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The results show that Topo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1 (show RMI1 ELISA Kits)-RMI2 (show RMI2 ELISA Kits), and that the processivity of resection is reliant on the Topo IIIalpha-RMI1 (show RMI1 ELISA Kits)-RMI2 (show RMI2 ELISA Kits) complex.
hTOP3alpha interacts with p53 (show TP53 ELISA Kits), regulates p53 (show TP53 ELISA Kits) and p21 (show CDKN1A ELISA Kits) expression, and contributes to the p53 (show TP53 ELISA Kits)-mediated tumor suppression
MPS1 (show IDUA ELISA Kits) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2 (show RMI2 ELISA Kits)) at serine 112 is essential for BLM-Topo III alpha-RMI1 (show RMI1 ELISA Kits)-RMI2 (show RMI2 ELISA Kits) (BTR) protein complex function upon spindle assembly checkpoint (SAC (show ADCY10 ELISA Kits)) activation during mitosis
TOP3A, a new partner gene fused to MLL (show MLL ELISA Kits) in an adult patient with de novo acute myeloid leukaemia.
human topoisomerase IIIalpha functions as a decatenase with the assistance of BLM and RMI1 (show RMI1 ELISA Kits) to facilitate the processing of homologous recombination intermediates without crossing over as a mechanism to preserve genome integrity
G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells
The Bloom's syndrome helicase stimulates the activity of topoisomerase IIIalpha
The effects of TOP3 on telomere binding in human and S. cerevisiae cells are reported.
BLM, Topo IIIalpha, and BLAP75 (show RMI1 ELISA Kits) constitute a dissolvasome complex that processes HR intermediates to limit DNA crossover formation
BLM is stably associated with TOP3A.
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.
DNA topoisomerase 3-alpha
, DNA topoisomerase III alpha
, topo III-alpha
, Top IIIa
, topoisomerase (DNA) 3 alpha
, topoisomerase 3 alpha