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Browse our anti-PRKDC (PRKDC) Antibodies

Full name:
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide Antibodies (PRKDC)
On www.antibodies-online.com are 407 Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) Antibodies from 26 different suppliers available. Additionally we are shipping PRKDC Kits (9) and PRKDC Proteins (8) and many more products for this protein. A total of 432 PRKDC products are currently listed.
Synonyms:
AI326420, AU019811, DNA-PKCS, DNAPDcs, dnapk, dnpk1, DOXNPH, dxnph, hyrc, hyrc1, p350, p460, PRKDC, prkdc-A, scid, slip, xrcc7
list all antibodies Gene Name GeneID UniProt
PRKDC 19090 P97313
PRKDC 5591 P78527
PRKDC    

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All available anti-PRKDC Antibodies

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Top referenced anti-PRKDC Antibodies

  1. Dog (Canine) Polyclonal PRKDC Primary Antibody for EIA, WB - ABIN401263 : Sawchuk, Mansilla-Soto, Alarcon, Singha, Langen, Bianchi, Lees-Miller, Nussenzweig, Cortes: Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule. in The Journal of biological chemistry 2004 (PubMed)
    Show all 6 references for ABIN401263

  2. Human Polyclonal PRKDC Primary Antibody for EIA - ABIN358415 : Goudelock, Jiang, Pereira, Russell, Sanchez: Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN358415

  3. Human Polyclonal PRKDC Primary Antibody for IP, ELISA - ABIN129603 : Dittmann, Mayer, Wanner, Kehlbach, Rodemann: The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor- and DNA-dependent kinase phosphorylation. in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007 (PubMed)
    Show all 5 references for ABIN129603

  4. Human Monoclonal PRKDC Primary Antibody for IF, IHC (p) - ABIN197619 : Carter, Vancurová, Sun, Lou, DeLeon: A DNA-activated protein kinase from HeLa cell nuclei. in Molecular and cellular biology 1991 (PubMed)
    Show all 5 references for ABIN197619

  5. Human Monoclonal PRKDC Primary Antibody for IF, IP - ABIN197617 : Han, Malik, Carter, Reeves, Wyche, Hendrickson: DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. in The Journal of biological chemistry 1996 (PubMed)
    Show all 5 references for ABIN197617

  6. Human Polyclonal PRKDC Primary Antibody for WB - ABIN196898 : Ding, Reddy, Wang, Woods, Douglas, Ramsden, Lees-Miller, Meek: Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. in Molecular and cellular biology 2003 (PubMed)
    Show all 3 references for ABIN196898

  7. Human Polyclonal PRKDC Primary Antibody for WB - ABIN197394 : Chan, Chen, Prithivirajsingh, Kurimasa, Story, Qin, Chen: Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. in Genes & development 2002 (PubMed)
    Show all 3 references for ABIN197394

  8. Human Monoclonal PRKDC Primary Antibody for ICC, IHC - ABIN969366 : Durkin, Guo, Fryrear, Mihaylova, Gupta, Belgnaoui, Haoudi, Kupfer, Semmes: HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN969366

  9. Human Monoclonal PRKDC Primary Antibody for IF, IHC - ABIN269396 : Shamanna, Hoque, Lewis-Antes, Azzam, Lagunoff, Peery, Mathews: The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining. in Molecular and cellular biology 2011 (PubMed)

  10. Human Monoclonal PRKDC Primary Antibody for ELISA, ICC - ABIN4305550 : Fantini, Huang, Asara, Bagchi, Raychaudhuri: Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. in Molecular biology of the cell 2016 (PubMed)

More Antibodies against PRKDC Interaction Partners

Mouse (Murine) Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. AIM2 (show AIM2 Antibodies) reduced Akt (show AKT1 Antibodies) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 Antibodies) inhibitor reduced tumor load in Aim2 (show AIM2 Antibodies)(-/-) mice

  2. PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (show TRIP13 Antibodies) binding partners in head and neck cancer.

  3. NR5A1 (show NR5A1 Antibodies) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (show CTNNB1 Antibodies) accumulation

  4. Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.

  5. These experiments define a novel requirement for 53BP1 (show TP53BP1 Antibodies) in the fusions of DNA-PKcs-deficient telomeres throughout the cell cycle.

