA Directed), eta ELISA Kits (POLH)
On www.antibodies-online.com are 0 Polymerase (DNA Directed), eta (POLH) ELISA Kits from different suppliers available. Additionally we are shipping Polymerase (DNA Directed), eta Antibodies (53) and Polymerase (DNA Directed), eta Proteins (5) and many more products for this protein. A total of 61 Polymerase (DNA Directed), eta products are currently listed.
Synonyms:
fc50a12, POLH, RAD30, RAD30A, wu:fc50a12, XP-V, XPV, zgc:136881, zgc:152642
list all ELISA KIts Gene Name GeneID UniProt
Human POLH POLH 5429 Q9Y253
Rat POLH POLH 316235  
Mouse POLH POLH 80905 Q9JJN0

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More ELISA Kits for Polymerase (DNA Directed), eta Interaction Partners

Xenopus laevis Polymerase (DNA Directed), eta (POLH) interaction partners

  1. Error-free insertion in cyclobutane pyrimidine bypass is due mainly to pol eta (translesion synthesis TLS3) in oocyte extracts during DNA replication.

Human Polymerase (DNA Directed), eta (POLH) interaction partners

  1. The current work explores both the fidelity of DNA polymerase eta and the role of the 3rd metal ion (magnesium), by using empirical valence bond simulations.

  2. The results suggest that translesion synthesis by Pol eta can contribute to the accumulation of rCMP in the genome, particularly opposite modified guanines.

  3. the targeting of Poleta to damage sites after UV exposure is regulated by SPARTAN, and this function contributes highly to its DNA-damage tolerance function.

  4. Study shows that the posttranslational modifications of nuclear localization signal of pol eta played a dual role in polymerase switching, where Lys682 deubiquitination promotes the recruitment of pol eta to PCNA (show PCNA ELISA Kits) immediately prior to lesion bypass and Ser687 phosphorylation stimulates its departure from the replication fork immediately after lesion bypass.

  5. The data directly show that, in the human genome, DNA Pol-eta and Rev1 bypass cyclobutane pyrimidine dimers and 6-4PP at replication forks, while only 6-4PP are also tolerated by a Rev3L-dependent gap-filling mechanism, independent of S phase.

  6. p53 (show TP53 ELISA Kits) controls the induction of DNA polymerase eta in DNA damaged human cells. The role of DNA polymerase eta in p53 (show TP53 ELISA Kits)-dependent translesion synthesis.

  7. These results provide important knowledge about the effects of the length and structure of the alkyl group in O(4)-alkylthymidine lesions on the fidelity and efficiency of DNA replication mediated by human DNA polymerase eta.

  8. The described is cooperative motion of a key positively charged residue and metal ions for DNA replication catalyzed by human DNA Polymerase eta.

  9. free energy difference is slightly greater for binding at the 5' thymine position than at the 3' thymine position, presumably because of stabilization arising from the A:T base pair formed at the 3' position of the TTD in previous step of Pol eta function

  10. PolH721 variant present in XP-V patients is unstable. Extra 8 amino acids of PolH721 do not act as degron but induce conformational change of PolH C-terminus exposing its bipartite NLS and sequence close to its UBZ to the ubiquitin/proteasome system.

Mouse (Murine) Polymerase (DNA Directed), eta (POLH) interaction partners

  1. the functions of REV3L in maintaining cell viability, embryonic viability and genomic stability are directly dependent on its polymerase activity, and cannot be ameliorated by an additional deletion of pol eta.

  2. XP-V has a role in adipose tissue senescence and metabolic syndrome

  3. Increase in UV-induced mutations at both G:C and A:T pairs associated with PolH deficiency suggests that PolH contributes to accurate translesion synthesis (TLS (show FUS ELISA Kits)) past both T- & C-containing dimers.

  4. POLH deficiency did not affect the frequency and patterns of C:G mutations and UNG (show UNG ELISA Kits) POLH double deficiency showed an additive effect of single deficiency.

  5. REV1 and Polkappa are involved in DNA damage tolerance via Poleta-REV1 interaction when Poleta fails to bypass its cognate substrates.

  6. These results reveal genetic interactions between REV1 catalytic activity and POLH and identify an alternative pathway in the generation of C to G and G to C transversions.

  7. these data support the existence of PCNA (show PCNA ELISA Kits) ubiquitination-dependent and -independent activation pathways of Poleta during somatic hypermutation and DNA damage tolerance.

  8. inaccurate DNA synthesis by mammalian DNA polymerase eta (pol eta) contributes to somatic hypermutation (SHM (show CNTNAP1 ELISA Kits)) of Ig genes

  9. suggest the involvement of the Pol eta and Pol iota proteins in UV-induced skin carcinogenesis

  10. Results reveal genetic and biochemical interactions between DNA polymerases eta (POLH) and theta (POLQ) and suggest that POLQ might cooperate with POLH to generate some of the A/T mutations during the somatic hypermutation of Ig genes.

Polymerase (DNA Directed), eta (POLH) Antigen Profile

Antigen Summary

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA\; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.

Alternative names and synonyms associated with Polymerase (DNA Directed), eta (POLH)

  • polymerase (DNA directed), eta (polh) Elisa Kit
  • polymerase (DNA directed), eta (POLH) Elisa Kit
  • DNA polymerase eta (Tb10.70.6190) Elisa Kit
  • DNA polymerase eta (LinJ21.0530) Elisa Kit
  • polymerase (DNA directed), eta (Polh) Elisa Kit
  • polymerase (DNA directed), eta (RAD 30 related) (Polh) Elisa Kit
  • fc50a12 Elisa Kit
  • POLH Elisa Kit
  • RAD30 Elisa Kit
  • RAD30A Elisa Kit
  • wu:fc50a12 Elisa Kit
  • XP-V Elisa Kit
  • XPV Elisa Kit
  • zgc:136881 Elisa Kit
  • zgc:152642 Elisa Kit

Protein level used designations for POLH

DNA-directed DNA polymerase eta , DNA polymerase eta , polymerase (DNA directed), eta , DNA polymerase eta-like , polymerase eta , RAD30 homolog A , xeroderma pigmentosum variant type protein , polymerase (DNA directed), eta (RAD 30 related) , xeroderma pigmentosum variant type protein homolog

GENE ID SPECIES
446909 Xenopus laevis
462720 Pan troglodytes
474915 Canis lupus familiaris
513606 Bos taurus
678520 Danio rerio
700772 Macaca mulatta
3661974 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5068792 Leishmania infantum JPCM5
100011953 Monodelphis domestica
100067518 Equus caballus
100124112 Nasonia vitripennis
100357494 Oryctolagus cuniculus
100392158 Callithrix jacchus
100443019 Pongo abelii
100473341 Ailuropoda melanoleuca
395102 Gallus gallus
100558919 Anolis carolinensis
100602084 Nomascus leucogenys
5429 Homo sapiens
316235 Rattus norvegicus
80905 Mus musculus
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