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Browse our anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) Antibodies

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anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding Antibodies (RECQL2)
On www.antibodies-online.com are 56 RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) Antibodies from 16 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 60 RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding products are currently listed.
Synonyms:
AI846146, recq2, RECQ3, RECQL2, RECQL3, xBLM
list all antibodies Gene Name GeneID UniProt
RECQL2 22427 O09053
RECQL2 7486 Q14191
RECQL2    

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Most Popular Reactivities for anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) Antibodies

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anti-Mouse (Murine) Antibodies:

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All available anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding Antibodies

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Top referenced anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding Antibodies

  1. Human Monoclonal RECQL2 Primary Antibody for IF, WB - ABIN394233 : Ehrenberg, Dratviman-Storobinsky, Avraham-Lubin, Goldenberg-Cohen: Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population. in Molecular vision 2010 (PubMed)
    Show all 5 references for ABIN394233

  2. Human Polyclonal RECQL2 Primary Antibody for EIA, FACS - ABIN955584 : Perry, Asaithamby, Barnebey, Kiamanesch, Chen, Han, Tainer, Yannone: Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for ABIN955584

  3. Human Monoclonal RECQL2 Primary Antibody for ICC, IF - ABIN2668372 : Opresko, Calvo, von Kobbe: Role for the Werner syndrome protein in the promotion of tumor cell growth. in Mechanisms of ageing and development 2007 (PubMed)

More Antibodies against RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding Interaction Partners

Mouse (Murine) RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) interaction partners

  1. A mislocalization of the Wrn mutant protein in the liver endoplasmic reticulum fraction increased oxidative stress in that cellular compartment. Vitamin C reversed this oxidative stress.

  2. The deleterious effects of the helicase-deficient Wrn protein are mediated by the dysfunction of several cellular organelles.

  3. Data suggest that, in the context of Wrn deficiency-related telomere dysfunction, loss of p16Ink4a (show CDKN2A Antibodies) function could prevent cells from senescence.

  4. The FEN1 (show FEN1 Antibodies) E359K germline mutation disrupts the FEN1 (show FEN1 Antibodies)-WRN interaction and FEN1 (show FEN1 Antibodies) GEN (show GEN1 Antibodies) activity, causing aneuploidy-associated cancers.

  5. Studies show that in the context of Myc-associated tumorigenesis, loss of Wrn amplifies the DNA damage response, both in preneoplastic and neoplastic tissue, engaging activation of tumor suppressor pathways.

  6. embryonic fibroblasts lacking a functional Wrn helicase (show DNA2 Antibodies) inhibited the immortalization of Safb1 (show SAFB Antibodies)-null cells. These results indicate that an intact Wrn protein is required for immortalization and tumorigenesis in Safb1 (show SAFB Antibodies)-null mice.

  7. BCR/ABL-mediated stimulation of WRN modulates the efficiency and fidelity of major DSB repair mechanisms to protect leukemia cells from apoptosis and to facilitate genomic instability.

  8. WRN has a role in processing specific types of homologous recombination intermediates as well as an important function in nonhomologous recombination

  9. results demonstrate that WRN loss confers a strong cellular phenotype in early passage human - though not mouse - primary fibroblasts.

  10. Genetic cooperation between this protein and poly(ADP-ribose) polymerase-1 (show PARP1 Antibodies) prevent chromatid breaks, complex chromosomal rearrangements, and cancer in mice.

Human RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) interaction partners

  1. The WRN Cys1367Arg (T>C) polymorphism is not associated with overall cancer risk, although subgroup analyses suggested an association with breast cancer and overall cancer specifically in European populations. [meta-analysis]

  2. The CC genotype of WRN rs1346044 may contribute to an increased risk and a premature onset of breast cancer.

  3. Japanese subjects bearing at least one A allele of rs2230009 of the WRN gene are at a significantly higher risk of femoral fracture, possibly due to decreased bone density.

  4. WRN prefers to act on DNA strand invasion intermediates in a manner that favours strand invasion and exchange.

  5. we provide a proof of concept for applying the external guide sequence (EGS) approach in directing an RNase P RNA to efficiently cleave the WRN mRNA in cultured human cell lines.

  6. Multiplex genetic testing of 90 cancer susceptibility genes disclosed a novel WRN frameshift mutation (p.N1370Tfs*23) in a mother and her 2 (show ERBB2 Antibodies) daughters with cancer and in the youngest unaffected daughter.

  7. PARylation is involved in the recruitment of RECQL5 and WRN to laser-induced DNA damage and RECQL5 and WRN have differential responses to PARylated PARP1 and Poly(ADP-ribose).

  8. WRN knockdown decreased the G(O):A-induced A:T --> C:G mutations, suggesting that WRN may enhance the mutations caused by G(O) in the nucleotide pool

  9. a significant interaction with risk of overall Non Hodgkin lymphoma was observed between WRN rs1346044 and hair dye use before 1980.

  10. knockdown of WRN reduced TNF-alpha (show TNF Antibodies) stimulation-induced activation of the endogenous promoter of IL-8 (show IL8 Antibodies), an NF-kappaB (show NFKB1 Antibodies)-responsive gene, and WRN increased its association with the IL-8 (show IL8 Antibodies) promoter region together with RelA (show NFkBP65 Antibodies)/p50 (show CD40 Antibodies) after TNF-alpha (show TNF Antibodies) stimulation

RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) Antigen Profile

Antigen Summary

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Alternative names and synonyms associated with RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2)

  • RECQL2 (ARALYDRAFT_891126) antibody
  • Bloom syndrome, RecQ helicase-like (blm) antibody
  • Werner syndrome homolog (human) (Wrn) antibody
  • Werner syndrome, RecQ helicase-like (WRN) antibody
  • AI846146 antibody
  • recq2 antibody
  • RECQ3 antibody
  • RECQL2 antibody
  • RECQL3 antibody
  • xBLM antibody

Protein level used designations for RECQL2

RECQL2 , Werner syndrome ATP-dependent helicase homolog , exonuclease WRN , DNA helicase, RecQ-like type 3 , Werner syndrome ATP-dependent helicase , recQ protein-like 2

GENE ID SPECIES
9327212 Arabidopsis lyrata subsp. lyrata
100124311 Xenopus (Silurana) tropicalis
22427 Mus musculus
7486 Homo sapiens
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