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Browse our anti-XRCC5 (XRCC5) Antibodies

Full name:
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) Antibodies (XRCC5)
On www.antibodies-online.com are 233 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) Antibodies from 28 different suppliers available. Additionally we are shipping XRCC5 Kits (29) and XRCC5 Proteins (3) and many more products for this protein. A total of 280 XRCC5 products are currently listed.
Synonyms:
AI314015, KARP-1, KARP1, KU80, Ku86, KUB2, Kup80, NFIV, XRCC5, xrcc5-a
list all antibodies Gene Name GeneID UniProt
XRCC5 22596 P27641
XRCC5 363247  
XRCC5 7520 P13010

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Most Popular Reactivities for anti-XRCC5 (XRCC5) Antibodies

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anti-Mouse (Murine) XRCC5 Antibodies:

anti-Rat (Rattus) XRCC5 Antibodies:

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Top referenced anti-XRCC5 Antibodies

  1. Human Monoclonal XRCC5 Primary Antibody for WB - ABIN393709 : Gomes, Silva, Azevedo, Manita, Gil, Ferreira, Limbert, Rueff, Gaspar: The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk. in Oncology reports 2010 (PubMed)
    Show all 5 references for ABIN393709

  2. Human Polyclonal XRCC5 Primary Antibody for EIA, IF - ABIN1449670 : Giffin, Gong, Schild-Poulter, Haché: Ku antigen-DNA conformation determines the activation of DNA-dependent protein kinase and DNA sequence-directed repression of mouse mammary tumor virus transcription. in Molecular and cellular biology 1999 (PubMed)
    Show all 3 references for ABIN1449670

  3. Human Monoclonal XRCC5 Primary Antibody for IF, WB - ABIN968493 : Kim, Kim, Han, Jeong, Chung, Kang, Li: Ku autoantigen affects the susceptibility to anticancer drugs. in Cancer research 1999 (PubMed)
    Show all 3 references for ABIN968493

  4. Human Polyclonal XRCC5 Primary Antibody for FACS, IF - ABIN655900 : Liu, Shete, Wang, El-Zein, Etzel, Liang, Armstrong, Tsavachidis, Gilbert, Aldape, Xing, Wu, Wei, Bondy: Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. in Carcinogenesis 2010 (PubMed)
    Show all 2 references for ABIN655900

  5. Human Polyclonal XRCC5 Primary Antibody for WB - ABIN374669 : Mayeur, Kung, Martinez, Izumiya, Chen, Kung: Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN374669

  6. Human Polyclonal XRCC5 Primary Antibody for EIA, WB - ABIN782978 : Zhang, Groenewold, Kegel: Observation of a microcrystalline gel in colloids with competing interactions. in Physical chemistry chemical physics : PCCP 2009 (PubMed)
    Show all 2 references for ABIN782978

  7. Human Monoclonal XRCC5 Primary Antibody for ICC, FACS - ABIN969463 : Nolens, Pignon, Koopmansch, Elmoualij, Zorzi, De Pauw, Winkler: Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines. in Breast cancer research : BCR 2010 (PubMed)
    Show all 2 references for ABIN969463

  8. Cow (Bovine) Polyclonal XRCC5 Primary Antibody for IHC, WB - ABIN2778271 : Sawchuk, Mansilla-Soto, Alarcon, Singha, Langen, Bianchi, Lees-Miller, Nussenzweig, Cortes: Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against XRCC5 Interaction Partners

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) interaction partners

  1. Ku (ku70 (show XRCC6 Antibodies)/ku80 heterodimer)roles in nonhomologous end joining and base excision repair pathways of DNA repair are overviewed.

  2. the downregulation of Ku80 and an impairment of repair activity in squamous cells, which are mediated by miR (show MLXIP Antibodies)-31.

  3. Inactivation of Ku80 and DNA-PKCS (show PRKDC Antibodies) causes reduced lifespan and bodyweight.

  4. A novel role for free Ku70 (show XRCC6 Antibodies) and free Ku80 in altering base excision repair.

  5. Ku80 plays an important role in base excision repair.

  6. Ku70/80 binds to DNA double strand breaks (DSB) in all cell cycle stages and is likely actively displaced from DSB ends to free the DNA ends for DNA end resection and thus homologous recombination to occur.

  7. There was a dose-dependent and time-dependent increase in Ku80 mRNA levels in nude mice that were inoculated with A549 cells and exposed to varying doses of irradiation.

