Browse our anti-PRKDC (PRKDC) Antibodies

Full name:
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide Antibodies (PRKDC)
On www.antibodies-online.com are 412 Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) Antibodies from 28 different suppliers available. Additionally we are shipping PRKDC Kits (9) and PRKDC Proteins (8) and many more products for this protein. A total of 437 PRKDC products are currently listed.
Synonyms:
AI326420, AU019811, DNA-PKCS, DNAPDcs, dnapk, dnpk1, DOXNPH, dxnph, hyrc, hyrc1, p350, p460, PRKDC, prkdc-A, scid, slip, xrcc7
list all antibodies Gene Name GeneID UniProt
PRKDC 19090 P97313
PRKDC 5591 P78527
PRKDC    

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All available anti-PRKDC Antibodies

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Top referenced anti-PRKDC Antibodies

  1. Human Polyclonal PRKDC Primary Antibody for EIA - ABIN358415 : Goudelock, Jiang, Pereira, Russell, Sanchez: Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for 358415

  2. Human Monoclonal PRKDC Primary Antibody for IF, IHC (p) - ABIN197619 : Carter, Vancurová, Sun, Lou, DeLeon: A DNA-activated protein kinase from HeLa cell nuclei. in Molecular and cellular biology 1991 (PubMed)
    Show all 5 references for 197619

  3. Human Polyclonal PRKDC Primary Antibody for IP, ELISA - ABIN129603 : Dittmann, Mayer, Wanner, Kehlbach, Rodemann: The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor- and DNA-dependent kinase phosphorylation. in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007 (PubMed)
    Show all 5 references for 129603

  4. Human Monoclonal PRKDC Primary Antibody for IF, IP - ABIN197617 : Han, Malik, Carter, Reeves, Wyche, Hendrickson: DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. in The Journal of biological chemistry 1996 (PubMed)
    Show all 5 references for 197617

  5. Human Monoclonal PRKDC Primary Antibody for IF, IP - ABIN968186 : Araki, Fujimori, Hamatani, Mita, Saito, Mori, Fukumura, Morimyo, Muto, Itoh, Tatsumi, Abe: Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. in Proceedings of the National Academy of Sciences of the United States of America 1997 (PubMed)
    Show all 4 references for 968186

  6. Human Polyclonal PRKDC Primary Antibody for WB - ABIN197394 : Ding, Reddy, Wang, Woods, Douglas, Ramsden, Lees-Miller, Meek: Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. in Molecular and cellular biology 2003 (PubMed)
    Show all 3 references for 197394

  7. Human Polyclonal PRKDC Primary Antibody for WB - ABIN196898 : Chan, Chen, Prithivirajsingh, Kurimasa, Story, Qin, Chen: Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. in Genes & development 2002 (PubMed)
    Show all 3 references for 196898

  8. Human Monoclonal PRKDC Primary Antibody for IF, IHC - ABIN269396 : Shamanna, Hoque, Lewis-Antes, Azzam, Lagunoff, Peery, Mathews: The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining. in Molecular and cellular biology 2011 (PubMed)

  9. Human Monoclonal PRKDC Primary Antibody for ELISA, ICC - ABIN4305550 : Fantini, Huang, Asara, Bagchi, Raychaudhuri: Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. in Molecular biology of the cell 2016 (PubMed)

More Antibodies against PRKDC Interaction Partners

Mouse (Murine) Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.

  2. DNA-PKcs are required to prevent endogenous DNA damage accumulation throughout the adult brain.

  3. AIM2 (show AIM2 Antibodies) reduced Akt (show AKT1 Antibodies) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 Antibodies) inhibitor reduced tumor load in Aim2 (show AIM2 Antibodies)(-/-) mice

  4. PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (show TRIP13 Antibodies) binding partners in head and neck cancer.

  5. NR5A1 (show NR5A1 Antibodies) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (show CTNNB1 Antibodies) accumulation

  6. Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.

  7. These experiments define a novel requirement for 53BP1 (show TP53BP1 Antibodies) in the fusions of DNA-PKcs-deficient telomeres throughout the cell cycle.

