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Human RAD51 Protein expressed in Escherichia coli (E. coli) - ABIN2452204
Kurumizaka, Aihara, Kagawa, Shibata, Yokoyama: Human Rad51 amino acid residues required for Rad52 binding. in Journal of molecular biology 1999
Show all 2 Pubmed References
Human RAD51 Protein expressed in Wheat germ - ABIN1317281
De, Donahue, Tabah, Castro, Mraz, Cruise, Campbell: A novel interaction [corrected] of nucleolin with Rad51. in Biochemical and biophysical research communications 2006
involvement of ZNF281 (show ZNF281 Proteins) in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
Our results thus help establish the functional relevance of the trimeric RAD51-SWI5 (show SWI5 Proteins)-SFR1 (show SFR1 Proteins) complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells.
Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 and 53BP1 (show TP53BP1 Proteins) were recruited to these sites. H2AX (show H2AFX Proteins) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (show H2AFX Proteins) foci formation and DSB repair, whereas H2AX (show H2AFX Proteins) was barely stabilized in response to secondary DSBs, in which gammaH2AX (show H2AFX Proteins) foci were small and DSBs were not efficiently repaired
HOP2 (show PSMC3IP Proteins)-MND1 (show MND1 Proteins) enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.
Rad51 repaired DNA damage.
BRCA2 (show BRCA2 Proteins)-mediated sequestration of nuclear RAD51 serves to prevent inappropriate DNA interactions.
increased Rad51 concentration and homology length interact synergistically to promote 3' extension, presumably as a result of enhanced Brca2 (show BRCA2 Proteins)-mediated Rad51 polymerization
Results suggest that cellular levels of Brca2 (show BRCA2 Proteins) and Rad51 are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53 (show TP53 Proteins), which permits cell growth
FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination.
HELQ (show HEL308 Proteins) interacts directly with the RAD51 paralogue complex BCDX2 and functions in parallel to the Fanconi anaemia pathway to promote efficient homologous recombination at damaged replication forks
Although the presence of RAD51 protein provides essential support for the action of DMC1 (show DMC1 Proteins), these results show no significant effect of the absence of RAD51 strand-exchange activity on meiotic crossing-over rates or patterns in different chromosomal regions or across the whole genome of Arabidopsis, strongly supporting the argument that DMC1 (show DMC1 Proteins) catalyses repair of all meiotic DNA breaks, not only non-sister cross-overs.
The authors find that RBR1 is also required for RAD51 localization to DNA lesions.
RAD51 forms a protein complex with AtRAD51C (show RAD51C Proteins)-AtXRCC3 to facilitate RAD51 localization on chromosomes for meiotic recombination.
Our data demonstrate that RAD51 plays a supporting role for DMC1 (show DMC1 Proteins) in meiotic recombination in the flowering plant, Arabidopsis.
The present study demonstrates for the first time the involvement of a host RAD51 protein in mungbean yellow mosaic India virus replication.
Results demonstrate that DMC1 functions independently and spatially separated from RAD51 during meiosis and that ATR is an integral part of the regular meiotic program.
Establishment and stabilisation of pairing of homologous centromeric and pericentromeric regions depends principally upon DMC1 (show DMC1 Proteins), while pairing and synapsis of euchromatic chromosome arms of homologues requires the presence of RAD51
AtRAD51 is required to ensure the fidelity of homologous recombination during interchromosomal exchanges. It may also be required to ensure the fidelity of homologous recombination in the interchromosomal exchanges initiated by AtDMC1.
AtBRCA2 is required for proper meiotic synapsis and mediates the recruitment of AtRAD51 and AtDMC1.
Study provides the molecular evidence showing that the BRCA2 (show BRCA2 Proteins)-RAD51 complex, known for its function in HR, also plays a direct and specific role in transcription regulation during plant immune responses.
The complete cDNA sequences of the pig RAD51, RAD52 (show RAD52 Proteins), and RAD54 (show RAD54L Proteins) genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.
Meiosis progression and female age affect expression profile of DNA repair RAD51 gene in bovine oocytes.
RAD51 plays a crucial role in halting cell death program induced by ionizing radiation in bovine oocytes.
These results underscore the importance of RAD51 in radioresistance of glioblastoma stem cells
PLAUR (show PLAUR Proteins) to be essential for activation of Checkpoint kinase 1 (CHK1 (show CHEK1 Proteins)); maintenance of cell cycle arrest after DNA damage in a TP53 (show TP53 Proteins)-dependent manner; expression, nuclear import and recruitment to DNA-damage foci of RAD51 recombinase (show RAG1 Proteins), the principal protein involved in the homologous recombination repair pathway.
By antagonizing RAD51 at forks, RADX allows cells to maintain a high capacity for homology-directed repair while ensuring that replication functions of RAD51 are properly regulated. Thus, RADX is essential to achieve the proper balance of RAD51 activity to maintain genome stability.
E3 ligase RFWD3 (show RFWD3 Proteins) functions in timely removal and degradation of RPA (show RPA1 Proteins) and RAD51 to allow homologous recombination progression to subsequent steps following mitomycin C damage.
In the absence of RAD51, the unprotected newly replicated genome is degraded by the exonuclease (show EXO1 Proteins) activity of MRE11 (show MRE11A Proteins), and the fragmented nascent DNA accumulates in the cytosol, initiating an innate immune response.
Architectural plasticity of human BRCA2 (show BRCA2 Proteins)-RPA (show RPA1 Proteins)-RAD51 complexes in DNA break repair has been described.
cyclin D1 (show CCND1 Proteins) and other cyclins such as cyclin A (show CCNA2 Proteins) regulates DNA integrity through RAD51 interaction with the BRCA2 (show BRCA2 Proteins) C-terminal domain
Upregulation of RAD51 and overexpression of Ki67 (show MKI67 Proteins) may be associated with the progression of thyroid cancer.
The data suggest that Rad51 overexpression is correlated with malignant phenotypes of colorectal cancer and may predict poor prognosis for these patients.
Data suggest that RAD51, BRCA2 (show BRCA2 Proteins), and BRCA1 promote stability of nascent DNA at replication forks; RAD51 prevents MRE11 (show MRE11A Proteins) nuclease (show DCLRE1C Proteins)-mediated degradation of nascent ssDNA; BRCA2 (show BRCA2 Proteins) displaces RPA (show RPA1 Proteins) (replication protein A (show GPR153 Proteins)) complex by recruiting RAD51 to protect ssDNA; BRCA1 promotes repair foci following DNA damage and is essential for cell survival. (BRCA = breast cancer recombination protein; RAD51 = Rad51 recombinase (show RAG1 Proteins)) [REVIEW]
Brca2 (show BRCA2 Proteins) and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 (show SMARCAL1 Proteins) and Mre11 (show MRE11A Proteins) predisposes to genome instability.
Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.
By promoting CtIP (show RBBP8 Proteins)-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 (show CDK1 Proteins) inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.
Rad51 has a role at the replication fork protecting DNA from Mre11 (show MRE11A Proteins)-dependent degradation.
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
DNA repair protein XRCC2
, X-ray repair cross-complementing protein 2
, recA/RAD51 family protein
, DNA repair protein RAD51 homolog 1
, RAD51 homolog A
, RAD51 homolog (RecA homolog, E. coli)
, homolog to S.cerevisiae
, DNA repair protein RAD51
, DNA repair protein RAD51-like 1
, BRCA1/BRCA2-containing complex, subunit 5
, RecA, E. coli, homolog of
, RecA-like protein
, recombination protein A
, RAD51 homolog
, DNA repair protein RAD51 homolog A
, RAD51 homolog (RecA homolog)