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RAD51D promotes viral replication at early stages of infection
Notwithstanding their clearly established importance for RAD51 (show RAD51 Proteins)-dependent homologous recombination, XRCC2, RAD51B (show Rad51B Proteins) and RAD51D thus also participate in Single-Strand Annealing recombination.
SSN2 and RAD51D are directly involved in regulation of gene expression during plant immune response.
RAD51D and SNI1 have dual roles in pathogenesis-related gene transcription and DNA recombination
RNF138 (show RNF138 Proteins) is a newly identified regulatory component of the HR mediated DNA repair pathway that has implications toward understanding how ubiquitination modifies the functions of the RAD51 (show RAD51 Proteins) paralog protein complex
Cells deficient in RAD51D (a RAD51 (show RAD51 Proteins) paralogue) are extremely sensitive to 6-thioguanine.
RAD51D protects against MLH1 (show MLH1 Proteins)-dependent cytotoxic responses to O(6)-methylguanine
a fragment of Rad51B (show Rad51B Proteins) containing amino acid residues 1-75 interacts with the C-terminus and linker of Rad51C (show RAD51C Proteins), residues 79-376, and this region of Rad51C (show RAD51C Proteins) also interacts with mRad51D and Xrcc3 (show XRCC3 Proteins)
Findings support a crucial role for mammalian RAD51D in normal development, recombination, and maintaining mammalian genome stability.
These cell-based studies are the first evidence that ATP binding and hydrolysis by RAD51D are required for efficient HR repair of DNA interstrand crosslinks.
Rad51d alternative splice variants potentially modulate mechanisms of homologous recombination by sequestering either RAD51C or XRCC2
Interactions of four candidate proteins (SFPQ, NONO (show NONO Proteins), MSH2 (show MSH2 Proteins) and mini chromosome maintenance protein 2) were confirmed by Western blot analysis of co-precipitation eluates and were also verified to form ex vivo complexes with RAD51D.
Results highlight the importance of a functional RAD51D-XRCC2 interaction to promote HR and prevent the development of HGSC.
variants in RAD51D were associated with moderate risks of breast cancer.
of Rad51d mediated by E3 Ligase Rnf138 (show RNF138 Proteins) has a role in the homologous recombination repair pathway
a mutation analysis in 171 high-risk BRCA1 and BRCA2 (show BRCA2 Proteins) negative ovarian cancer patients, to evaluate the frequency of hereditary RAD51C (show RAD51C Proteins) and RAD51D variants in Czech population, is reported.
RAD51C (show RAD51C Proteins) and RAD51D are moderate ovarian cancer susceptibility genes.
endogenous regulation of RAD51D by miR (show MLXIP Proteins)-103/107 was observed in several tumor subtypes; both miR (show MLXIP Proteins)-103 and miR (show MLXIP Proteins)-107 directly target and regulate RAD51 (show RAD51 Proteins) and RAD51D
We aimed to determine the prevalence of germline RAD51D mutations in Spanish breast and ovarian cancer families negative for BRCA1/BRCA2 (show BRCA2 Proteins)
Our data provide additional evidence that RAD51D mutations are enriched among ovarian cancer patients, but are extremely rare among familial breast cancer patients.
loss-of-function mutations in RAD51D predispose to ovarian carcinoma but not to breast carcinoma.
RAD51D is primarily a moderate penetrance susceptibility gene for ovarian cancer, with clinical significance for the carriers.
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene.
, Rad51 DNA recombinase 4
, RAD51D protein
, RAD51 homolog D
, DNA repair protein RAD51 homolog 4
, RAD51-like 3
, RAD51-like protein 3
, recombination repair protein