Browse our ADCY8 Proteins (ADCY8)

Full name:
Adenylate Cyclase 8 (Brain) Proteins (ADCY8)
On are 11 Adenylate Cyclase 8 (Brain) (ADCY8) Proteins from 4 different suppliers available. Additionally we are shipping ADCY8 Antibodies (44) and many more products for this protein. A total of 60 ADCY8 products are currently listed.
Ac8, ADCY3, AW060868, HBAC1, MGC121231, si:ch211-220f13.4
list all proteins Gene Name GeneID UniProt
ADCY8 11514 P97490
ADCY8 114 P40145
ADCY8 29241 P40146

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ADCY8 Proteins (ADCY8) by Origin

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More Proteins for ADCY8 Interaction Partners

Zebrafish Adenylate Cyclase 8 (Brain) (ADCY8) interaction partners

  1. This study demonstrated a cell-autonomous requirement for ADCY8 in retinal neurons for normal midline crossing. These findings are the first to show that ADCY8 is required for axonal pathfinding before axons reach their targets.

Mouse (Murine) Adenylate Cyclase 8 (Brain) (ADCY8) interaction partners

  1. Dysregulation of a survival pathway in adenylyl cyclase 1 (show ADCY1 Proteins) and 8 knockout mice was identified following early-life ethanol exposure.

  2. Study shows that AC8 is involved in epileptogenesis, and may serve as a potential target for the treatment of epilepsy

  3. ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin (show INS Proteins) secretion.

  4. these results support a complex role of cAMP signaling pathways confirming the involvement of AC8 in the modulation of stress responses.

  5. ACVIII gene is regulated by CREB (show CREB1 Proteins) in vitro and in vivo and this regulation may contribute to CREB (show CREB1 Proteins)-dependent neural plasticity

  6. AC8 accumulates in puncta of dendrites and axons in hippocampal neurons and localizes with synaptic marker proteins indicating synaptic and nonsynaptic cAMP signals generated by different Ca2 (show CA2 Proteins)+-stimulated adenylyl cyclases are required for mossy fiber LTP (show SCP2 Proteins)

  7. AC8 expression is initially restricted to the epithalamus, the hypothalamus, the superior colliculus, the cerebellar anlage the proliferative zone of the rhombic lip, and the spinal cord.

  8. AC8 protein levels were abundant during development, with diffuse and increasing expression in the hippocampus that intensified in the CA1 (show CA1 Proteins)/CA2 (show CA2 Proteins) region by adulthood. in the presynaptic active zone and extrasynaptic fractions.

  9. data suggest that AC1 (show HRASLS Proteins)/AC8 are crucial activators of cell survival signaling pathways acutely following ethanol exposure and represent molecular factors that may directly modulate the severity of symptoms associated with Fetal Alcohol Syndrome

Human Adenylate Cyclase 8 (Brain) (ADCY8) interaction partners

  1. Our results provide evidence for new loci influencing abdominal visceral (BBS9 (show BBS9 Proteins), ADCY8, KCNK9 (show KCNK9 Proteins)) and subcutaneous (MLLT10 (show MLLT10 Proteins)/DNAJC1 (show DNAJC1 Proteins)/EBLN1 (show EBLN2 Proteins)) fat, and confirmed a locus (THNSL2 (show THNSL2 Proteins)) previously reported to be associated with abdominal fat in women

  2. Results show that promoter hypermethylation of ADCY8, CDH8 (show CDH8 Proteins), and ZNF582 (show ZNF582 Proteins) are correlated with high-grade squamous intraepithelial lesion.

  3. ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin (show INS Proteins) secretion.

  4. ADCY8 is integral for long-term potentiation and synaptic plasticity and is implicated in fear-related learning and memory.

  5. Polymorphisms ADCY8 are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression.

  6. The adenylate cyclase 8 plays a major role in cAMP production.

  7. Orai1 and AC8 binding mediates dynamic interplay between Ca2 (show CA2 Proteins)+ and cAMP signaling

  8. cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R (show GLP1R Proteins).

  9. Ca2 (show CA2 Proteins)+ entry increase was accompanied by red cell aggregation rise, while adenylyl cyclase-cAMP system stimulation led to red cell deformability increase and its aggregation lowered.

  10. Data reveal that an association of the Ca(2 (show CA2 Proteins)+)-stimulable AC8 with AKAP79 (show AKAP5 Proteins)/150 that limits the sensitivity of AC8 to intracellular Ca(2 (show CA2 Proteins)+) events.

Cow (Bovine) Adenylate Cyclase 8 (Brain) (ADCY8) interaction partners

  1. CaM (show KRIT1 Proteins) is collapsed around the adenylyl cyclase 8 peptides that binds to CaM (show KRIT1 Proteins) in an antiparallel orientation.

ADCY8 Protein Profile

Protein Summary

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase

Alternative names and synonyms associated with ADCY8

  • adenylate cyclase 8 (brain) (adcy8)
  • adenylate cyclase 8 (brain) (ADCY8)
  • adenylate cyclase 8 (Adcy8)
  • adenylate cyclase 8 (brain) (Adcy8)
  • Ac8 protein
  • ADCY3 protein
  • AW060868 protein
  • HBAC1 protein
  • MGC121231 protein
  • si:ch211-220f13.4 protein

Protein level used designations for ADCY8

adenylate cyclase 8 (brain) , adenylate cyclase type VIII , ADCY_3 , adenylate cyclase type 8 , adenylate cyclase type 8-like , ATP pyrophosphate-lyase 8 , adenylyl cyclase 8 , ca(2+)/calmodulin-activated adenylyl cyclase , adenylyl cyclase-8, brain , type VIII adenylyl cyclase , adenylate cyclase 3

414729 Xenopus laevis
420328 Gallus gallus
464400 Pan troglodytes
695792 Macaca mulatta
100026554 Monodelphis domestica
100057796 Equus caballus
100124758 Xenopus (Silurana) tropicalis
100148976 Danio rerio
100337882 Oryctolagus cuniculus
100461383 Pongo abelii
100474121 Ailuropoda melanoleuca
11514 Mus musculus
114 Homo sapiens
29241 Rattus norvegicus
482045 Canis lupus familiaris
535017 Bos taurus
100514402 Sus scrofa
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