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Data show the structure of the Cdc45/Mcm2-7 (show MCM2 ELISA Kits)/Psf1 GINS (CMG (show CASK ELISA Kits)) helicase (show DNA2 ELISA Kits) in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.
CDC-48/p97 (show vcp ELISA Kits) coordinates CDT-1 (show CDT1 ELISA Kits) degradation with GINS chromatin dissociation to ensure faithful DNA replication
PSF1 (show TAP1 ELISA Kits) mRNA expression was an independent factor associated with prognosis of colorectal cancer.
These results suggest that PSF1 (show TAP1 ELISA Kits) over-expression is specifically involved in breast cancer cell growth.
Findings implicate PSF1 (show TAP1 ELISA Kits) in tumorigenesis and offer initial evidence of its potential as a theranostic target.
expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha (show ESR1 ELISA Kits), and PSF3 (show GINS3 ELISA Kits) acts as a gene responsive to transcription factor E2F1 (show E2F1 ELISA Kits)
the C-terminal domain of Psf1 (show TAP1 ELISA Kits) does not contribute to the stability of the GINS complex but is crucial for chromatin binding and replication activity
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4\; MIM 610611), Psf1, Psf2 (GINS2\; MIM 610609), and Psf3 (GINS3\; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005
DNA replication complex GINS protein PSF1
, DNA replication complex GINS protein psf1
, GINS complex subunit 1
, GINS complex subunit 1 (Psf1 homolog)
, partner of sld five-1
, GINS complex subunit 4 (Sld5 homolog)
, potential GINS DNA replication initiation complex subunit