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Browse our anti-PRKDC (PRKDC) Antibodies

Full name:
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide Antibodies (PRKDC)
On www.antibodies-online.com are 371 Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) Antibodies from 25 different suppliers available. Additionally we are shipping PRKDC Kits (4) and PRKDC Proteins (4) and many more products for this protein. A total of 387 PRKDC products are currently listed.
Synonyms:
AI326420, AU019811, DNA-PKCS, DNAPDcs, dnapk, dnpk1, DOXNPH, dxnph, hyrc, hyrc1, p350, p460, PRKDC, prkdc-A, scid, slip, xrcc7
list all antibodies Gene Name GeneID UniProt
PRKDC 19090 P97313
PRKDC 5591 P78527
PRKDC    

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All available anti-PRKDC Antibodies

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Top referenced anti-PRKDC Antibodies

  1. Dog (Canine) Polyclonal PRKDC Primary Antibody for EIA, WB - ABIN401263 : Sawchuk, Mansilla-Soto, Alarcon, Singha, Langen, Bianchi, Lees-Miller, Nussenzweig, Cortes: Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule. in The Journal of biological chemistry 2004 (PubMed)
    Show all 6 references for ABIN401263

  2. Human Polyclonal PRKDC Primary Antibody for EIA - ABIN358415 : Goudelock, Jiang, Pereira, Russell, Sanchez: Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN358415

  3. Human Polyclonal PRKDC Primary Antibody for IP, ELISA - ABIN129603 : Dittmann, Mayer, Wanner, Kehlbach, Rodemann: The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor- and DNA-dependent kinase phosphorylation. in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007 (PubMed)
    Show all 5 references for ABIN129603

  4. Human Monoclonal PRKDC Primary Antibody for IF, IHC (p) - ABIN197619 : Carter, Vancurová, Sun, Lou, DeLeon: A DNA-activated protein kinase from HeLa cell nuclei. in Molecular and cellular biology 1991 (PubMed)
    Show all 5 references for ABIN197619

  5. Human Monoclonal PRKDC Primary Antibody for IF, IP - ABIN197617 : Han, Malik, Carter, Reeves, Wyche, Hendrickson: DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. in The Journal of biological chemistry 1996 (PubMed)
    Show all 5 references for ABIN197617

  6. Human Monoclonal PRKDC Primary Antibody for IF, IP - ABIN968186 : Araki, Fujimori, Hamatani, Mita, Saito, Mori, Fukumura, Morimyo, Muto, Itoh, Tatsumi, Abe: Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. in Proceedings of the National Academy of Sciences of the United States of America 1997 (PubMed)
    Show all 4 references for ABIN968186

  7. Human Polyclonal PRKDC Primary Antibody for WB - ABIN196898 : Ding, Reddy, Wang, Woods, Douglas, Ramsden, Lees-Miller, Meek: Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. in Molecular and cellular biology 2003 (PubMed)
    Show all 3 references for ABIN196898

  8. Human Polyclonal PRKDC Primary Antibody for WB - ABIN197394 : Chan, Chen, Prithivirajsingh, Kurimasa, Story, Qin, Chen: Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. in Genes & development 2002 (PubMed)
    Show all 3 references for ABIN197394

  9. Human Monoclonal PRKDC Primary Antibody for ICC, IHC - ABIN969366 : Durkin, Guo, Fryrear, Mihaylova, Gupta, Belgnaoui, Haoudi, Kupfer, Semmes: HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN969366

More Antibodies against PRKDC Interaction Partners

Mouse (Murine) Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. AIM2 (show AIM2 Antibodies) reduced Akt (show AKT1 Antibodies) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 Antibodies) inhibitor reduced tumor load in Aim2 (show AIM2 Antibodies)(-/-) mice

  2. PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (show TRIP13 Antibodies) binding partners in head and neck cancer.

  3. NR5A1 (show NR5A1 Antibodies) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (show CTNNB1 Antibodies) accumulation

  4. Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.

  5. These experiments define a novel requirement for 53BP1 (show TP53BP1 Antibodies) in the fusions of DNA-PKcs-deficient telomeres throughout the cell cycle.

  6. data suggest that DNA-PKcs-SIN1 (show MAPKAP1 Antibodies) complexation-mediated Akt (show AKT1 Antibodies) activation (Ser (show SIGLEC1 Antibodies)-473 phosphorylation) is required for mouse osteoblast differentiation

  7. Activated platelets accumulate in the brain rescue apoptotic neuron cells via activation of EGFR and DNA-dependent protein kinase.

