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Browse our REV1 Proteins (REV1)

Full name:
REV1, Polymerase (DNA Directed) Proteins (REV1)
On www.antibodies-online.com are 10 REV1, Polymerase (DNA Directed) (REV1) Proteins from 4 different suppliers available. Additionally we are shipping REV1 Antibodies (45) and many more products for this protein. A total of 58 REV1 products are currently listed.
Synonyms:
1110027I23Rik, ARABIDOPSIS THALIANA HOMOLOG OF REVERSIONLESS 1, ATREV1, AU022044, K23L20.9, K23L20_9, REV1L
list all proteins Gene Name GeneID UniProt
REV1 56210 Q920Q2
REV1 51455 Q9UBZ9
Rat REV1 REV1 316344  

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REV1 Proteins (REV1) by Origin

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More Proteins for REV1 Interaction Partners

Arabidopsis thaliana REV1, Polymerase (DNA Directed) (REV1) interaction partners

  1. The mutation frequency in AtPolzeta-, AtRev1- or AtPoleta-knockout plants rev3-1, rev1-1 and polh (show POLH Proteins)-1, respectively, were analyzed.

  2. Arabidopsis thaliana disruptants of AtREV3, AtREV1, and/or AtPOLH genes that encode Translesion synthesis-type polymerases.

  3. A translesion synthesis mechanism exists in higher plants and AtREV1 and AtREV7 have important roles in tolerating exposure to DNA-damaging agents. [AtREV1]

  4. A study was conducted to clarify the function of REV1 by in vitro analysis using a primer extension assay.

  5. Transgenic plants that over-expressed or disrupted REV1 showed reduced germination percentage, but the former exhibited a higher stem growth rate than the wild type during development.

Mouse (Murine) REV1, Polymerase (DNA Directed) (REV1) interaction partners

  1. Rev1 is essential for the Msh2 (show MSH2 Proteins)-independent generation of these transversions downstream of Ung2 (show UNG Proteins)-induced apyrimidinic sites.

  2. Rev1 operates in the same pathway as Ung (show UNG Proteins), as emphasized by further decreased CSR (show SCARA3 Proteins) in Rev1(-/-)Msh2 (show MSH2 Proteins)(-/-) B cells.

  3. Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) zeta, and Pol kappa (show POLL Proteins)

  4. REV1 and Polkappa are involved in DNA damage tolerance via Poleta-REV1 interaction when Poleta fails to bypass its cognate substrates.

  5. two distinct surfaces of the Rev1 C-terminal domain that separately mediate the assembly of extension and insertion translesion polymerase complexes

  6. These results reveal genetic interactions between REV1 catalytic activity and POLH (show POLH Proteins) and identify an alternative pathway in the generation of C to G and G to C transversions.

  7. REV7 subunit of pol zeta mediated the interaction between REV3 and the REV1 C terminus.

  8. The BRCT domain of Rev1 is involved in regulating DNA replication during the mutagenic bypass of spontaneous and induced DNA lesions.

  9. REV1 expression is required for the methyl methanesulfonate induced mutagenesis phenotype of Pol beta (show POLB Proteins) null mouse embryonic fibroblast cells.

  10. Results indicate a catalytic role of Rev1 in incorporating deoxycytidine residues, most likely opposite abasic nucleotides, during somatic hypermutation.

Human REV1, Polymerase (DNA Directed) (REV1) interaction partners

  1. Data suggest that relatively high affinity binding of PolD3 (show POLD3 Proteins)-RIR (show APBB1 Proteins) motif to Rev1-C-terminal domain displaces subunits from PolN, Pol-iota (show POLM Proteins), or PolK (show PAPD7 Proteins) from Rev1 complex and promotes formation of Rev1/PolZ4 assembly with PCNA (show PCNA Proteins) for translesion DNA replication.

  2. Rev1 is indispensable for Translesion synthesis mediated by Poleta, Poliota, and Polkappa (show POLL Proteins) but is not required for TLS (show FUS Proteins) by Polzeta.

  3. Data suggest Rev1 protein recognition mechanism by Fanconi anemia-associated protein 20 (FAAP20).

  4. show that REV1 is a novel binding partner of the tumor suppressor p53 (show TP53 Proteins) and regulates its activity

  5. Our results suggest for the first time that REV1 and REV3L SNPs might serve as potential predictive markers of outcome of cisplatin-based chemotherapy

  6. Structural studies suggest the possible involvement of XRCC1 and its associated repair factors, REV1 in post replication repair.

  7. The results show that human Rev1 disrupts G4 DNA structures and prevents refolding in vitro.

  8. the first structural insights into the regulation of human Rev1 for TLS (show FUS Proteins) polymerases.

  9. Rev1 but not Poleta depletion is epistatic to the lack of PCNA (show PCNA Proteins) ubiquitination.

  10. analysis of the crystal structure of the ternary complex composed of the C-terminal domain of human REV1, REV7, and a REV3 fragment

REV1 Protein Profile

Protein Summary

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.

Alternative names and synonyms associated with REV1

  • DNA repair protein REV1 (REV1)
  • HIG1 hypoxia inducible domain family, member 1C (HIGD1C)
  • REV1 homolog (S. cerevisiae) (Rev1)
  • REV1, polymerase (DNA directed) (REV1)
  • REV1, polymerase (DNA directed) (Rev1)
  • 1110027I23Rik protein
  • ARABIDOPSIS THALIANA HOMOLOG OF REVERSIONLESS 1 protein
  • ATREV1 protein
  • AU022044 protein
  • K23L20.9 protein
  • K23L20_9 protein
  • REV1L protein

Protein level used designations for REV1

DNA repair protein REV1 , rev1-like terminal deoxycytidyl transferase , AIBP80 , REV1 homolog , REV1- like , alpha integrin-binding protein 80

GENE ID SPECIES
834504 Arabidopsis thaliana
100848305 Bos taurus
56210 Mus musculus
51455 Homo sapiens
316344 Rattus norvegicus
418703 Gallus gallus
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