  6. data suggest that DNA-PKcs-SIN1 (show MAPKAP1 Antibodies) complexation-mediated Akt (show AKT1 Antibodies) activation (Ser (show SIGLEC1 Antibodies)-473 phosphorylation) is required for mouse osteoblast differentiation

  7. Activated platelets accumulate in the brain rescue apoptotic neuron cells via activation of EGFR and DNA-dependent protein kinase.

  8. DNA-PK and ATM (show ATM Antibodies) acts in parallel upstream of XRCC4 (show XRCC4 Antibodies), regulating through phosphorylation

  9. DNA-PKcs is the molecular switch that coordinates end-processing and end-ligation at the DNAends through differential phosphorylations.

  10. DNA-PK/Chk2 (show CHEK2 Antibodies) signaling induces centrosome amplification upon long-term HU treatment, therefore increasing our insight into tumor recurrence after initial chemotherapy.

Human Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. Together, our results provide evidence that acetylation potentially regulates DNA-PKcs.

  2. Inhibiting PRKDC radiosensitizes human osteosarcoma cells.

  3. these results suggest that miR (show MLXIP Antibodies)-101 sensitizes pancreatic cancer cells to gemcitabine possibly via downregulating DNA-PKcs.

  4. The bocavirus large viral nonstructural protein NS1 (show PTPN11 Antibodies) is sufficient to induce the DNA damage response and the activation of the host ATM (show ATM Antibodies), ATR (show ANTXR1 Antibodies), and DNAPK.

  5. inhibition of DNAPKcs decreases Pgp expression and sensitizes osteosarcoma cancer stem cells to chemotherapeutic agents in vitro

  6. These results suggested potential usefulness of the phosphorylation status of XRCC4 (show XRCC4 Antibodies) Ser320 as an indicator of DNA-PK functionality in living cells.

  7. Data show that elevated expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Akt3 (show AKT3 Antibodies) protein, and tumor suppressor protein p53 (p53 (show TP53 Antibodies)) in ovarian serous adenocarcinoma tissues are an indication of more advanced disease and worse prognosis.

  8. CDK2 (show CDK2 Antibodies) and DNA-PK regulate PR transcriptional activity by distinct mechanisms.

  9. Results show that under hypoxia, Ku70 (show XRCC6 Antibodies) and DNA-PKcs interact with nuclear RON (show MST1R Antibodies) which activates non-homologous end joining DNA repair conferring chemoresistance.

  10. A significantly different distribution was found in the frequency of PRKDC (rs7003908) genotype between the ESCC group and controls. Individuals homozygous for the C allele had a significant (3.185-fold) increased risk of ESCC.

Xenopus laevis Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. Ku80 (show XRCC5 Antibodies) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 Antibodies); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme

PRKDC Antigen Profile

Antigen Summary

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.

Alternative names and synonyms associated with PRKDC

  • protein kinase, DNA-activated, catalytic polypeptide (PRKDC) antibody
  • protein kinase, DNA activated, catalytic polypeptide (Prkdc) antibody
  • protein kinase, DNA-activated, catalytic polypeptide (prkdc) antibody
  • AI326420 antibody
  • AU019811 antibody
  • DNA-PKCS antibody
  • DNAPDcs antibody
  • dnapk antibody
  • dnpk1 antibody
  • DOXNPH antibody
  • dxnph antibody
  • hyrc antibody
  • hyrc1 antibody
  • p350 antibody
  • p460 antibody
  • PRKDC antibody
  • prkdc-A antibody
  • scid antibody
  • slip antibody
  • xrcc7 antibody

Protein level used designations for PRKDC

protein kinase, DNA-activated, catalytic polypeptide , protein kinase catalytic subunit (DNA-dependent protein kinase) , DNA-dependent protein kinase catalytic subunit , DNA-activated protein kinase catalytic polypeptide , DNA-dependent protein kinase catalytic subunit-like , DNA-PK catalytic subunit , doxorubicin nephropathy , severe combined immunodeficiency , hyper-radiosensitivity of murine scid mutation, complementing 1 , p460 , DNA-PKcs

GENE ID SPECIES
282003 Bos taurus
418814 Gallus gallus
464165 Pan troglodytes
512740 Bos taurus
100125348 Oryctolagus cuniculus
100224961 Taeniopygia guttata
100399020 Callithrix jacchus
100586225 Nomascus leucogenys
100633457 Amphimedon queenslandica
19090 Mus musculus
5591 Homo sapiens
373602 Xenopus laevis
395376 Gallus gallus
474176 Canis lupus familiaris
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