  8. DNA-PK and ATM (show ATM Antibodies) acts in parallel upstream of XRCC4 (show XRCC4 Antibodies), regulating through phosphorylation

  9. DNA-PKcs is the molecular switch that coordinates end-processing and end-ligation at the DNAends through differential phosphorylations.

  10. DNA-PK/Chk2 (show CHEK2 Antibodies) signaling induces centrosome amplification upon long-term HU treatment, therefore increasing our insight into tumor recurrence after initial chemotherapy.

Human Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. Transient knockdown of PRKDC reduced cell proliferation/survival in HCT116 and DLD1, but not FHC (show FTH1 Antibodies) cells. PRKDC down-regulation induced apoptosis partially through inhibiting AKT (show AKT1 Antibodies) activation, and sensitized HCT116 cells to chemotherapeutic agents

  2. DNA methylation (show HELLS Antibodies) modification plays an important role to regulate the gene expression of XRCC5 (show XRCC5 Antibodies) and XRCC7, from the results that the gene methylation level of the glioma group is higher than that of the normal group

  3. The ends are then closely aligned, which requires XLF (show NHEJ1 Antibodies), a non-catalytic function of XRCC4 (show XRCC4 Antibodies)-LIG4 (show LIG4 Antibodies), and DNA-PK activity

  4. suggested that DNA-PK and PARP (show COL11A2 Antibodies)-dependent recruitment of XRCC1 (show XRCC1 Antibodies) is necessary to effectively protect, repair, and restart stalled replication forks, providing new insight into how genomic stability is preserved

  5. Data show that inhibition of DNA-dependent protein kinase catalytic subunit (DNA-PK) prevents type I DNA topoisomerase (Top1 (show TOP1 Antibodies)) degradation and proteasome activity in camptothecin (CPT (show CHPT1 Antibodies))-treated quiescent WI38 cells.

  6. These results provide new evidence linking cell cycle to bystander responses and demonstrate that DNA-PKcs and ATM (show ATM Antibodies) are two associated factors in co-regulating G2-M phase-related bystander effects.

  7. CD133 and DNAPK regulate MDR1 (show TBC1D9 Antibodies) via the PI3K (show PIK3CA Antibodies)- or Akt (show AKT1 Antibodies)-NF-kappaB (show NFKB1 Antibodies) pathway in multidrug-resistant glioblastoma cells.

  8. c-Myc (show MYC Antibodies) protein functions in the process of DNA double-strand break repair, at least partially, through affecting the ATM (show ATM Antibodies) phosphorylation and DNA-PKcs kinase activity.

  9. DNA-PKcs has a role in cancer metastasis through regulation of secreted proteins involved in migration and invasion

  10. Results show that activated DNA-PKcs is elevated in medullary thyroid tumor samples and its expression correlates with expression of RET (show RET Antibodies) in thyroid tumors.

Xenopus laevis Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. Ku80 (show XRCC5 Antibodies) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 Antibodies); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme

PRKDC Antigen Profile

Antigen Summary

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.

Alternative names and synonyms associated with PRKDC

  • protein kinase, DNA-activated, catalytic polypeptide (PRKDC) antibody
  • protein kinase, DNA activated, catalytic polypeptide (Prkdc) antibody
  • protein kinase, DNA-activated, catalytic polypeptide (prkdc) antibody
  • AI326420 antibody
  • AU019811 antibody
  • DNA-PKCS antibody
  • DNAPDcs antibody
  • dnapk antibody
  • dnpk1 antibody
  • DOXNPH antibody
  • dxnph antibody
  • hyrc antibody
  • hyrc1 antibody
  • p350 antibody
  • p460 antibody
  • PRKDC antibody
  • prkdc-A antibody
  • scid antibody
  • slip antibody
  • xrcc7 antibody

Protein level used designations for PRKDC

protein kinase, DNA-activated, catalytic polypeptide , protein kinase catalytic subunit (DNA-dependent protein kinase) , DNA-dependent protein kinase catalytic subunit , DNA-activated protein kinase catalytic polypeptide , DNA-dependent protein kinase catalytic subunit-like , DNA-PK catalytic subunit , doxorubicin nephropathy , severe combined immunodeficiency , hyper-radiosensitivity of murine scid mutation, complementing 1 , p460 , DNA-PKcs

GENE ID SPECIES
282003 Bos taurus
418814 Gallus gallus
464165 Pan troglodytes
512740 Bos taurus
100125348 Oryctolagus cuniculus
100224961 Taeniopygia guttata
100399020 Callithrix jacchus
100586225 Nomascus leucogenys
100633457 Amphimedon queenslandica
19090 Mus musculus
5591 Homo sapiens
373602 Xenopus laevis
395376 Gallus gallus
474176 Canis lupus familiaris
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