Browse our anti-TP53BP1 (TP53BP1) Antibodies

Full name:
anti-Tumor Protein P53 Binding Protein 1 Antibodies (TP53BP1)
On are 239 Tumor Protein P53 Binding Protein 1 (TP53BP1) Antibodies from 24 different suppliers available. Additionally we are shipping TP53BP1 Kits (10) and TP53BP1 Proteins (3) and many more products for this protein. A total of 254 TP53BP1 products are currently listed.
53BP1, m53BP1, MGC160112, p202, Tp53bp1, Trp53bp1
list all antibodies Gene Name GeneID UniProt
TP53BP1 27223 P70399
TP53BP1 7158 Q12888
TP53BP1 296099  

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anti-Mouse (Murine) TP53BP1 Antibodies:

anti-Human TP53BP1 Antibodies:

anti-Rat (Rattus) TP53BP1 Antibodies:

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Top referenced anti-TP53BP1 Antibodies

  1. Fish Polyclonal TP53BP1 Primary Antibody for ChIP, FACS - ABIN151770 : Riballo, Kühne, Rief, Doherty, Smith, Recio, Reis, Dahm, Fricke, Krempler, Parker, Jackson, Gennery, Jeggo, Löbrich: A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. in Molecular cell 2004 (PubMed)
    Show all 272 references for 151770

  2. Human Polyclonal TP53BP1 Primary Antibody for ChIP, ICC - ABIN151771 : Silverman, Takai, Buonomo, Eisenhaber, de Lange: Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. in Genes & development 2004 (PubMed)
    Show all 70 references for 151771

  3. Human Polyclonal TP53BP1 Primary Antibody for ICC, IF - ABIN152191 : Murga, Jaco, Fan, Soria, Martinez-Pastor, Cuadrado, Yang, Blasco, Skoultchi, Fernandez-Capetillo: Global chromatin compaction limits the strength of the DNA damage response. in The Journal of cell biology 2007 (PubMed)
    Show all 65 references for 152191

  4. Human Polyclonal TP53BP1 Primary Antibody for ICC, FACS - ABIN151311 : Kang, Lee, Hoan, Sohn, Chang, You: Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage. in The Journal of biological chemistry 2009 (PubMed)
    Show all 11 references for 151311

  5. Human Monoclonal TP53BP1 Primary Antibody for BI, WB - ABIN968860 : Iwabuchi, Bartel, Li, Marraccino, Fields: Two cellular proteins that bind to wild-type but not mutant p53. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Show all 3 references for 968860

  6. Human Monoclonal TP53BP1 Primary Antibody for FACS, IHC - ABIN1724821 : Nakada, Yonamine, Matsuo: RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1. in Cancer research 2012 (PubMed)
    Show all 2 references for 1724821

  7. Human Polyclonal TP53BP1 Primary Antibody for IF (p), IHC (p) - ABIN682993 : Cai, Cao, Zhang, Xue, Zhang, Zhou, Zhou, Sun, Fu: Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. in The Journal of biological chemistry 2015 (PubMed)

More Antibodies against TP53BP1 Interaction Partners

Mouse (Murine) Tumor Protein P53 Binding Protein 1 (TP53BP1) interaction partners

  1. this study shows that 53BP1 is required for three-dimensional organization of the immunoglobulin heavy chain locus and provides a plausible explanation for the link with 53BP1 enforcement of deletional immunoglobulin class switch recombination

  2. Genomic instability can be rescued by the deletion of Trp53bp1, which encodes the DNA damage response factor 53BP1, and mice expressing RING-less BRCA1 (show BRCA1 Antibodies) do not show an increased susceptibility to tumors in the absence of 53BP1.

  3. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (show RAD51 Antibodies) and 53BP1 were recruited to these sites. H2AX (show H2AFX Antibodies) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (show H2AFX Antibodies) foci formation and DSB repair, whereas H2AX (show H2AFX Antibodies) was barely stabilized in response to secondary DSBs, in which gammaH2AX (show H2AFX Antibodies) foci were small and DSBs were not efficiently repaired

  4. Study showed that mammalian cells use microtubules in the cytoplasm to promote the mobility of sites of DNA damage in the nucleus; molecular details of this process remain to be determined, the main players, including the MOB (show SGMS1 Antibodies) domain of 53BP1, the linker of the nucleoskeleton, and cytoskeleton complex, kinesins, and microtubules are now known, allowing further study.

  5. These experiments define a novel requirement for 53BP1 in the fusions of DNA-PKcs (show PRKDC Antibodies)-deficient telomeres throughout the cell cycle.