  8. Ku70 (show XRCC6 Antibodies)/86 binds to the Apaf1 (show APAF1 Antibodies) promoter and represses its activity.

  9. Mobility of a major portion of Ku80 is not affected by DNA double strans breaks (DSBs) in order to find other DSBs in hamster cells.

  10. It was concluded that Ku86 deficiency accelerates high NaCl induced cellular senescence in cultured cells, C. elegans, and knockout mouse kidney.

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) interaction partners

  1. DNA methylation (show HELLS Antibodies) modification plays an important role to regulate the gene expression of XRCC5 and XRCC7 (show PRKDC Antibodies), from the results that the gene methylation level of the glioma group is higher than that of the normal group

  2. Data suggest that heat shock factor 1 (HSF1) interacts with both Ku autoantigens Ku70 and Ku86 to induce defective non-homologous end joining (NHEJ) repair activity and genomic instability.

  3. The present study showed that the XRCC5 locus might be a contributor to COPD susceptibility in the Chinese Han population.

  4. Depletion of Ku80 in the lens through acute change or a consequence of aging is likely to increase levels of DNA strand breaks, which could negatively influence physiological function and promote lens opacity (show MIP Antibodies)

  5. Data show that ubiquitin E3 ligase RNF138 (show RNF138 Antibodies) regulates Ku80 antigen ubiquitylation in response to DNA damage.

  6. Polymorphisms in the Variable Number of Tandem Repeats at the promoter region of the XRCC5 is associated with gastric cancer.

  7. retinoblastoma tumor suppressor protein (show TP53 Antibodies) variants disabled for the interaction with XRCC5 and XRCC6 (show XRCC6 Antibodies), including a cancer-associated variant, are unable to support canonical non-homologous end-joining despite being able to confer cell-cycle control

  8. Genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans generated independent evidence for the involvement of XRCC5 (Ku80) in alcohol dependence

  9. Our data indicated that Ku80 expression level associates with key clinicopathological features and is an independent predictor of the OS and the DFS (show FST Antibodies) in pT2N0M0 ESCC patients.

  10. Polymorphism in XRCC5 gene is associated with Systemic Lupus Erythematosus.

Xenopus laevis X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) interaction partners

  1. Double strand break (DSB)-induced ubiquitylation of Ku80 provides a mechanism to efficiently eliminate Ku from DNA for pre- and postrepair processes.

XRCC5 Antigen Profile

Antigen Summary

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Alternative names and synonyms associated with XRCC5

  • X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) (XRCC5) antibody
  • X-ray repair complementing defective repair in Chinese hamster cells 5 (Xrcc5) antibody
  • X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) (xrcc5) antibody
  • X-ray repair cross-complementing protein 5-like (LOC531945) antibody
  • AI314015 antibody
  • KARP-1 antibody
  • KARP1 antibody
  • KU80 antibody
  • Ku86 antibody
  • KUB2 antibody
  • Kup80 antibody
  • NFIV antibody
  • XRCC5 antibody
  • xrcc5-a antibody

Protein level used designations for XRCC5

Ku autoantigen , X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) , X-ray repair protein , X-ray repair cross-complementing protein 5 , X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) , ATP-dependent DNA helicase II , ATP-dependent DNA helicase 2 subunit 2-like , x-ray repair cross-complementing protein 5-like , ATP-dependent DNA helicase 2 subunit 2 , ATP-dependent DNA helicase II 80 kDa subunit , CTC box-binding factor 85 kDa subunit , CTC85 , CTCBF , DNA repair protein XRCC5 , Ku p80 , ku autoantigen protein p86 homolog , nuclear factor IV , Ku autoantigen, 80kD) , X-ray repair cross complementation (double-strand-break rejoining , X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD) , 86 kDa subunit of Ku antigen , Ku autoantigen, 80kDa , Ku86 autoantigen related protein 1 , TLAA , lupus Ku autoantigen protein p86 , thyroid-lupus autoantigen , X-ray repair complementing defective repair in Chinese hamster cells 5

GENE ID SPECIES
449614 Pan troglodytes
478902 Canis lupus familiaris
574279 Macaca mulatta
100173343 Pongo abelii
100347656 Oryctolagus cuniculus
100409742 Callithrix jacchus
100484832 Ailuropoda melanoleuca
100514133 Sus scrofa
100603811 Nomascus leucogenys
22596 Mus musculus
363247 Rattus norvegicus
7520 Homo sapiens
394397 Xenopus laevis
424222 Gallus gallus
531945 Bos taurus
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