Browse our anti-RAD50 (RAD50) Antibodies

Full name:
anti-RAD50 Homolog (S. Cerevisiae) Antibodies (RAD50)
On www.antibodies-online.com are 130 RAD50 Homolog (S. Cerevisiae) (RAD50) Antibodies from 22 different suppliers available. Additionally we are shipping RAD50 Kits (9) and RAD50 Proteins (7) and many more products for this protein. A total of 151 RAD50 products are currently listed.
Synonyms:
6339, ATRAD50, CG6339, Dmel\\CG6339, Dmrad50, DNA REPAIR-RECOMBINATION PROTEIN, F22D22.28, F22D22_28, hRad50, Mrell, NBSLD, Rad50, Rad50l, RAD502, SPAP4C9.01c
list all antibodies Gene Name GeneID UniProt
RAD50 10111 Q92878
RAD50 19360  
RAD50 64012 Q9JIL8

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Most Popular Reactivities for anti-RAD50 (RAD50) Antibodies

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anti-Human RAD50 Antibodies:

anti-Mouse (Murine) RAD50 Antibodies:

anti-Rat (Rattus) RAD50 Antibodies:

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Top referenced anti-RAD50 Antibodies

  1. Hamster Polyclonal RAD50 Primary Antibody for IP, SimWes - ABIN151086 : Giannini, Ristori, Cerignoli, Rinaldi, Zani, Viel, Ottini, Crescenzi, Martinotti, Bignami, Frati, Screpanti, Gulino: Human MRE11 is inactivated in mismatch repair-deficient cancers. in EMBO reports 2002 (PubMed)
    Show all 29 references for 151086

  2. Human Monoclonal RAD50 Primary Antibody for IF, WB - ABIN968313 : Dolganov, Maser, Novikov, Tosto, Chong, Bressan, Petrini: Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. in Molecular and cellular biology 1996 (PubMed)
    Show all 5 references for 968313

  3. Human Polyclonal RAD50 Primary Antibody for IP, SimWes - ABIN151081 : Carney, Maser, Olivares, Davis, Le Beau, Yates, Hays, Morgan, Petrini: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. in Cell 1998 (PubMed)
    Show all 4 references for 151081

  4. Human Polyclonal RAD50 Primary Antibody for IP, PLA - ABIN258735 : Wen, Scorah, Phear, Rodgers, Rodgers, Meuth: A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner. in Molecular biology of the cell 2008 (PubMed)
    Show all 4 references for 258735

  5. Human Polyclonal RAD50 Primary Antibody for ELISA, WB - ABIN1534488 : Kim, Shin, Seo, Kim, Koh, Kim, Park: Molecular cloning and characterization of splice variants of human RAD50 gene. in Gene 1999 (PubMed)
    Show all 2 references for 1534488

  6. Human Polyclonal RAD50 Primary Antibody for IP, WB - ABIN318941 : Williams, Williams, Tainer: Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. in Biochemistry and cell biology = Biochimie et biologie cellulaire 2007 (PubMed)

More Antibodies against RAD50 Interaction Partners

Fruit Fly (Drosophila melanogaster) RAD50 Homolog (S. Cerevisiae) (RAD50) interaction partners

  1. Study identified a stringent requirement for Mre11 (show MRE11A Antibodies)-Rad50-Nbs (show NLRP2 Antibodies) (MRN) function in telomere protection during early embryonic development.

Xenopus laevis RAD50 Homolog (S. Cerevisiae) (RAD50) interaction partners

  1. MRN (Mre11 (show MRE11A Antibodies), Rad50, and Nbs1 (show NLRP2 Antibodies)) complex, CtIP (show RBBP8 Antibodies), and BRCA1 are required for both the removal of Top2 (show TOP2 Antibodies)-DNA adducts and the subsequent resection of Top2 (show TOP2 Antibodies)-adducted DSB ends.

  2. MRN (MRE11 (show MRE11A Antibodies)-RAD50-NBS1 (show NLRP2 Antibodies)) complex has role in ATR (show ATR Antibodies) activation via TOPBP1 (show TOPBP1 Antibodies) recruitment.

  3. Results indicate a role for the X. laevis Mre11 (show MRE11A Antibodies)/Rad50/Nbs1 (show NLRP2 Antibodies) complex in microhomology-mediated end joining.

  4. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM (show ATM Antibodies) promotes the TopBP1 (show TOPBP1 Antibodies)-dependent activation of ATR (show ATR Antibodies)-ATRIP (show ATRIP Antibodies) in response to double-stranded DNA breaks.

  5. suggests that Mre11 (show MRE11A Antibodies)-Rad50-Nbs1 (show NLRP2 Antibodies) inactivation participates in the down-regulation of damage signaling during checkpoint recovery following double-strand breaks repair.

Arabidopsis thaliana RAD50 Homolog (S. Cerevisiae) (RAD50) interaction partners

  1. Data show that the product of the PHS1 (show PTGS1 Antibodies) gene is a cytoplasmic protein (show BLZF1 Antibodies) that functions by controlling transport of RAD50 from cytoplasm to the nucleus.

  2. The protective role of Rad50 protein on shortened telomeres results from its action in constraining recombination to sister chromatids and thus avoiding end-to-end interactions.

Human RAD50 Homolog (S. Cerevisiae) (RAD50) interaction partners

  1. Mre11 (show MRE11A Antibodies)-Rad50-Nbs1 (show NBN Antibodies) complex initiates DNA double strand break repair.

  2. symmetrical engagement of the Rad50 catalytic head domains with ATP bound at both sites is important for MRN functions in eukaryotic cells.

  3. The results illuminate the important role of Nbs1 (show NBN Antibodies) and CtIP (show RBBP8 Antibodies) in determining the substrates and consequences of human Mre11 (show MRE11A Antibodies)/Rad50 nuclease (show DCLRE1C Antibodies) activities on protein-DNA lesions.

