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Browse our XRCC1 Proteins (XRCC1)

Full name:
X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 Proteins (XRCC1)
On www.antibodies-online.com are 6 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) Proteins from 4 different suppliers available. Additionally we are shipping XRCC1 Antibodies (116) and XRCC1 Kits (3) and many more products for this protein. A total of 132 XRCC1 products are currently listed.
Synonyms:
MGC80909, RCC, Xrcc-1, XRCC1
list all proteins Gene Name GeneID UniProt
XRCC1 7515 P18887
Mouse XRCC1 XRCC1 22594 Q60596
XRCC1 84495 Q9ESZ0

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XRCC1 Proteins (XRCC1) by Origin

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Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) interaction partners

  1. Findings indicate a predictive role of X-ray repair cross complementing protein 1 (XRCC1) polymorphisms in clinical outcomes.

  2. Data revealed the association of variant alleles of two polymorphisms, XRCC1 rs25487 and ERCC2 (show ERCC2 Proteins) rs1799793, with increased risk of breast cancer, providing evidence for their involvement in the etiology of breast cancer in ethnical Russians.

  3. Arg194Trp SNP was associated with increased non-Hodgkin lymphoma (NHL) risk within the Asian population, and increased diffuse large B cell lymphoma (DLBCL) risk within the overall population; Arg399Gln SNP was associated with decreased risk for NHL and DLBCL; Arg280His SNP was not associated with NHL risk.[Meta-analysis]

  4. XRCC1 Arg194Trp polymorphism may be associated with NSCLC risk, especially in smokers.

  5. XRCC1 Arg399Gln gene polymorphism might influence the response to cisplatin-based chemotherapy and affect the clinical outcome of advanced non-small cell lung carcinoma.

  6. XRCC1 Arg/Gln + Gln/Gln genotype increased the risk of multiple sclerosis.

  7. was seen that the score was significantly higher in GG genotypes thereby corroborating the role of the polymorphism XRCC1 Arg399Gln

  8. frequency of the minor allele corresponding to the Trp (show TBPL1 Proteins) allele of XRCC1Arg194Trp was higher in Asian populations than in African and Caucasian populations

  9. the study indicates that the XRCC1 locus could be a potential candidate contributing to the pathogenesis of schizophrenia.

  10. This meta-analysis suggested that the XRCC1 Arg194Trp polymorphism may be associated with efficacy of platinum-based chemotherapy.

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) interaction partners

  1. We have characterized the nuclear localization signal (NLS (show ALDH1A2 Proteins)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.

  2. Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (show OGG1 Proteins), Neil1 (show NEIL1 Proteins), Mutyh (show MUTYH Proteins) and Xrcc1 in the brain of adult offspring.

  3. In cells with DNA base damage, PAR (show AFG3L2 Proteins) serves to recruit XRCC1 that in turn binds and recruits pol beta (show POLB Proteins), the primary DNA polymerase (show POLB Proteins) of the base excision repair pathway.

  4. Lig4 (show LIG4 Proteins) and XRCC1 double-deficient cells switch as efficiently as Lig4 (show LIG4 Proteins)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination

  5. findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (show LIG1 Proteins)) may contribute more to A-EJ than previously considered

  6. Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.

  7. Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.

  8. data reveal that the critical biological role of Lig3 (show LIG3 Proteins) is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair

  9. results establish a role for Lig3 (show LIG3 Proteins) in mitochondria, but distinguish it from its interacting protein Xrcc1

  10. poly(ADP-ribose) polymerase-1 (show PARP1 Proteins) and XRCC1/DNA ligase III (show LIG3 Proteins) utilize an alternative route for DNA double-strand breaks rejoining

XRCC1 Protein Profile

Protein Summary

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Alternative names and synonyms associated with XRCC1

  • X-ray repair complementing defective repair in Chinese hamster cells 1 (xrcc1)
  • X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1)
  • X-ray repair complementing defective repair in Chinese hamster cells 1 (Xrcc1)
  • MGC80909 protein
  • RCC protein
  • Xrcc-1 protein
  • XRCC1 protein

Protein level used designations for XRCC1

X-ray repair complementing defective repair in Chinese hamster cells 1 , X-ray repair cross complementing protein 1 , DNA repair protein XRCC1-like , DNA repair protein XRCC1 , X-ray repair cross-complementing protein 1 , X-ray-repair, complementing defective, repair in Chinese hamster , x-ray repair cross-complementing group 1 protein

GENE ID SPECIES
446884 Xenopus laevis
456094 Pan troglodytes
476447 Canis lupus familiaris
616905 Bos taurus
711457 Macaca mulatta
100380033 Xenopus (Silurana) tropicalis
100390129 Callithrix jacchus
100458994 Pongo abelii
100469866 Ailuropoda melanoleuca
100519604 Sus scrofa
100580597 Nomascus leucogenys
7515 Homo sapiens
22594 Mus musculus
84495 Rattus norvegicus
100689414 Cricetulus griseus
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