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Browse our anti-SOX2 (SOX2) Antibodies

Full name:
anti-SRY (Sex Determining Region Y)-Box 2 Antibodies (SOX2)
On www.antibodies-online.com are 456 SRY (Sex Determining Region Y)-Box 2 (SOX2) Antibodies from 38 different suppliers available. Additionally we are shipping SOX2 Proteins (36) and SOX2 Kits (14) and many more products for this protein. A total of 521 SOX2 products are currently listed.
Synonyms:
anop3, cb236, lcc, mcops3, Qscn6, Qsox, RGD1565646, rSOx, sox-2, SRY-box2, wu:fb83g04, wu:fc14d07, Xsox-2, ysb, zgc:65860, zgc:77389

Most Popular Reactivities for anti-SOX2 (SOX2) Antibodies

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anti-Rat (Rattus) SOX2 Antibodies:

anti-Human SOX2 Antibodies:

anti-Mouse (Murine) SOX2 Antibodies:

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Top referenced anti-SOX2 Antibodies

  1. Human Polyclonal SOX2 Primary Antibody for EIA, FACS - ABIN4620427 : Reményi, Lins, Nissen, Reinbold, Schöler, Wilmanns: Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. in Genes & development 2003 (PubMed)
    Show all 5 references for ABIN4620427

  2. Human Polyclonal SOX2 Primary Antibody for DB - ABIN390034 : Wiebe, Nowling, Rizzino: Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN390034

  3. Human Polyclonal SOX2 Primary Antibody for DB, IF - ABIN650887 : Gen, Yasui, Zen, Zen, Dohi, Endo, Tsuji, Wakabayashi, Itoh, Naito, Taniwaki, Nakanuma, Okanoue, Yoshikawa: SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma. in Cancer genetics and cytogenetics 2010 (PubMed)
    Show all 3 references for ABIN650887

  4. Human Polyclonal SOX2 Primary Antibody for WB - ABIN783320 : Yuan, Corbi, Basilico, Dailey: Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. in Genes & development 1995 (PubMed)
    Show all 3 references for ABIN783320

  5. Human Polyclonal SOX2 Primary Antibody for DB - ABIN650879 : Ji, Zheng: Expression of Sox2 in human cervical carcinogenesis. in Human pathology 2010 (PubMed)
    Show all 3 references for ABIN650879

  6. Chicken Polyclonal SOX2 Primary Antibody for IHC, WB - ABIN2777428 : Wang, Liang, Yi, Zhang: Novel SOX2 mutation associated with ocular coloboma in a Chinese family. in Archives of ophthalmology 2008 (PubMed)
    Show all 2 references for ABIN2777428

  7. Human Polyclonal SOX2 Primary Antibody for DB - ABIN650873 : Laga, Lai, Zhan, Huang, Velazquez, Yang, Hsu, Murphy: Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology. in The American journal of pathology 2010 (PubMed)
    Show all 2 references for ABIN650873

  8. Chicken Polyclonal SOX2 Primary Antibody for WB - ABIN2780467 : Lei, Liu, Sodja, LeBlanc, Ribecco-Lutkiewicz, Smith, Charlebois, Walker, Sikorska: S/MAR-binding properties of Sox2 and its involvement in apoptosis of human NT2 neural precursors. in Cell death and differentiation 2005 (PubMed)

More Antibodies against SOX2 Interaction Partners

Human SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. High SOX2 Expression is associated with Breast Cancer.

  2. This review reveled that the role of SOX2 which is the master regulator of pluripotency and maintenance of tumor stem cell properties in glioblastoma and medulloblastoma.

  3. cyclin D1 (show CCND1 Antibodies) is a direct target of transcription factor SOX2 in human lung squamous cell carcinoma cells.

  4. High SOX2 expression is associated with glioma.

  5. Progression of cervical squamous neoplasia may involve cyclical alterations in SOX2 activity

  6. Overexpression of Sox2 that is correlated with vascular invasion and poor differentiation suggests poor outcomes of patients with digestive tract cancers. (Meta-analysis)

  7. SOX2 role in epithelial-mesenchymal transition and invasion of hepatocellular carcinoma.MiR-638 directly inhibits SOX2 expression by interacting with its 3'-UTR (show UTS2R Antibodies).

  8. Oct4 (show POU5F1 Antibodies)+Sox2+ cells may be reprogrammed cancer stem cells inducing oral carcinogenesis.

  9. At the subcellular level, SOX2 inhibited the GC cell migration and invasion by upregulating p21 (show CDKN1A Antibodies) expression. Moreover, SOX2 was determined to associate with the nuclear p21 (show CDKN1A Antibodies) expression. GC patients with high SOX2 and nuclear p21 (show CDKN1A Antibodies) expression had synergistically less lymph node metastasis and the better overall survival

  10. SOX2 expression correlates with gastric and intestinal differentiation in Barrett's esophagus towards adenocarcinoma.

Xenopus laevis SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.

  2. Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.

  3. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  4. Suggest that SOX2 directly upregulates FGF8 (show FGF8 Antibodies) gene expression in the early embryonic development of Xenopus.

