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Study has shown that most rare XRCC2 missense variants have little effect on XRCC2 protein function and are unlikely to be associated with familial and early-onset breast cancer.
involvement of ZNF281 (show ZNF281 Proteins) in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
XRCC2 is shown to be the 20th Falconi anemia (FA) gene and is 2nd RAD51 (show RAD51 Proteins) paralog so identified. XRCC2 is required to maintain levels of other RAD51 (show RAD51 Proteins) paralogs that are normally present in XRCC2-RAD51B (show Rad51B Proteins)-C-D complex.
Polymorphism of XRCC2 gene is associated with Nasopharyngeal Carcinoma.
Results indicate that eight polymorphisms of XRCC1 (show XRCC1 Proteins), XRCC2, and XRCC3 (show XRCC3 Proteins) gene might be related to individual susceptibility to differentiated thyroid cancer (DTC) in Chinese population suggesting that XRCC1 (show XRCC1 Proteins) (rs25487, rs25489, rs1799782), XRCC2 (rs3218536), and XRCC3 (show XRCC3 Proteins) (rs1799794, rs56377012, rs1799796, rs861539) are novel genetic risk markers for DTC.
Results indicate that homologous recombination repair genes XRCC2 Arg188His and XRCC3 (show XRCC3 Proteins) Thr241Met polymorphisms may be positively associated with the incidence of ovarian carcinoma in the population of Polish women.
Suggest that XRCC2 is a useful predictive biomarker of preoperative radiotherapy treatment response in locally advanced rectal cancer patients.
The XRCC2 Arg188His polymorphism was associated with the risk of ovarian cancer. (Meta-analysis)
The aim of the present study was to evaluate the relationship between prostate cancer risk and the presence of single nucleotide polymorphisms in the genes involved in Homologous recombination repair, RAD51 (show RAD51 Proteins), RAD51B (show Rad51B Proteins), XRCC2 and XRCC3 (show XRCC3 Proteins).
In conclusion, XRCC2 Arg188His and XRCC3 (show XRCC3 Proteins) Thr241Met polymorphisms may be regarded as predictive factors of triple-negative breast cancer in female population.
Data show that XRCC2 and other homologous recombination proteins, including the key recombinase (show RAG1 Proteins) RAD51 (show RAD51 Proteins), co-localize with the centrosome, potentially to coordinate the deployment of a DNA damage response at vulnerable phases of the cell cycle.
These findings indicate that Xrcc2 haploinsufficiency reduces spontaneous tumor incidence on an Apc (show APC Proteins)(min/+) background but increases the tumorigenic response to radiation.
An important function of XRCC2 is to enhance the activity of RAD51 (show RAD51 Proteins), so that the loss of XRCC2 results in a severe delay in the early response of RAD51 (show RAD51 Proteins) to DNA damage.
Order-of-magnitude higher levels of chromosomal alterations are sustained in primary or immortal Xrcc2(-/-) embryonic fibroblasts.
the normal developmental programme is perturbed in Xrcc2-/- embryonic tissues, particularly during neurogenesis and somitogenesis
ATP hydrolysis by Rad51 (show RAD51 Proteins) is more important for some homologous recombination functions than it is for other aspects of DNA repair
Xrcc2 is important to preserve or restore replication forks during rapid clonal expansion of developing lymphocytes.
DNA replication licensing factor MCM2 (show MCM2 Proteins) and DNA mismatch repair (MMR (show MRC1 Proteins)) protein MSH2 (show MSH2 Proteins) were confirmed to be present in co-precipitations with MmXRCC2.
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.
X-ray repair cross complementing protein 2
, X-ray repair complementing defective repair in Chinese hamster cells 2
, DNA repair protein XRCC2
, X-ray repair cross-complementing protein 2
, recA/RAD51 family protein