Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human RAD51 Protein expressed in Escherichia coli (E. coli) - ABIN2452204
Kurumizaka, Aihara, Kagawa, Shibata, Yokoyama: Human Rad51 amino acid residues required for Rad52 binding. in Journal of molecular biology 1999
Show all 2 Pubmed References
Human RAD51 Protein expressed in Wheat germ - ABIN1317281
De, Donahue, Tabah, Castro, Mraz, Cruise, Campbell: A novel interaction [corrected] of nucleolin with Rad51. in Biochemical and biophysical research communications 2006
The anti-recombinase (show RAG1 Proteins) activity of BLM is of general importance for normal retention of RAD51 at DNA double strand break sites and regulation of homologous recombination.
involvement of ZNF281 (show ZNF281 Proteins) in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
Our results thus help establish the functional relevance of the trimeric RAD51-SWI5 (show SWI5 Proteins)-SFR1 (show SFR1 Proteins) complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells.
Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 and 53BP1 (show TP53BP1 Proteins) were recruited to these sites. H2AX (show H2AFX Proteins) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (show H2AFX Proteins) foci formation and DSB repair, whereas H2AX (show H2AFX Proteins) was barely stabilized in response to secondary DSBs, in which gammaH2AX (show H2AFX Proteins) foci were small and DSBs were not efficiently repaired
HOP2 (show PSMC3IP Proteins)-MND1 (show MND1 Proteins) enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.
Rad51 repaired DNA damage.
BRCA2 (show BRCA2 Proteins)-mediated sequestration of nuclear RAD51 serves to prevent inappropriate DNA interactions.
increased Rad51 concentration and homology length interact synergistically to promote 3' extension, presumably as a result of enhanced Brca2 (show BRCA2 Proteins)-mediated Rad51 polymerization
Results suggest that cellular levels of Brca2 (show BRCA2 Proteins) and Rad51 are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53 (show TP53 Proteins), which permits cell growth
FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination.
Although the presence of RAD51 protein provides essential support for the action of DMC1 (show DMC1 Proteins), these results show no significant effect of the absence of RAD51 strand-exchange activity on meiotic crossing-over rates or patterns in different chromosomal regions or across the whole genome of Arabidopsis, strongly supporting the argument that DMC1 (show DMC1 Proteins) catalyses repair of all meiotic DNA breaks, not only non-sister cross-overs.
The authors find that RBR1 is also required for RAD51 localization to DNA lesions.
RAD51 forms a protein complex with AtRAD51C (show RAD51C Proteins)-AtXRCC3 to facilitate RAD51 localization on chromosomes for meiotic recombination.
Our data demonstrate that RAD51 plays a supporting role for DMC1 (show DMC1 Proteins) in meiotic recombination in the flowering plant, Arabidopsis.
The present study demonstrates for the first time the involvement of a host RAD51 protein in mungbean yellow mosaic India virus replication.
Results demonstrate that DMC1 functions independently and spatially separated from RAD51 during meiosis and that ATR is an integral part of the regular meiotic program.
Establishment and stabilisation of pairing of homologous centromeric and pericentromeric regions depends principally upon DMC1 (show DMC1 Proteins), while pairing and synapsis of euchromatic chromosome arms of homologues requires the presence of RAD51
AtRAD51 is required to ensure the fidelity of homologous recombination during interchromosomal exchanges. It may also be required to ensure the fidelity of homologous recombination in the interchromosomal exchanges initiated by AtDMC1.
AtBRCA2 is required for proper meiotic synapsis and mediates the recruitment of AtRAD51 and AtDMC1.
Study provides the molecular evidence showing that the BRCA2 (show BRCA2 Proteins)-RAD51 complex, known for its function in HR, also plays a direct and specific role in transcription regulation during plant immune responses.
The complete cDNA sequences of the pig RAD51, RAD52 (show RAD52 Proteins), and RAD54 (show RAD54L Proteins) genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.
Meiosis progression and female age affect expression profile of DNA repair RAD51 gene in bovine oocytes.
RAD51 plays a crucial role in halting cell death program induced by ionizing radiation in bovine oocytes.
Mutations F86L & E258A affect the multimerization/BRCA2 (show BRCA2 Proteins) binding region of RAD51.Both variants exhibit altered thermal stability,reduced DNA binding affinity,reduced ATPase activity compared to wild-type. F86L efficiently catalyzes DNA strand exchange reactions,whereas strand exchange activity of E258A is severely reduced.Mixtures of either variant with wild-type RAD51 exhibit strong defects in DNA strand exchange activity
Data indicate that lupus autoantibody 3E10 directly binds to the N-terminus of RAD51 recombinase (show RAG1 Proteins), sequesters RAD51 in the cytoplasm, and impedes RAD51 binding to DNA.
Study suggested that RAD51, XRCC1 (show XRCC1 Proteins), and XRCC3 (show XRCC3 Proteins) polymorphisms may be predictive factors for radiation-induced acute toxicity in rectal cancer patients treated with preoperative combined therapy.
n metastatic high grade clear cell carcinoma, this expression was more pronounced. Though we could not demonstrate direct correlation, we showed that epigenetic modification by methylation is associated with decreased genomic translation of Rad51.
our study provides a strong rationale for targeting RAD51-mediated repair to specifically radiosensitize GSCs.
Results showed that the expression of RAD51 is both nuclear and cytoplasmic and it varies among breast cancer (BC) phenotypes. Lack of RAD51 nuclear expression is associated with poor prognostic parameters and shorter survival in invasive BC patients suggesting that RAD51 might play a role in BC development and progression.
USP21 (show USP21 Proteins) interacts with, deubiquitinates and stabilizes BRCA2 (show BRCA2 Proteins) to promote efficient RAD51 loading at DNA double-strand breaks.
CTC1/STN1 (show STON1 Proteins)/TEN1 (show TEN1 Proteins) (CST (show GAL3ST1 Proteins)) deficiency diminishes HU-induced RAD51 foci formation.
These results underscore the importance of RAD51 in radioresistance of glioblastoma stem cells
Brca2 (show BRCA2 Proteins) and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 (show SMARCAL1 Proteins) and Mre11 (show MRE11A Proteins) predisposes to genome instability.
Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.
By promoting CtIP (show RBBP8 Proteins)-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 (show CDK1 Proteins) inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.
Rad51 has a role at the replication fork protecting DNA from Mre11 (show MRE11A Proteins)-dependent degradation.
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
DNA repair protein XRCC2
, X-ray repair cross-complementing protein 2
, recA/RAD51 family protein
, DNA repair protein RAD51 homolog 1
, RAD51 homolog A
, RAD51 homolog (RecA homolog, E. coli)
, homolog to S.cerevisiae
, DNA repair protein RAD51
, DNA repair protein RAD51-like 1
, BRCA1/BRCA2-containing complex, subunit 5
, RecA, E. coli, homolog of
, RecA-like protein
, recombination protein A
, RAD51 homolog
, DNA repair protein RAD51 homolog A
, RAD51 homolog (RecA homolog)