  5. Continuous expression of Sox1 (show SOX1 Antibodies) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.

  6. direct interaction and interdependence between the Otx2 (show OTX2 Antibodies) and Sox2 proteins coordinate Rax (show RAX Antibodies) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.

  7. Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2

  8. A directional Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.

Pig (Porcine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Sox2 has a role in pluripotency in pig embryos

  2. Overexpression of Sox2 or Oct4 (show POU5F1 Antibodies) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Antibodies) results in higher proliferation and differentiation compared to controls.

  3. cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level

Cow (Bovine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 Antibodies).

  2. analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos

  3. Sox2 displayed relatively the same methylation levels between sperm and oocytes

Mouse (Murine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Study provides evidence that Sox2 expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 (show ATOH1 Antibodies) expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1 (show ATOH1 Antibodies).

  2. Data show that the reprogramming factors OCT4 (show POU5F1 Antibodies), SOX2, KLF4 (show KLF4 Antibodies), and MYC (show MYC Antibodies) (OSKM) drive cells along two distinct and parallel pathways, one pluripotent and one endodermal.

  3. SOX2 is a regulatory factor of Prop1 (show PROP1 Antibodies) expression

  4. our study provides valuable information on the molecular interactions between OSKM(Oct4 (show POU5F1 Antibodies), Sox2, Klf4 (show KLF4 Antibodies), and Myc (show MYC Antibodies)) and cofactors and molecular mechanisms for the functional importance of Set1a (show SETD1A Antibodies) in ESCs (show NR2E3 Antibodies) and early development

  5. These findings show that SOX2 activity is modulated by O-acetylglusosamine, and provide a novel regulatory mechanism for this crucial pluripotency transcription factor.

  6. Besides its role in fine-tuning the precise level of Sox2, Ube2s (show UBE2S Antibodies) reinforces the self-renewing and pluripotent state of embryonic stem cells.

  7. SOX2(+) stem cells initially play a significant role in contributing to postnatal pituitary gland expansion by self-renewal and differentiating into distinct lineages in the immediate postnatal period.

  8. Using photo-activatable Fluorescence Correlation Spectroscopy to quantify transcription factor-DNA binding in single cells of developing mouse embryos, study found that Sox2 long-lived binding varies between blastomeres and is regulated by H3R26 methylation.

  9. Our findings clarify that mutated SOX2-positive SCs (show TWIST1 Antibodies) can underlie the pathogenesis of odontoma, through a mechanism of induction similar to embryonic odontogenesis.

  10. The REST-miR (show MLXIP Antibodies)-21-Sox2 axis connects REST to the core nuclear pluripotency regulators in E14Tg2a.4 mESCs cultured in the absence of feeder cells.

Zebrafish SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.

  2. a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury

  3. Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.

  4. significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.

  5. Knockdown of the four B1 sox (show PIPOX Antibodies) genes sox2/3/19a/19b resulted in severe developmental abnormalities.

  6. sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration

  7. shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs

  8. zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line

  9. Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters.

SOX2 Antigen Profile

Antigen Summary

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Alternative names and synonyms associated with SOX2

  • SRY (sex determining region Y)-box 2 (LOC100231711) antibody
  • quiescin Q6 sulfhydryl oxidase 1 (Qsox1) antibody
  • SRY (sex determining region Y)-box 2 (SOX2) antibody
  • SRY (sex determining region Y)-box 2 (Sox2) antibody
  • SRY (sex determining region Y)-box 2 (sox2) antibody
  • SRY-box containing gene 2 (Sox2) antibody
  • SRY-box containing gene 2 (sox2) antibody
  • anop3 antibody
  • cb236 antibody
  • lcc antibody
  • mcops3 antibody
  • Qscn6 antibody
  • Qsox antibody
  • RGD1565646 antibody
  • rSOx antibody
  • sox-2 antibody
  • SRY-box2 antibody
  • wu:fb83g04 antibody
  • wu:fc14d07 antibody
  • Xsox-2 antibody
  • ysb antibody
  • zgc:65860 antibody
  • zgc:77389 antibody

Protein level used designations for SOX2

SRY (sex determining region Y)-box 2 , FAD-dependent sulfhydryl oxidase-2 , rQSOX , sulfhydryl oxidase 1 , SRY-related HMG-box gene 2 , transcription factor SOX-2 , transcription factor SOX2 , SRY-box containing gene 2 , Sox2 transcription factor , cSox2 , delta EF2a , XSox2 , XlSOX-2 , sex-determining region Y-box 2 , transcription factor Sox-2 , SRY-box 2 , SRY-related HMG-box 2 , sex determining region Y-box 2 , soxp

GENE ID SPECIES
100231711 Taeniopygia guttata
84491 Rattus norvegicus
6657 Homo sapiens
499593 Rattus norvegicus
396105 Gallus gallus
488092 Canis lupus familiaris
398000 Xenopus laevis
407739 Sus scrofa
784383 Bos taurus
101110563 Ovis aries
707039 Macaca mulatta
460869 Pan troglodytes
100379629 Felis catus
100714747 Cavia porcellus
20674 Mus musculus
378723 Danio rerio
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