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This study evaluated the influence of genetic polymorphism GSTP1 (show GSTP1 Proteins) Ile105Val, GSTM1 (show GSTM1 Proteins) (null/non-null) and 2 XRCC1 polymorphisms (Arg194Trp and Arg399Gln) on the survival of ovarian carcinoma patients treated with chemotherapy. METHODS: 106 patients received treatment with a carboplatin-based or alternative chemotherapy. Polymorphisms were genotyped by pyrosequencing.
data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (show PARP1 Proteins) as a therapeutic target in DNA strand break repair-defective disease
Dominant alleles of RAD51 (show RAD51 Proteins), TP53 (show TP53 Proteins) and XRCC1 combined genotypes indicated a strong protective role against hereditary breast cancer.
XRCC1 is an HSP90 (show HSP90 Proteins) client protein that protects XRCC1 from proteasome-mediated degradation.
On stratification according to chemotherapy regimen administered; cisplatin/carboplatin + docetaxel was observed to increase survival for XRCC1 399 mutant genotype (AA) (HR 0.26, p = 0.05).
Chinese Han people with rs1799782 TT/CT genotype of XRCC1 gene may have increased risk of developing colorectal.
The investigation demonstrates that the XRCC1 Arg194Trp polymorphism constitutes a risk factor for thyroid carcinoma in Caucasian individuals (meta-analysis).
Polymorphism in XRCC1 and APE1 (show APEX1 Proteins) gene is associated with an increased risk of COPD (show ARCN1 Proteins).
the AA genotype and A allele of the XRCC1 Arg280His polymorphism are associated with an increased laryngeal cancer risk in a Chinese population.
The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (show CYP1A1 Proteins) (P < 0.001), rs1048943 in CYP1A1 (show CYP1A1 Proteins) (P < 0.001), rs1695 in GSTP1 (show GSTP1 Proteins) (P < 0.05), rs13181 in ERCC2 (show ERCC2 Proteins) (P < 0.001), and rs25487 in XRCC1 (P < 0.05); no such correlation existed in rs861539 in XRCC3 (show XRCC3 Proteins) (P > 0.05).
We have characterized the nuclear localization signal (NLS (show ALDH1A2 Proteins)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (show OGG1 Proteins), Neil1 (show NEIL1 Proteins), Mutyh (show MUTYH Proteins) and Xrcc1 in the brain of adult offspring.
In cells with DNA base damage, PAR (show AFG3L2 Proteins) serves to recruit XRCC1 that in turn binds and recruits pol beta (show POLB Proteins), the primary DNA polymerase (show POLB Proteins) of the base excision repair pathway.
Lig4 (show LIG4 Proteins) and XRCC1 double-deficient cells switch as efficiently as Lig4 (show LIG4 Proteins)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination
findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (show LIG1 Proteins)) may contribute more to A-EJ than previously considered
Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.
Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.
data reveal that the critical biological role of Lig3 (show LIG3 Proteins) is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair
results establish a role for Lig3 (show LIG3 Proteins) in mitochondria, but distinguish it from its interacting protein Xrcc1
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
X-ray repair complementing defective repair in Chinese hamster cells 1
, X-ray repair cross complementing protein 1
, DNA repair protein XRCC1-like
, DNA repair protein XRCC1
, X-ray repair cross-complementing protein 1
, X-ray-repair, complementing defective, repair in Chinese hamster
, x-ray repair cross-complementing group 1 protein