  8. data suggest that DNA-PKcs-SIN1 (show MAPKAP1 Antibodies) complexation-mediated Akt (show AKT1 Antibodies) activation (Ser (show SIGLEC1 Antibodies)-473 phosphorylation) is required for mouse osteoblast differentiation

  9. Activated platelets accumulate in the brain rescue apoptotic neuron cells via activation of EGFR and DNA-dependent protein kinase.

  10. DNA-PK and ATM (show ATM Antibodies) acts in parallel upstream of XRCC4 (show XRCC4 Antibodies), regulating through phosphorylation

Human Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.

  2. DNA-PK directly phosphorylates hSSB1 (show SSBP1 Antibodies) at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival.

  3. DNA-PK activity in peripheral blood lymphocytes might be a useful marker for predicting prostate-specific antigen (show KLK3 Antibodies) relapse and urinary toxicity, possibly contributing to personalized treatment of prostate cancer.

  4. Data suggest that the model can replicate amplified p53 (show TP53 Antibodies) responses under DNA-PK inhibition and provide insights into cell fate decision by manipulating p53 (show TP53 Antibodies) dynamics.

  5. These studies clarify the role of PKCdelta (show PKCd Antibodies) in endothelial cell cytoskeleton regulation.

  6. T204 was identified as a main target for ATM (show ATM Antibodies)/DNA-PKcs phosphorylation on human POLL, and this phosphorylation may facilitate the repair of a subset of IR-induced DSBs and the efficient POLL-mediated gap-filling during NHEJ. POLL phosphorylation might favor POLL interaction with the DNA-PK complex at DSBs.

  7. DNA-PKcs inhibitor acriflavine exerts a p53 (show TP53 Antibodies)-dependent synergistic efficacy with melphalan against human cancer cells both in vitro and in vivo.

  8. EBV-LMP1 (show PDLIM7 Antibodies) suppresses the DNA damage response through DNA-PK/AMPK (show PRKAA1 Antibodies) signaling to promote radioresistance in nasopharyngeal carcinoma.

  9. Together, our results provide evidence that acetylation potentially regulates DNA-PKcs.

  10. Inhibiting PRKDC radiosensitizes human osteosarcoma cells.

Xenopus laevis Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. Ku80 (show XRCC5 Antibodies) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 Antibodies); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme

PRKDC Antigen Profile

Antigen Summary

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.

Alternative names and synonyms associated with PRKDC

  • protein kinase, DNA-activated, catalytic polypeptide (PRKDC) antibody
  • protein kinase, DNA activated, catalytic polypeptide (Prkdc) antibody
  • protein kinase, DNA-activated, catalytic polypeptide (prkdc) antibody
  • AI326420 antibody
  • AU019811 antibody
  • DNA-PKCS antibody
  • DNAPDcs antibody
  • dnapk antibody
  • dnpk1 antibody
  • DOXNPH antibody
  • dxnph antibody
  • hyrc antibody
  • hyrc1 antibody
  • p350 antibody
  • p460 antibody
  • PRKDC antibody
  • prkdc-A antibody
  • scid antibody
  • slip antibody
  • xrcc7 antibody

Protein level used designations for PRKDC

protein kinase, DNA-activated, catalytic polypeptide , protein kinase catalytic subunit (DNA-dependent protein kinase) , DNA-dependent protein kinase catalytic subunit , DNA-activated protein kinase catalytic polypeptide , DNA-dependent protein kinase catalytic subunit-like , DNA-PK catalytic subunit , doxorubicin nephropathy , severe combined immunodeficiency , hyper-radiosensitivity of murine scid mutation, complementing 1 , p460 , DNA-PKcs

GENE ID SPECIES
282003 Bos taurus
418814 Gallus gallus
464165 Pan troglodytes
512740 Bos taurus
100125348 Oryctolagus cuniculus
100224961 Taeniopygia guttata
100399020 Callithrix jacchus
100586225 Nomascus leucogenys
100633457 Amphimedon queenslandica
19090 Mus musculus
5591 Homo sapiens
373602 Xenopus laevis
395376 Gallus gallus
474176 Canis lupus familiaris
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