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XRCC1 and PNKP (show PNKP ELISA Kits) interact via a high-affinity phosphorylation-dependent interaction site in XRCC1 and a forkhead-associated domain in PNKP (show PNKP ELISA Kits). Data suggest a second PNKP (show PNKP ELISA Kits) interaction site in XRCC1 that binds PNKP (show PNKP ELISA Kits) with lower affinity and independently of XRCC1 phosphorylation. (XRCC1 = X-ray repair cross complementing protein 1; PNKP (show PNKP ELISA Kits) = polynucleotide kinase 3'-phosphatase (show PNKP ELISA Kits))
APEH (show APEH ELISA Kits) interacts with the amino-terminal domain of XRCC1. Localization of APEH (show APEH ELISA Kits) at sites of nuclear damage is mediated by direct interaction with XRCC1.
XRCC1 Arg194 allele is a predicting factor for renal cell carcinoma.
this updated and cumulative meta-analysis indicated that XRCC1 Arg194Trp polymorphism was associated with increased risk for glioma
Results show that some polymorphic variants in XRCC1 and OGG1 (show OGG1 ELISA Kits) are associated with increased DNA damage in Alzheimer's Disease.
The interaction of OGG1 (show OGG1 ELISA Kits) and XRCC1 DNA repair polymorphisms and arsenic exposure enhances telomeric DNA damage.
either PARP1 (show PARP1 ELISA Kits) or PARP2 (show PARP2 ELISA Kits) are sufficient for near-normal XRCC1 recruitment at oxidative single-strand breaks
contribution of microhomology-mediated end joining (MMEJ) to DNA double-strand break repair in the genome is affected by radiation exposure via enhancement of the formation of MMEJ-proficient XRCC1 complex
Trp (show TBPL1 ELISA Kits) allele of codon 194 XRCC1 is a potential risk factor for breast cancer in Kurdish ethnicity. Furthermore, effect of this polymorphism on clinical and histological features of breast cancer was significant
This study suggests that the genetic variant of XRCC1 rs25487 may contribute to the etiology of ischemic stroke.
data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (show PARP1 ELISA Kits) as a therapeutic target in DNA strand break repair-defective disease
We have characterized the nuclear localization signal (NLS (show ALDH1A2 ELISA Kits)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (show OGG1 ELISA Kits), Neil1 (show NEIL1 ELISA Kits), Mutyh (show MUTYH ELISA Kits) and Xrcc1 in the brain of adult offspring.
In cells with DNA base damage, PAR (show AFG3L2 ELISA Kits) serves to recruit XRCC1 that in turn binds and recruits pol beta (show POLB ELISA Kits), the primary DNA polymerase (show POLB ELISA Kits) of the base excision repair pathway.
Lig4 (show LIG4 ELISA Kits) and XRCC1 double-deficient cells switch as efficiently as Lig4 (show LIG4 ELISA Kits)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination
findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (show LIG1 ELISA Kits)) may contribute more to A-EJ than previously considered
Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.
Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.
data reveal that the critical biological role of Lig3 (show LIG3 ELISA Kits) is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair
results establish a role for Lig3 (show LIG3 ELISA Kits) in mitochondria, but distinguish it from its interacting protein Xrcc1
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
X-ray repair complementing defective repair in Chinese hamster cells 1
, X-ray repair cross complementing protein 1
, DNA repair protein XRCC1-like
, DNA repair protein XRCC1
, X-ray repair cross-complementing protein 1
, X-ray-repair, complementing defective, repair in Chinese hamster
, x-ray repair cross-complementing group 1 protein