  6. Study concludes that only the 53BP1 status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (show LMNA Antibodies) deficiency, which was not observed for heterochromatin-related proteins HP1beta (show CBX1 Antibodies) and BMI1 (show BMI1 Antibodies).

  7. Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor (show E2F1 Antibodies) target genes and allows pRb (show PGR Antibodies) activity to be effectively integrated with the DNA damage response.

  8. study uncovers novel ATM (show ATM Antibodies)-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection

  9. Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 (show RIF1 Antibodies) and PTIP (show PAXIP1 Antibodies).

  10. Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination

Human Tumor Protein P53 Binding Protein 1 (TP53BP1) interaction partners

  1. Results provide evidence that 53BP1 is involved in breast cancer cells resistance for PARP (show COL11A2 Antibodies) inhibitor; its depletion causes resistance in ATM (show ATM Antibodies)-deficient tumor cells.

  2. Ubiquitin ligases RNF168 (show RNF168 Antibodies), RNF169 (show RNF169 Antibodies), and RAD18 (show RAD18 Antibodies) specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 chromatin recruitment may be activated by RNF168 (show RNF168 Antibodies) and blocked by RNF169 (show RNF169 Antibodies) and RAD18 (show RAD18 Antibodies).

  3. 53BP1 embodies two distinct activities: it can act as a DNA repair factor on the chromatin that flanks double-strand DNA repairs, and it promotes optimal p53 (show TP53 Antibodies) activity.

  4. Ras-induced senescent cells are hindered in their ability to recruit BRCA1 and 53BP1 to DNA damage sites. Whereas BRCA1 is downregulated at transcripts levels, 53BP1 loss is caused by activation of cathepsin L (show CTSL1 Antibodies)-mediated degradation of 53BP1 protein. we discovered a marked downregulation of vitamin D receptor (VDR) during OIS, and a role for the vitamin D/VDR (show CYP27B1 Antibodies) axis regulating the levels of these DNA repair

  5. 53BP1-USP28 (show USP28 Antibodies) cooperation is essential for normal p53 (show TP53 Antibodies)-promoter element interactions and gene transactivation-associated events, yet dispensable for 53BP1-dependent DNA double-strand repair regulation.

  6. TIP60 (show KAT5 Antibodies) complex regulates bivalent chromatin recognition/modification by 53BP1 through direct H4K20me binding and H2AK15 acetylation.

  7. findings identify TIRR as a new factor that influences double-strand break repair using a unique mechanism of masking the histone methyl-lysine binding function of 53BP1

  8. Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer.

  9. interplay between 53BP1/NHEJ and BRCA1/HR is of great relevance for tumor treatment, as the 53BP1 status would be highly important for the treatment response of BRCA1-associated tumors.

  10. Exhaustion of 53BP1 by increasing the load of double strand breaks suppresses RAD51 (show RAD51 Antibodies) accumulation in repair foci during S and G2.

TP53BP1 Antigen Profile

Antigen Summary

May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage (By similarity).

Alternative names and synonyms associated with TP53BP1

  • tumor protein p53 binding protein 1 (TP53BP1) antibody
  • tumor protein p53 binding protein 1 (tp53bp1) antibody
  • tumor protein p53 binding protein 1 (predicted), 5 prime (TP53BP1) antibody
  • transformation related protein 53 binding protein 1 (Trp53bp1) antibody
  • tumor protein p53 binding protein 1 (Tp53bp1) antibody
  • 53BP1 antibody
  • m53BP1 antibody
  • MGC160112 antibody
  • p202 antibody
  • Tp53bp1 antibody
  • Trp53bp1 antibody

Protein level used designations for TP53BP1

tumor protein p53 binding protein 1 , tumor protein p53 binding protein, 1 , tumor suppressor p53-binding protein 1-like , tumor protein p53 binding protein 1 (predicted), 5 prime , tumor protein p53 binding protein 1 (predicted), 3 prime , murine p53-binding protein , p53-binding protein 1 , p53BP1 , transformation related protein 53 binding-protein 1 , tumor suppressor p53-binding protein 1 , tumor protein 53-binding protein, 1 , tumor protein p53-binding protein, 1 , transformation related protein 53 binding protein 1

415589 Gallus gallus
467668 Pan troglodytes
478274 Canis lupus familiaris
509111 Bos taurus
100137429 Papio anubis
100468474 Ailuropoda melanoleuca
100490124 Xenopus (Silurana) tropicalis
100550605 Meleagris gallopavo
100607698 Nomascus leucogenys
100328680 Oryctolagus cuniculus
27223 Mus musculus
7158 Homo sapiens
296099 Rattus norvegicus
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