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Data show the structure of the Cdc45/Mcm2-7/Psf1 GINS (CMG) helicase in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.
CDC-48/p97 (show vcp Proteins) coordinates CDT-1 (show CDT1 Proteins) degradation with GINS chromatin dissociation to ensure faithful DNA replication
Autosomal recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine (and postnatal) growth retardation, chronic neutropenia, and NK cell deficiency.
PSF1 (show TAP1 Proteins) mRNA expression was an independent factor associated with prognosis of colorectal cancer.
These results suggest that PSF1 (show TAP1 Proteins) over-expression is specifically involved in breast cancer cell growth.
Findings implicate PSF1 (show TAP1 Proteins) in tumorigenesis and offer initial evidence of its potential as a theranostic target.
expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha (show ESR1 Proteins), and PSF3 (show GINS3 Proteins) acts as a gene responsive to transcription factor E2F1 (show E2F1 Proteins)
the C-terminal domain of Psf1 (show TAP1 Proteins) does not contribute to the stability of the GINS complex but is crucial for chromatin binding and replication activity
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4\; MIM 610611), Psf1, Psf2 (GINS2\; MIM 610609), and Psf3 (GINS3\; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005
DNA replication complex GINS protein PSF1
, DNA replication complex GINS protein psf1
, GINS complex subunit 1
, GINS complex subunit 1 (Psf1 homolog)
, partner of sld five-1
, GINS complex subunit 4 (Sld5 homolog)
, potential GINS DNA replication initiation complex subunit