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SCL (show TAL1 Proteins)-LMO1 upregulated a stem cell gene signature in DN3 thymocytes.
Loss of Lmo1 repression may be one of the causes accounting for the phenotypic differences identified between the Arx((GCG)7)and Arx(432-455dup24) mouse models.
SCL (show TAL1 Proteins), LMO1, and Notch1 (show NOTCH1 Proteins) gain of function, together with an active pre-T-cell antigen receptor (show PTCRA Proteins), might represent the minimum set of complementing events for the transformation of susceptible thymocytes into cancer cells
Results suggest that all four members of the LIM (show PDLIM5 Proteins)-only family -- LMO1, 2, 3, and 4 -- are important regulators of distinct developmental pathways.
Lmo1 takes part in a Hox (show MSH2 Proteins) paralogue 2-dependent network regulating anteroposterior and dorsoventral hindbrain patterning
LMO1 is an important oncogene (show RAB1A Proteins) that promotes neuroblastoma (show ARHGEF16 Proteins) initiation, progression, and widespread metastatic dissemination.
LMO1 appears to be a coactivator of AR involved in the progression of prostate cancer
data suggest that genetic variants in LMO1 are associated with increased NB risk in Chinese children.
a polymorphism within a super-enhancer element in the first intron of LMO1 influences neuroblastoma (show ARHGEF16 Proteins) susceptibility through differential GATA (show QRSL1 Proteins) transcription factor binding and direct modulation of LMO1 expression in cis (show CISH Proteins)
LMO1 is a commonly activated tumor promoter that activates AKT (show AKT1 Proteins) signaling in non-small cell lung cancer.
LMO1 is a commonly activated tumor promoter that activates AKT (show AKT1 Proteins) signaling in colorectal cancer and a new predictive marker for targeted therapy.
results show that LMO1 is poised for expression in normal progenitors, where activation of SCL/TAL1 (show TAL1 Proteins) together with a breakdown of epigenetic repression of LMO1 regulatory elements
genetic variants within LMO1 are associated with acute lymphoblastic leukemia and identify this gene as a strong candidate for precursor B-cell leukemogenesis.
data show that common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma (show ARHGEF16 Proteins), but also may influence the likelihood of further somatic alterations at this locus, leading to malignant progression
60% of transgenic mice that overexpressed both OLIG2 (show OLIG2 Proteins) and LMO1 developed pre-T lymphoblastic lymphoma/leukemia with large thymic tumor masses.
This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions\; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described.
LIM domain only 1 (rhombotin 1)
, LIM domain only protein 1
, LIM only 1
, T-cell translocation protein 1
, cysteine-rich protein TTG-1
, LIM domain only protein 3
, LIM domain only 3
, neuronal-specific transcription factor DAT1
, dopamine-inducible LIM-domain transcription factor DAT1
, T-cell translocation gene 1
, rhombotin 1