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Data show that three structure-selective endonucleases, SLX1-SLX4, MUS81-EME1, and GEN1, define two pathways of Holliday junctions (HJs) resolution in HeLa cells.
Data indicate that SLX1 and MUS81 (show MUS81 ELISA Kits)-EME1 (show EME1 ELISA Kits) nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4 (show BTBD12 ELISA Kits).
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication\; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene.
GIY-YIG domain containing
, GIY-YIG domain-containing protein 1
, structure-specific endonuclease subunit SLX1
, GIY-YIG domain containing 2