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Browse our XRCC4 Proteins (XRCC4)

Full name:
X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 Proteins (XRCC4)
On www.antibodies-online.com are 6 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) Proteins from 4 different suppliers available. Additionally we are shipping XRCC4 Antibodies (106) and XRCC4 Kits (3) and many more products for this protein. A total of 124 XRCC4 products are currently listed.
Synonyms:
2310057B22Rik, AW413319, AW545101, homolog of human DNA ligase iv-binding protein XRCC4, MGC81443, zgc:73312
list all proteins Gene Name GeneID UniProt
XRCC4 7518 Q13426
Mouse XRCC4 XRCC4 108138 Q924T3
Rat XRCC4 XRCC4 309995  

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XRCC4 Proteins (XRCC4) by Origin

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More Proteins for XRCC4 Interaction Partners

Arabidopsis thaliana X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) interaction partners

  1. XRCC4 has a negative role in Agrobacterium T-DNA integration.

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) interaction partners

  1. Association between insertion/deletion polymorphism in intron 3 of XRCC4 and susceptibility to type I bipolar disorder

  2. For XRCC4 (rs1805377) polymorphism, no difference was found in distribution between the ESCC and control groups.

  3. using dual- and quadruple-trap optical tweezers combined with fluorescence microscopy, we show how human XRCC4, XLF (show NHEJ1 Proteins) and XRCC4-XLF (show NHEJ1 Proteins) complexes interact with DNA in real time

  4. The ends are then closely aligned, which requires XLF (show NHEJ1 Proteins), a non-catalytic function of XRCC4-LIG4 (show LIG4 Proteins), and DNA-PK activity

  5. Polymorphisms of XRCC4 are associated with susceptibility to Colorectal Cancer.

  6. FBXW7 (show FBXW7 Proteins) facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 in tumor cells.

  7. The XRCC4 -1394T/G polymorphism is associated with susceptibility to endometriosis in an Iranian population.

  8. Our results suggest that the XRCC4 rs2075685 polymorphism could influence the susceptibility to pancreatic cancer in a Chinese population.

  9. The TMPRSS2 (show TMPRSS2 Proteins)-ERG (show ERG Proteins) Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition

  10. Point mutations in XRCC4 is associated with microcephaly, short stature and genomic instability.

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) interaction partners

  1. Data show that combined deletion of X-ray repair cross-complementing protein 4 (Xrcc4) and tumor suppressor p53 (Trp53 (show TP53 Proteins)) predisposes B cells to lymphomagenesis.

  2. FBXW7 (show FBXW7 Proteins) facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 in tumor cells.

  3. The present results collectively indicated that Lys271, but not Lys210, of XRCC4 is required for the nuclear localization of XRCC4 and LIG4 (show LIG4 Proteins) and that the nuclear localizing ability is essential for DSB repair function of XRCC4.

  4. DNA-PK and ATM (show ATM Proteins) acts in parallel upstream of XRCC4, regulating through phosphorylation

  5. XRCC4 C-terminal point mutants, R325F and N326L, are functionally deficient in terms of cell survival after irradiation.

  6. These results establish that nonrecurrent CNVs can be, and frequently are, formed by mechanisms other than Xrcc4-dependent NHEJ.

  7. analysis of the association of radiation-induced XRCC4 with chromatin DNA, by biochemical fractionation

  8. conditional inactivation of the XRCC4 in nestin (show NES Proteins)-expressing neuronal progenitor cells, although leading to no obvious phenotype in a WT background, leads to early onset of neuronally differentiated medulloblastomas (MBs (show NEU2 Proteins)) in a p53 (show TP53 Proteins)-deficient background

  9. DNA-PK kinase activity results in disassembly of the Ku/DNA ligase IV (show LIG4 Proteins)/Xrcc4 complex

  10. Connection of XRCC4 and the nonhomologous end joining DNA repair pathway to immunoglobulin class switch recombination.

XRCC4 Protein Profile

Protein Summary

The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants.

Alternative names and synonyms associated with XRCC4

  • X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4)
  • X-ray repair complementing defective repair in Chinese hamster cells 4 (xrcc4)
  • DNA repair protein XRCC4-like protein (XRCC4)
  • X-ray repair complementing defective repair in Chinese hamster cells 4 (Xrcc4)
  • 2310057B22Rik protein
  • AW413319 protein
  • AW545101 protein
  • homolog of human DNA ligase iv-binding protein XRCC4 protein
  • MGC81443 protein
  • zgc:73312 protein

Protein level used designations for XRCC4

DNA repair protein XRCC4 , X-ray repair complementing defective repair in Chinese hamster cells 4 , DNA-repair protein XRCC4 , X-ray repair cross complementing protein 4 , X-ray repair cross-complementing protein 4 , X-ray repair, complementing defective, repair in Chinese hamster

GENE ID SPECIES
488923 Canis lupus familiaris
393759 Danio rerio
427325 Gallus gallus
443786 Xenopus laevis
471491 Pan troglodytes
100127743 Xenopus (Silurana) tropicalis
100173078 Pongo abelii
100603402 Nomascus leucogenys
821885 Arabidopsis thaliana
7518 Homo sapiens
613590 Bos taurus
108138 Mus musculus
309995 Rattus norvegicus
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