  4. identification of a novel association for longevity in the RAD50/IL13 (show IL13 Antibodies) region on chromosome 5q31.1; the lead SNP rs2706372 is located in the intronic region of the RAD50 gene and is in strong linkage disequilibrium with other associated SNPs close to IL13 (show IL13 Antibodies) and IL5 (show IL5 Antibodies)

  5. the structure of the human Rad50 hook and coiled-coil domains, was determined.

  6. although Mre11 (show MRE11A Antibodies) is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 (show MRE11A Antibodies) is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.

  7. The high expression of MRE11 (show MRE11A Antibodies)-RAD50-NBS1 (show NBN Antibodies) complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer

  8. Germline mutation in RAD50 gene is associated with familial breast cancer.

  9. The MRN complex is essential to restrain MYCN (show MYCN Antibodies)-induced replication stress during neural cell proliferation.

  10. study identified the copy number deletion of RAD50 as a candidate marker for survival

Mouse (Murine) RAD50 Homolog (S. Cerevisiae) (RAD50) interaction partners

  1. The authors demonstrate that ATM (show ATM Antibodies) can be activated by DNA double-strand breaks in the absence of the Mre11 (show MRE11A Antibodies)-Rad50-NBS1 (show NBN Antibodies) (MRN) sensor complex.

  2. Rad50 hook domain strongly influences Mre11 (show MRE11A Antibodies) complex-dependent DDR (show DDR1 Antibodies) signaling, tissue homeostasis, and tumorigenesis.

  3. RAD50, DNA-PKcs (show PRKDC Antibodies) kinase activity, and transcription context are each important to limit incorrect end use during EJ repair of multiple DSBs, but each has distinct roles during repair events requiring end processing

  4. Data show that CS-mediated SCC (show CYP11A1 Antibodies) lethality was mitigated in irradiated gain-of-function Rad50(s/s) mice, and epistasis studies order Rad50 upstream of Mre11 (show MRE11A Antibodies).

  5. MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.

  6. Rad50 mutant mice (Rad50(S/S) mice) exhibited growth defects and cancer predisposition.

  7. the RAD50 LCR has a complex and dual role in Th1 (show HAND1 Antibodies) and Th2 differentiation, communicating early T cell antigen receptor and cytokine signals to the IL-4 (show IL4 Antibodies)/IL-13 (show IL13 Antibodies) locus in both differentiating cell types

  8. enhancer region with four DNase I (show DNASE1 Antibodies) hypersensitive clusters, three of which are highly conserved and predominantly expressed in Th2 cells

  9. The MRE11 (show MRE11A Antibodies)-RAD50-Nijmegen breakage syndrome 1 (NBS1 (show NLRP2 Antibodies) [MRN]) complex accumulates at sites of DNA double-strand breaks (DSBs) in microscopically discernible nuclear foci.

  10. depletion of Rad50 in cultured cells caused extensive DNA damage & death within 3 to 5 days of Rad50 deletion; this was not associated with gross telomere dysfunction, suggesting that telomeric functions of the Mre11 (show MRE11A Antibodies) complex are not required for viability

RAD50 Antigen Profile

Antigen Summary

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

Alternative names and synonyms associated with RAD50

  • RAD50 homolog (S. cerevisiae) (RAD50) antibody
  • CG6339 gene product from transcript CG6339-RE (rad50) antibody
  • RAD50 homolog (rad50) antibody
  • rad50 (rad50) antibody
  • DNA repair protein RAD50 (rad50) antibody
  • Rad50p (RAD50) antibody
  • DNA repair protein Rad50 (rad50) antibody
  • RAD50 recombination protein (RAD50) antibody
  • Rad50 DNA repair/recombination protein (Rad50) antibody
  • DNA repair protein RAD50 (RAD50) antibody
  • Protein RAD-50 (rad-50) antibody
  • RAD50 homolog (S. cerevisiae) (Rad50) antibody
  • 6339 antibody
  • ATRAD50 antibody
  • CG6339 antibody
  • Dmel\\CG6339 antibody
  • Dmrad50 antibody
  • DNA REPAIR-RECOMBINATION PROTEIN antibody
  • F22D22.28 antibody
  • F22D22_28 antibody
  • hRad50 antibody
  • Mrell antibody
  • NBSLD antibody
  • Rad50 antibody
  • Rad50l antibody
  • RAD502 antibody
  • SPAP4C9.01c antibody

Protein level used designations for RAD50

DNA repair protein RAD50 , CG6339-PD , CG6339-PE , rad50-PD , rad50-PE , RAD50 homolog (S. cerevisiae) , RAD50 homolog , GLEAN_15093 , Rad50p , Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining , Rad50 DNA repair/recombination protein , DNA repair protein RAD50-like , mRad50

GENE ID SPECIES
788127 Bos taurus
100063198 Equus caballus
100328725 Oryctolagus cuniculus
37564 Drosophila melanogaster
416329 Gallus gallus
462054 Pan troglodytes
474674 Canis lupus familiaris
495064 Xenopus laevis
658288 Tribolium castaneum
726642 Apis mellifera
779556 Xenopus (Silurana) tropicalis
855471 Saccharomyces cerevisiae S288c
2541635 Schizosaccharomyces pombe 972h-
7200598 Phaeodactylum tricornutum CCAP 1055/1
8250275 Micromonas sp. RCC299
100474262 Ailuropoda melanoleuca
100522666 Sus scrofa
100549534 Meleagris gallopavo
100597285 Nomascus leucogenys
817756 Arabidopsis thaliana
179678 Caenorhabditis elegans
10111 Homo sapiens
19360 Mus musculus
64012 Rattus norvegicus
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