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This study demonstrated a cell-autonomous requirement for ADCY8 in retinal neurons for normal midline crossing. These findings are the first to show that ADCY8 is required for axonal pathfinding before axons reach their targets.
Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety.
Dysregulation of a survival pathway in adenylyl cyclase 1 (show ADCY1 ELISA Kits) and 8 knockout mice was identified following early-life ethanol exposure.
Study shows that AC8 is involved in epileptogenesis, and may serve as a potential target for the treatment of epilepsy
ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin (show INS ELISA Kits) secretion.
these results support a complex role of cAMP signaling pathways confirming the involvement of AC8 in the modulation of stress responses.
ACVIII gene is regulated by CREB (show CREB1 ELISA Kits) in vitro and in vivo and this regulation may contribute to CREB (show CREB1 ELISA Kits)-dependent neural plasticity
AC8 accumulates in puncta of dendrites and axons in hippocampal neurons and localizes with synaptic marker proteins indicating synaptic and nonsynaptic cAMP signals generated by different Ca2 (show CA2 ELISA Kits)+-stimulated adenylyl cyclases are required for mossy fiber LTP (show SCP2 ELISA Kits)
AC8 expression is initially restricted to the epithalamus, the hypothalamus, the superior colliculus, the cerebellar anlage the proliferative zone of the rhombic lip, and the spinal cord.
AC8 protein levels were abundant during development, with diffuse and increasing expression in the hippocampus that intensified in the CA1 (show CA1 ELISA Kits)/CA2 (show CA2 ELISA Kits) region by adulthood. in the presynaptic active zone and extrasynaptic fractions.
data suggest that AC1/AC8 are crucial activators of cell survival signaling pathways acutely following ethanol exposure and represent molecular factors that may directly modulate the severity of symptoms associated with Fetal Alcohol Syndrome
Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9 (show KCNK9 ELISA Kits)) and subcutaneous (MLLT10 (show MLLT10 ELISA Kits)/DNAJC1 (show DNAJC1 ELISA Kits)/EBLN1 (show EBLN2 ELISA Kits)) fat, and confirmed a locus (THNSL2 (show THNSL2 ELISA Kits)) previously reported to be associated with abdominal fat in women
Results show that promoter hypermethylation of ADCY8, CDH8, and ZNF582 are correlated with high-grade squamous intraepithelial lesion.
ADCY8 is integral for long-term potentiation and synaptic plasticity and is implicated in fear-related learning and memory.
Polymorphisms ADCY8 are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression.
The adenylate cyclase 8 plays a major role in cAMP production.
Orai1 (show ORAI1 ELISA Kits) and AC8 binding mediates dynamic interplay between Ca2 (show CA2 ELISA Kits)+ and cAMP signaling
cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R (show GLP1R ELISA Kits).
Ca2 (show CA2 ELISA Kits)+ entry increase was accompanied by red cell aggregation rise, while adenylyl cyclase-cAMP system stimulation led to red cell deformability increase and its aggregation lowered.
Data reveal that an association of the Ca(2 (show CA2 ELISA Kits)+)-stimulable AC8 with AKAP79 (show AKAP5 ELISA Kits)/150 that limits the sensitivity of AC8 to intracellular Ca(2 (show CA2 ELISA Kits)+) events.
CaM is collapsed around the adenylyl cyclase 8 peptides that binds to CaM in an antiparallel orientation.
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase
adenylate cyclase 8 (brain)
, adenylate cyclase type VIII
, adenylate cyclase type 8
, adenylate cyclase type 8-like
, ATP pyrophosphate-lyase 8
, adenylyl cyclase 8
, ca(2+)/calmodulin-activated adenylyl cyclase
, adenylyl cyclase-8, brain
, type VIII adenylyl cyclase
, adenylate cyclase 3