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the findings of the current study provide compelling genetic evidence that FOXA2 is a pathogenic driver gene in the etiology of primary uterine cancers, including uterine carcinosarcomas and carcinomas.
A molecular mechanism by which Estradiol antagonizes GR-dependent induction of specific genes by preventing the recruitment of the pioneer factors FOXA1 (show FOXA1 Proteins) and FOXA2 in a physiologically relevant model.
Physical and functional interactions between LXRalpha (show NR1H3 Proteins) and FOXA2 were established in vitro and ex vivo.
SIRT1 (show SIRT1 Proteins) directly interacts with and deacetylates Foxa2 to inhibit its transcriptional activity on expression of genes involved in bile acids synthesis and transport.
Iotansulin decreased LPL (show LCP1 Proteins) mRNA levels in HepG2 cells and this was associated with phosphorylation of AKT (show AKT1 Proteins) and nuclear export of FOXA2.
findings provide the structural basis for FOXA2 protein binding to a consensus forkhead site and elucidate how members of the forkhead protein (show FOXO4 Proteins) family bind different DNA sites.
Low FOXA2 expression is associated with metastasis of gastric cancer.
FOXA2 identified as a novel tumor suppressor in pancreatic cancer. It is regulated directly by miR (show MLXIP Proteins)-199a.
This study used combined immunohistochemical staining for a marker of hepatic commitment and specification (FOXA2 [Forkhead box A2]), hepatocyte maturation (Albumin (show ALB Proteins) and HepPar1), and features of bile ducts (CK19 (show KRT19 Proteins) [cytokeratin 19 (show KRT19 Proteins)]) to identify lineages of stem cells differentiating toward the hepatocytic or bile ductular compartments of end-stage cirrhotic human liver.
Foxa2, a novel protein partner of the tumour suppressor menin, is deregulated in mouse and human MEN1 glucagonomas.
in FoxA2-FoxA3 (show FOXA3 Proteins) double morphants, precursors of axial tissues are correctly induced at early gastrula stage, but their dorsal midline identity is not maintained during development
Foxa2 is required for induction and/or patterning of several distinct cell types in the ventral CNS.
Together SMAD3 (show SMAD3 Proteins) and ZIC2 regulate FOXA2 transcription in cultured cells and Zic2 also controls the foxA2 expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 loss-of-function precipitates Holoprosencephaly (HPE).
HNF3beta target genes function to limit the extent of mesoderm formation in the Xenopus gastrula.
Forkhead box A2regulates biliary heterogeneity during cholestatic liver injury in mouse models.
our study demonstrates that Foxa2 is required in both alpha and beta cells for maintaining appropriate glucagon (show GCG Proteins) and insulin (show INS Proteins) levels and for keeping glucose homeostasis.
Loss of Interdependent Binding by the FoxO1 (show FOXO1 Proteins) and FoxA1 (show FOXA1 Proteins)/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin (show INS Proteins)-sensitive Genes.
FoxA1 (show FOXA1 Proteins), FoxA2, and LIPG (show LIPG Proteins) control the uptake of extracellular lipids for breast cancer growth.
The authors show herein that Nurr1 (show NR4A2 Proteins) and Foxa2 interact to protect midbrain dopaminergic neurons against various toxic insults, but their expression is lost during aging and degenerative processes.
Authors identified thousands of enhancers that are bound by the master regulators HNF4A (show HNF4A Proteins) and FOXA2 in a differentiation-dependent manner, subject to chromatin remodeling, and associated with differentially expressed target genes.
this study demonstrates that SIRT1 (show SIRT1 Proteins) controls the acetylation level of FOXA2 in a nutrient-dependent manner and in times of nutrient shortage the interaction between SIRT1 (show SIRT1 Proteins) and FOXA2 is reduced.
Hh signaling upregulated FOXA2, which induced expression of MUC2 (show MUC2 Proteins), an intestinal mucin (show SLC13A2 Proteins) found in Barrett's esophagus, and the MUC2 (show MUC2 Proteins)-processing protein AGR2 (show AGR2 Proteins)
through interactions with FoxA2, Arx positively regulates Shh expression in the floor plate, and Shh signaling in turn activates Nkx2.2, which suppresses Arx expression.
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.
fork head transcription factor FoxA2
, forkhead box protein A2
, forkhead box A2
, hepatic nuclear factor-3-beta
, hepatocyte nuclear factor 3, beta
, hepatocyte nuclear factor 3-beta
, transcription factor 3B
, axial protein
, HNF3-beta homolog A
, Hepatocyte nuclear factor 3-beta homolog A
, fork head domain-related protein 3
, forkhead box protein A2-A
, hepatocyte nuclear factor 3 beta
, hepatocyte nuclear factor 3 beta (winged helix transcription factor)
, hepatocyte nuclear factor-3 beta
, hepatocyte nuclear factor-3beta
, transcription factor Foxa2