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Findings indicate a predictive role of X-ray repair cross complementing protein 1 (XRCC1) polymorphisms in clinical outcomes.
Data revealed the association of variant alleles of two polymorphisms, XRCC1 rs25487 and ERCC2 (show ERCC2 Proteins) rs1799793, with increased risk of breast cancer, providing evidence for their involvement in the etiology of breast cancer in ethnical Russians.
Arg194Trp SNP was associated with increased non-Hodgkin lymphoma (NHL) risk within the Asian population, and increased diffuse large B cell lymphoma (DLBCL) risk within the overall population; Arg399Gln SNP was associated with decreased risk for NHL and DLBCL; Arg280His SNP was not associated with NHL risk.[Meta-analysis]
XRCC1 Arg194Trp polymorphism may be associated with NSCLC risk, especially in smokers.
XRCC1 Arg399Gln gene polymorphism might influence the response to cisplatin-based chemotherapy and affect the clinical outcome of advanced non-small cell lung carcinoma.
XRCC1 Arg/Gln + Gln/Gln genotype increased the risk of multiple sclerosis.
was seen that the score was significantly higher in GG genotypes thereby corroborating the role of the polymorphism XRCC1 Arg399Gln
frequency of the minor allele corresponding to the Trp (show TBPL1 Proteins) allele of XRCC1Arg194Trp was higher in Asian populations than in African and Caucasian populations
the study indicates that the XRCC1 locus could be a potential candidate contributing to the pathogenesis of schizophrenia.
This meta-analysis suggested that the XRCC1 Arg194Trp polymorphism may be associated with efficacy of platinum-based chemotherapy.
We have characterized the nuclear localization signal (NLS (show ALDH1A2 Proteins)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (show OGG1 Proteins), Neil1 (show NEIL1 Proteins), Mutyh (show MUTYH Proteins) and Xrcc1 in the brain of adult offspring.
In cells with DNA base damage, PAR (show AFG3L2 Proteins) serves to recruit XRCC1 that in turn binds and recruits pol beta (show POLB Proteins), the primary DNA polymerase (show POLB Proteins) of the base excision repair pathway.
Lig4 (show LIG4 Proteins) and XRCC1 double-deficient cells switch as efficiently as Lig4 (show LIG4 Proteins)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination
findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (show LIG1 Proteins)) may contribute more to A-EJ than previously considered
Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.
Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.
data reveal that the critical biological role of Lig3 (show LIG3 Proteins) is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair
results establish a role for Lig3 (show LIG3 Proteins) in mitochondria, but distinguish it from its interacting protein Xrcc1
poly(ADP-ribose) polymerase-1 (show PARP1 Proteins) and XRCC1/DNA ligase III (show LIG3 Proteins) utilize an alternative route for DNA double-strand breaks rejoining
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
X-ray repair complementing defective repair in Chinese hamster cells 1
, X-ray repair cross complementing protein 1
, DNA repair protein XRCC1-like
, DNA repair protein XRCC1
, X-ray repair cross-complementing protein 1
, X-ray-repair, complementing defective, repair in Chinese hamster
, x-ray repair cross-complementing group 1 protein