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The mutation frequency in AtPolzeta-, AtRev1- or AtPoleta-knockout plants rev3-1, rev1-1 and polh (show POLH ELISA Kits)-1, respectively, were analyzed.
Arabidopsis thaliana disruptants of AtREV3, AtREV1, and/or AtPOLH genes that encode Translesion synthesis-type polymerases.
A translesion synthesis mechanism exists in higher plants and AtREV1 and AtREV7 have important roles in tolerating exposure to DNA-damaging agents. [AtREV1]
A study was conducted to clarify the function of REV1 by in vitro analysis using a primer extension assay.
Transgenic plants that over-expressed or disrupted REV1 showed reduced germination percentage, but the former exhibited a higher stem growth rate than the wild type during development.
REV1 promote PCNA mon (show PCNA ELISA Kits)oubiquitylation after UV radiation through interacting with ubiquitylated RAD18.
Rev1 is essential for the Msh2 (show MSH2 ELISA Kits)-independent generation of these transversions downstream of Ung2 (show UNG ELISA Kits)-induced apyrimidinic sites.
Rev1 operates in the same pathway as Ung (show UNG ELISA Kits), as emphasized by further decreased CSR (show SCARA3 ELISA Kits) in Rev1(-/-)Msh2 (show MSH2 ELISA Kits)(-/-) B cells.
Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) zeta, and Pol kappa (show POLL ELISA Kits)
REV1 and Polkappa are involved in DNA damage tolerance via Poleta-REV1 interaction when Poleta fails to bypass its cognate substrates.
two distinct surfaces of the Rev1 C-terminal domain that separately mediate the assembly of extension and insertion translesion polymerase complexes
These results reveal genetic interactions between REV1 catalytic activity and POLH (show POLH ELISA Kits) and identify an alternative pathway in the generation of C to G and G to C transversions.
REV7 subunit of pol zeta mediated the interaction between REV3 and the REV1 C terminus.
The BRCT domain of Rev1 is involved in regulating DNA replication during the mutagenic bypass of spontaneous and induced DNA lesions.
REV1 expression is required for the methyl methanesulfonate induced mutagenesis phenotype of Pol beta (show POLB ELISA Kits) null mouse embryonic fibroblast cells.
the catalytic function of REV1 is moderately or slightly altered by at least nine genetic variations, and the G4 DNA processing function of REV1 is slightly enhanced by the N373S variation, which might provide the possibility that certain germline missense REV1 variations affect the individual susceptibility to carcinogenesis by modifying the capability of REV1 for replicative bypass past DNA lesions and G4 motifs derived
REV1 can promote PCNA (show PCNA ELISA Kits) monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18 (show RAD18 ELISA Kits).
Data suggest that relatively high affinity binding of PolD3 (show POLD3 ELISA Kits)-RIR (show APBB1 ELISA Kits) motif to Rev1-C-terminal domain displaces subunits from PolN, Pol-iota, or PolK from Rev1 complex and promotes formation of Rev1/PolZ4 assembly with PCNA (show PCNA ELISA Kits) for translesion DNA replication.
Rev1 is indispensable for Translesion synthesis mediated by Poleta, Poliota, and Polkappa (show POLL ELISA Kits) but is not required for TLS (show FUS ELISA Kits) by Polzeta.
Data suggest Rev1 protein recognition mechanism by Fanconi anemia-associated protein 20 (FAAP20).
show that REV1 is a novel binding partner of the tumor suppressor p53 (show TP53 ELISA Kits) and regulates its activity
Our results suggest for the first time that REV1 and REV3L SNPs might serve as potential predictive markers of outcome of cisplatin-based chemotherapy
Structural studies suggest the possible involvement of XRCC1 and its associated repair factors, REV1 in post replication repair.
The results show that human Rev1 disrupts G4 DNA structures and prevents refolding in vitro.
the first structural insights into the regulation of human Rev1 for TLS (show FUS ELISA Kits) polymerases.
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.
DNA repair protein REV1
, rev1-like terminal deoxycytidyl transferase
, REV1 homolog
, REV1- like
, alpha integrin-binding protein 80