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anti-Human Adenylate Cyclase 2 Antibodies:
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In patients receiving capecitabine monotherapy, rs4702484, located in ADCY2 and close to MTRR (show MTRR Antibodies), was associated with slightly reduced PFS for homozygous wild-type patients (CC 6.2 vs. CT 8.0 months; P=0.018).
Our present study defines an AC2 cAMP signaling compartment that specifically regulates IL-6 (show IL6 Antibodies) expression in bronchial smooth muscle cells.
AKAP79 (show AKAP5 Antibodies), PKC (show PRRT2 Antibodies), PKA and PDE4 (show PDE4A Antibodies) participate in a Gq-linked muscarinic receptor (show CHRM5 Antibodies) and adenylate cyclase 2 cAMP signalling complex.
AGS3 (show GPSM1 Antibodies) reduced D(2L)DR-mediated sensitization of AC1 (show ADCY1 Antibodies) and AC2.
A replication of association between two SNPs previously associated with COPD (show ARCN1 Antibodies) (CHRNA3 (show CHRNA3 Antibodies)/5 and IREB2 (show IREB2 Antibodies)), as well as an association with COPD (show ARCN1 Antibodies) of one locus initially associated with lung function (ADCY2).
Data suggest that SPARCL1, Shp2 (show PTPN11 Antibodies), MSH2 (show MSH2 Antibodies), E-cadherin (show CDH1 Antibodies), p53 (show TP53 Antibodies), ADCY-2 and MAPK (show MAPK1 Antibodies) are potential prognostic markers in colorectal cancer.
AC2 and AC4 (show ADCY4 Antibodies) isoforms, stimulated by GTP binding protein betagamma subunits, are expressed in bronchial nonlipid raft membrane fractions where they colocalize with and couple to prostanoid EP2 (show SPAG11B Antibodies) receptors.
AC2 interacts with RXFP1 (show RXFP1 Antibodies) through AKAP79 (show AKAP5 Antibodies), whereas the association with PDE4D3 and PKA depends upon beta-arrestin 2 (show ARRB2 Antibodies) binding to Ser704.
This study demonistrated that adcy2 knockout mice regulate the expression soluble adenylyl cyclase (show ADCY10 Antibodies) in brain.
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.
3',5'-cyclic AMP synthetase
, ATP pyrophosphate-lyase 2
, adenylate cyclase II
, adenylate cyclase type 2
, adenylate cyclase type II
, adenylyl cyclase 2
, type II adenylate cyclase